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1.发明申请2,5-DISUBSTITUTED CYCLOPENTANECARBOXYLIC ACIDS AND THEIR USE 审中-公开2,5-DISUBSTITUTED CYPOPENTANECARBOXYLIC ACIDS AND THEE USE公开(公告)号：US20170022171A1
公开(公告)日：2017-01-26
申请号：US15301392
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC分类号： C07D253/08 , A61K31/53 , C07D413/12 , A61K45/06
CPC分类号： C07D253/08 , A61K31/53 , A61K45/06 , C07D413/12
摘要： The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
摘要翻译： 本申请涉及新的2,5-二取代的环戊烷羧酸衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/ 或预防疾病，特别是用于治疗和/或预防呼吸，肺和心血管疾病。
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公开(公告)号：US20220153745A1
公开(公告)日：2022-05-19
申请号：US17516542
申请日：2021-11-01
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , C07D409/14 , C07D409/04 , A61P35/00 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(=0)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(=0)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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公开(公告)号：US20170253602A1
公开(公告)日：2017-09-07
申请号：US15529043
申请日：2015-11-23
发明人： Andreas SCHALL , Jürgen KLAR , Mario LOBELL , Hartmut SCHIROK , Joachim TELSER , Steffen MÜLLER , Dirk BROHM , Hans BRIEM , Hannah JÖRIßEN , Joerg KELDENICH (deceased) , Michael BÖTTGER , Georges DEGENFELD VON , Thomas SCHLANGE , Ulf BÖMER , Niels LINDNER , Hanna EILKEN , Dmitrij HRISTODOROV , Pierre WASNAIRE , Kersten Matthias GERICKE , Lars BÄRFACKER
IPC分类号： C07D487/04 , A61K39/395 , A61K31/5513
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20190016724A1
公开(公告)日：2019-01-17
申请号：US15900725
申请日：2018-02-20
发明人： Dirk BROHM , Melanie HEROULT , Marie-Pierre COLLIN , Walter HÜBSCH , Mario LOBELL , Klemens LUSTIG , Sylvia GRÜNEWALD , Ulf BÖMER , Verena VÖHRINGER
IPC分类号： C07D487/04 , A61K31/541 , A61K31/5377 , A61K31/53 , A61K31/5355
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R1 is hydrogen, chloro, methyl or methoxy, R2 is hydrogen or methoxy, with the proviso that at least one of R1 and R2 is other than hydrogen, G1 represents chloro, (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group —CH2—OR3, —CH2—NR4R5 or —C(═O)-NR4R6, and G2 represents chloro, cyano, (C1-C4)-alkyl, or the group —CR8AR8B—OH, —CH2—NR9R10, —C(═O)—NR11R12 or —CH2—OR15, having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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公开(公告)号：US20170121315A1
公开(公告)日：2017-05-04
申请号：US15317519
申请日：2015-06-08
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMAN , Dirk BROHM , Hannah JÖRIßEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
IPC分类号： C07D405/06 , A61K31/53 , C07D409/06 , C07D413/14 , C07D409/14 , C07D413/06 , A61K45/06 , C07D405/14
CPC分类号： C07D405/06 , A61K31/53 , A61K45/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/14
摘要： The present application relates to novel heterobicyclically substituted 4-oxobutanoic acid derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
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公开(公告)号：US20170119776A1
公开(公告)日：2017-05-04
申请号：US15300436
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Andreas TIMMERMANN , Pamela BOGNER , Yolanda CANCHO GRANDE , Dirk BROHM , Michael GERISCH , Hannah JÖRISSEN , Dieter LANG
IPC分类号： A61K31/53 , A61K45/06 , C07D253/08
CPC分类号： A61K31/53 , A61K45/06 , C07D253/08
摘要： The present application relates to novel, chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to a method for their preparation, to their use on their own or in combinations for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diseases of the respiratory tracts, the lung and the cardiovascular system.
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7.发明申请公开(公告)号：US20170114049A1
公开(公告)日：2017-04-27
申请号：US15300421
申请日：2015-03-31
发明人： Hartmut BECK , Volkhart Min-Jian LI , Yolanda CANCHO GRANDE , Andreas TIMMERMANN , Dirk BROHM , Hannah JÖRISSEN , Pamela BOGNER , Michael GERISCH , Dieter LANG
CPC分类号： C07D405/12 , A61K9/0053 , A61K9/08 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2059 , A61K31/53 , A61K45/06 , A61K47/10 , A61K47/26 , C07D253/08
摘要： The present application relates to novel 2,5-disubstituted cyclopentanecarboxylic acid derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
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