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公开(公告)号：US20160297811A1
公开(公告)日：2016-10-13
申请号：US14896426
申请日：2014-06-03
发明人： Hartmut SCHIROK , Volker SCHULZE , Dirk KOSEMUND , Hans BRIEM , Benjamin BADER , Ulf BÖMER , Antje Margret WENGNER , Gerhard SIEMEISTER , Philip LIENAU
IPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
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公开(公告)号：US20160207928A1
公开(公告)日：2016-07-21
申请号：US14896450
申请日：2014-06-04
发明人： Volker SCHULZE , Hartmut SCHIROK , Dirk KOSEMUND , Hans BRIEM , Benjamin BADER , Ulf BÖMER , Antje Margret WENGNER , Gerhard SIEMEISTER , Philip LIENAU , Detlef STÖCKIGT , Ulrich LÜCKING , Andreas SCHALL
IPC分类号： C07D487/04 , A61K31/5025 , A61K31/4985 , A61K31/437 , A61K45/06 , C07D277/82 , C07D471/04 , A61K31/5377 , A61K31/428
CPC分类号： C07D487/04 , A61K31/428 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D277/82 , C07D471/04
摘要： The present invention relates to novel compounds showing an inhibitory effect on Mps-1 kinase, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
摘要翻译： 本发明涉及显示对Mps-1激酶的抑制作用的新化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合，用于制备药物组合物用于治疗或预防 疾病，以及可用于制备所述化合物的中间体化合物。
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公开(公告)号：US20170253602A1
公开(公告)日：2017-09-07
申请号：US15529043
申请日：2015-11-23
发明人： Andreas SCHALL , Jürgen KLAR , Mario LOBELL , Hartmut SCHIROK , Joachim TELSER , Steffen MÜLLER , Dirk BROHM , Hans BRIEM , Hannah JÖRIßEN , Joerg KELDENICH (deceased) , Michael BÖTTGER , Georges DEGENFELD VON , Thomas SCHLANGE , Ulf BÖMER , Niels LINDNER , Hanna EILKEN , Dmitrij HRISTODOROV , Pierre WASNAIRE , Kersten Matthias GERICKE , Lars BÄRFACKER
IPC分类号： C07D487/04 , A61K39/395 , A61K31/5513
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US20160272637A1
公开(公告)日：2016-09-22
申请号：US15032212
申请日：2014-10-28
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMENEZ NUNEZ , Hartmut SCHIROK , Jürgen KLAR
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20210147414A1
公开(公告)日：2021-05-20
申请号：US17046004
申请日：2019-04-03
发明人： Mario LOBELL , Hartmut SCHIROK , Adrian TERSTEEGEN
摘要： The invention relates to 5-({6-amino-2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-3-methylhexanoyl}amino)pyrazolo[1,5-a]pyridine-3-carboxamide, to processes for its preparation, to its use for the treatment and/or prophylaxis of diseases and to its use for the preparation of medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and edemas, and also ophthalmic disorders, and its use to inhibit disturbing plasma kallikrein activity for the conduct of extracorporeal procedures and analytical assays.
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6.发明申请SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开取代的碘吡啶衍生物及其在治疗心血管疾病中的应用公开(公告)号：US20160368903A1
公开(公告)日：2016-12-22
申请号：US15256608
申请日：2016-09-04
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20170283412A1
公开(公告)日：2017-10-05
申请号：US15513853
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMÉNEZ NÚNEZ , Hartmut SCHIROK , Jürgen KLAR , Mario LOBELL
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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8.发明申请Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders 有权取代的氧吡啶衍生物及其用途治疗心血管疾病公开(公告)号：US20160052884A1
公开(公告)日：2016-02-25
申请号：US14780925
申请日：2014-03-27
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRAßBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa JIMENEZ NUNEZ
IPC分类号： C07D213/64 , C07D413/12 , C07D213/84 , C07D409/06 , C07D405/06 , C07D413/14 , C07D417/12 , C07D401/12 , C07D213/69
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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