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公开(公告)号：US12064563B2
公开(公告)日：2024-08-20
申请号：US18154280
申请日：2023-01-13
CPC分类号： A61M21/00 , A61N1/36017 , A61N1/36025 , A61N1/36053 , A61N1/36092 , A61N1/36096 , A61N1/361 , A61N1/36103 , G09B23/28 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M21/02 , A61N1/36082 , A61N1/36089
摘要： A therapy method (for a patient having post-traumatic stress disorder (PTSD)) includes: providing an exposure event, to the patient, which is related to a traumatic event that contributed to the PTSD; and, during a therapy session which includes the exposure event, applying vagus nerve stimulation (VNS). A therapy method (for a patient having a given disorder, e.g., a phobia disorder or an obsessive-compulsive disorder (OCD) or an addiction disorder) includes: providing a therapy event (e.g., an extinction event for a phobia disorder), to the patient, which is related to one or more things that contributed to the given disorder; and during a therapy session which includes the therapy event, applying VNS.
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公开(公告)号：US12042356B2
公开(公告)日：2024-07-23
申请号：US17968021
申请日：2022-10-18
CPC分类号： A61F11/00 , A61B5/128 , A61N1/36053 , A61N1/361 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , G09B23/28 , H04R25/75 , A61N1/0551 , A61N1/36092 , A61N1/36132 , A61N1/37247
摘要： A method (of treating a patient who has tinnitus) includes: providing to the patient a series of tones including at least a single tone which is at least a half-octave outside a tinnitus frequency of the patient; and applying vagus nerve stimulation to the patient to induce a period of plasticity in a cortex of the patient that is transitory and that represents a transitory opportunity for learning to occur; and wherein the at least a single tone occurs during the transitory opportunity for learning.
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公开(公告)号：US09265662B2
公开(公告)日：2016-02-23
申请号：US14527194
申请日：2014-10-29
CPC分类号： A61F11/00 , A61B5/128 , A61N1/0551 , A61N1/36036 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36132 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/37247 , G06F19/00 , G09B23/28 , H04R25/75
摘要： A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
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公开(公告)号：US10213577B2
公开(公告)日：2019-02-26
申请号：US14808509
申请日：2015-07-24
摘要： Disclosed is a method of enhancing exposure therapy comprising providing an exposure therapy to a patient and stimulating the patient's vagus nerve at the same time as the exposure therapy. Also disclosed is a post-traumatic stress disorder therapy method comprising providing an exposure event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is a phobia disorder therapy method comprising providing an extinction event to a patient and stimulating the patient's vagus nerve during the exposure event. Also disclosed is an obsessive compulsive disorder therapy method comprising providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event. Also disclosed is an addiction disorder therapy method comprising providing a therapy event to a patient and stimulating the patient's vagus nerve during the therapy event.
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5.发明授权Methods, systems, and devices for pairing vagus nerve stimulation with motor therapy in stroke patients 有权用于配对迷走神经刺激与中风患者运动疗法的方法，系统和装置公开(公告)号：US09533152B2
公开(公告)日：2017-01-03
申请号：US14550357
申请日：2014-11-21
CPC分类号： A61N1/36067 , A61B5/1124 , A61N1/36003 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/37217 , A61N1/37235 , A61N1/37247 , A61N2/006 , A61N7/00 , A61N2007/0026 , G06F19/00 , G09B23/28
摘要： A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.
摘要翻译： 一种治疗卒中患者的运动障碍的方法，包括评估患者的运动缺陷，基于患者运动障碍确定患者的治疗目标，基于治疗目标选择治疗任务，重复执行所选择的治疗任务， 观察治疗任务的性能，在执行治疗任务期间大约预定的时刻手动地启动迷走神经的刺激，在执行所选择的治疗任务期间刺激患者的迷走神经，并改善患者的运动 赤字。
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公开(公告)号：US09522274B2
公开(公告)日：2016-12-20
申请号：US14550286
申请日：2014-11-21
CPC分类号： A61N1/36067 , A61B5/1124 , A61N1/36003 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/37217 , A61N1/37235 , A61N1/37247 , A61N2/006 , A61N7/00 , A61N2007/0026 , G06F19/00 , G09B23/28
摘要： A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.
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7.发明授权Methods, systems, and devices for pairing vagus nerve stimulation with motor therapy in stroke patients 有权用于配对迷走神经刺激与中风患者运动疗法的方法，系统和装置公开(公告)号：US09522272B2
公开(公告)日：2016-12-20
申请号：US14252727
申请日：2014-04-14
CPC分类号： A61N1/36067 , A61B5/1124 , A61N1/36003 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36132 , A61N1/36139 , A61N1/36178 , A61N1/37217 , A61N1/37235 , A61N1/37247 , A61N2/006 , A61N7/00 , A61N2007/0026 , G06F19/00 , G09B23/28
摘要： A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.
摘要翻译： 一种治疗卒中患者的运动障碍的方法，包括评估患者的运动缺陷，基于患者运动障碍确定患者的治疗目标，基于治疗目标选择治疗任务，重复执行所选择的治疗任务， 观察治疗任务的性能，在执行治疗任务期间大约预定的时刻手动地启动迷走神经的刺激，在执行所选择的治疗任务期间刺激患者的迷走神经，并改善患者的运动 赤字。
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公开(公告)号：US09345886B2
公开(公告)日：2016-05-24
申请号：US14497907
申请日：2014-09-26
发明人： Michael P. Kilgard , Larry Cauller , Navzer Engineer , Christa McIntyre Rodriguez , Will Rosellini
CPC分类号： A61N1/36167 , A61F11/00 , A61M21/00 , A61M21/02 , A61M2021/0016 , A61M2021/0022 , A61M2021/0027 , A61M2021/0044 , A61M2021/0072 , A61M2021/0077 , A61M2205/3515 , A61M2230/06 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/50 , A61M2230/60 , A61M2230/65 , A61N1/36014 , A61N1/36053 , A61N1/36067 , A61N1/36082 , A61N1/36092 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N5/0618 , A61N5/0622 , G09B19/00 , G09B19/003 , G09B23/28 , H04R25/75
摘要： Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.
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公开(公告)号：US09265661B2
公开(公告)日：2016-02-23
申请号：US14286177
申请日：2014-05-23
CPC分类号： A61F11/00 , A61B5/128 , A61N1/0551 , A61N1/36036 , A61N1/36053 , A61N1/36092 , A61N1/361 , A61N1/36132 , A61N1/36167 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/37247 , G06F19/00 , G09B23/28 , H04R25/75
摘要： A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
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公开(公告)号：US11471330B2
公开(公告)日：2022-10-18
申请号：US15422958
申请日：2017-02-02
摘要： A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements of the patient's hearing, selecting a plurality of therapeutic tones, where the therapeutic tones are selected to be at least a half-octave above or below of the patient's tinnitus frequency, setting an appropriate volume for each of the plurality of tones, repetitively playing each of the plurality of therapeutic tones, and pairing a vagus nerve stimulation pulse train with each playing of a therapeutic tone, thereby reducing the patient's perception of tinnitus.
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