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公开(公告)号：US20150183773A1
公开(公告)日：2015-07-02
申请号：US14643209
申请日：2015-03-10
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Mario JESKE , Dirk HEIMBACH , Susanne RÖHRIG , Yolanda CANCHO GRANDE , Dirk SCHNEIDER , Ulrich RESTER , Eckhard BENDER , Mark MEININGHAUS , Katja ZIMMERMANN , Dmitry ZUBOV , Anja BUCHMÜLLER , Georges VON DEGENFELD , Christoph GERDES , Michael GERISCH , Mark Jean GNOTH , Kersten Matthias GERICKE
IPC: C07D417/06 , A61K31/451 , C07D405/06 , A61K31/453 , A61K31/4525 , A61K31/541 , C07D401/06 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D211/60 , A61K31/4523
CPC classification number: C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
Abstract: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
Abstract translation: 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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![2-AMINO-N- [7-METHOXY-2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE-5-CARBOXAMIDES](/abs-image/US/2019/03/28/US20190092775A1/abs.jpg.150x150.jpg)
2.发明申请公开(公告)号：US20190092775A1
公开(公告)日：2019-03-28
申请号：US16082712
申请日：2017-03-01
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Thomas SCHWARZ , Ningshu LIU , Oliver POLITZ , Michael GERISCH , Dieter LANG
IPC: C07D487/04 , A61K31/5355 , A61K45/06 , A61P35/00
Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20170313665A1
公开(公告)日：2017-11-02
申请号：US15523061
申请日：2015-10-30
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KÖLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC: C07D249/12 , A61K45/06 , A61K31/4196
CPC classification number: C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
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公开(公告)号：US20160108027A1
公开(公告)日：2016-04-21
申请号：US14895625
申请日：2014-05-30
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC: C07D413/14 , C07D487/04
CPC classification number: C07D413/14 , C07D413/12 , C07D487/04
Abstract: The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
Abstract translation: 本发明涉及取代的苯并恶唑及其制备方法及其制备药物用途，用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病。
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公开(公告)号：US20170121315A1
公开(公告)日：2017-05-04
申请号：US15317519
申请日：2015-06-08
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMAN , Dirk BROHM , Hannah JÖRIßEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC: C07D405/06 , A61K31/53 , C07D409/06 , C07D413/14 , C07D409/14 , C07D413/06 , A61K45/06 , C07D405/14
CPC classification number: C07D405/06 , A61K31/53 , A61K45/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14
Abstract: The present application relates to novel heterobicyclically substituted 4-oxobutanoic acid derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
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Patent Agency Ranking
公开(公告)号：US20170119776A1
公开(公告)日：2017-05-04
申请号：US15300436
申请日：2015-03-31
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Hartmut BECK , Volkhart Min-Jian LI , Andreas TIMMERMANN , Pamela BOGNER , Yolanda CANCHO GRANDE , Dirk BROHM , Michael GERISCH , Hannah JÖRISSEN , Dieter LANG
IPC: A61K31/53 , A61K45/06 , C07D253/08
CPC classification number: A61K31/53 , A61K45/06 , C07D253/08
Abstract: The present application relates to novel, chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to a method for their preparation, to their use on their own or in combinations for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diseases of the respiratory tracts, the lung and the cardiovascular system.
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7.发明申请公开(公告)号：US20170114049A1
公开(公告)日：2017-04-27
申请号：US15300421
申请日：2015-03-31
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
CPC classification number: C07D405/12 , A61K9/0053 , A61K9/08 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2059 , A61K31/53 , A61K45/06 , A61K47/10 , A61K47/26 , C07D253/08
Abstract: The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
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公开(公告)号：US20220324865A1
公开(公告)日：2022-10-13
申请号：US17055190
申请日：2019-05-10
Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
Inventor： Steffen MUELLER , Rudolf SCHOHE-LOOP , Nuria ORTEGA HERNANDEZ , Frank SUESSMEIER , Eloisa JIMENEZ NUNEZ , Thomas BRUMBY , Niels LINDNER , Christoph GERDES , Elisabeth POOK , Anja BUCHMUELLER , Fabienne Zdenka GAUGAZ , Dieter LANG , Stefanie ZIMMERMANN , Alexander Helmut Michael EHRMANN , Michael GERISCH , Lutz LEHMANN , Andreas TIMMERMANN , Martina SCHAEFER , Georg SCHMIDT , Karl-Heinz SCHLEMMER , Markus FOLLMANN , Elisabeth KERSTEN , Vivian WANG , Xiang GAO , Yafeng WANG
IPC: C07D487/04 , A61P7/02
Abstract: The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
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9.发明申请2,5-DISUBSTITUTED CYCLOPENTANECARBOXYLIC ACIDS AND THEIR USE 审中-公开2,5-DISUBSTITUTED CYPOPENTANECARBOXYLIC ACIDS AND THEE USE公开(公告)号：US20170022171A1
公开(公告)日：2017-01-26
申请号：US15301392
申请日：2015-03-31
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC: C07D253/08 , A61K31/53 , C07D413/12 , A61K45/06
CPC classification number: C07D253/08 , A61K31/53 , A61K45/06 , C07D413/12
Abstract: The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
Abstract translation: 本申请涉及新的2,5-二取代的环戊烷羧酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/ 或预防疾病，特别是用于治疗和/或预防呼吸，肺和心血管疾病。
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公开(公告)号：US20160137647A1
公开(公告)日：2016-05-19
申请号：US14895793
申请日：2014-05-30
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC: C07D487/04 , A61K31/454 , A61K31/495 , A61K31/5386 , A61K31/4985 , A61K31/423 , C07D413/06 , A61K31/5377
CPC classification number: C07D487/04 , A61K31/423 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/5377 , A61K31/5386 , C07D263/58 , C07D413/06 , C07D417/06
Abstract: The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
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