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公开(公告)号：US20220324865A1
公开(公告)日：2022-10-13
申请号：US17055190
申请日：2019-05-10
发明人： Steffen MUELLER , Rudolf SCHOHE-LOOP , Nuria ORTEGA HERNANDEZ , Frank SUESSMEIER , Eloisa JIMENEZ NUNEZ , Thomas BRUMBY , Niels LINDNER , Christoph GERDES , Elisabeth POOK , Anja BUCHMUELLER , Fabienne Zdenka GAUGAZ , Dieter LANG , Stefanie ZIMMERMANN , Alexander Helmut Michael EHRMANN , Michael GERISCH , Lutz LEHMANN , Andreas TIMMERMANN , Martina SCHAEFER , Georg SCHMIDT , Karl-Heinz SCHLEMMER , Markus FOLLMANN , Elisabeth KERSTEN , Vivian WANG , Xiang GAO , Yafeng WANG
IPC分类号： C07D487/04 , A61P7/02
摘要： The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
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![IMIDAZO[1,2-A]PYRIDINES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING CARDIOVASCULAR DISEASES](/abs-image/US/2017/02/23/US20170050962A1/abs.jpg.150x150.jpg)
2.发明申请IMIDAZO[1,2-A]PYRIDINES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR TREATING CARDIOVASCULAR DISEASES 审中-公开咪达唑[1,2-A]吡啶作为可溶性葡萄糖循环的刺激剂用于治疗心血管疾病公开(公告)号：US20170050962A1
公开(公告)日：2017-02-23
申请号：US15308230
申请日：2015-04-29
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Volkhart Min-Jian LI , Nicholas Charles RAY , Ines VUJASINOVIĆ
IPC分类号： C07D471/04 , A61K31/444 , A61K31/437 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K45/06
摘要： The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的杂环基和杂芳基取代的咪唑并[1,2-a]吡啶，其制备方法，单独或组合用于治疗和/或预防疾病的用途，以及 其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病的药物。
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![SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF](/abs-image/US/2016/06/23/US20160176880A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160176880A1
公开(公告)日：2016-06-23
申请号：US14910519
申请日：2014-08-05
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Niels LINDNER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Lisa Dietz , Volkhart Min-Jian LI
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/4985 , C07D519/00 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazinecarboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的咪唑并[1,2-a]吡嗪甲酰胺，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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![BENZYL-1H-PYRAZOLO[3,4-B]PYRIDINES AND USE THEREOF](/abs-image/US/2016/05/26/US20160145271A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160145271A1
公开(公告)日：2016-05-26
申请号：US14903347
申请日：2014-07-08
发明人： Alexandros VAKALOPOULOS , Alexey GROMOV , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Gorden REDLICH , Dieter LANG , Volkhart Min-Jian LI
IPC分类号： C07D519/00 , A61K45/06 , A61K31/53
CPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , C07D519/04
摘要： The present application relates to novel benzyl-1H-pyrazolo[3,4-b]pyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的苄基-1H-吡唑并[3,4-b]吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128386A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20140128386A1
公开(公告)日：2014-05-08
申请号：US14071274
申请日：2013-11-04
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Markus FOLLMANN , Rolf JAUTELAT , Alexander STRAUB , Jorma HAßFELD , Niels LINDNER , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva Maria BECKER-PELSTER , Andreas KNORR
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/444 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128372A1/abs.jpg.150x150.jpg)
6.发明申请公开(公告)号：US20140128372A1
公开(公告)日：2014-05-08
申请号：US13789655
申请日：2013-03-07
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Jorma HAßFELD , Niels LINDNER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva-Maria BECKER , Andreas KNORR
IPC分类号： C07D471/04 , A61K45/06 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/439 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140031391A1
公开(公告)日：2014-01-30
申请号：US13945675
申请日：2013-07-18
发明人： Michael HAHN , Markus FOLLMANN , Walter HÜBSCH , Eva-Maria BECKER , Johannes-Peter STASCH , Joerg KELDENICH , Martina DELBECK , Hanna TINEL , Frank WUNDER , Joachim MITTENDORF , Ildiko TEREBESI , Dieter LANG , René MARTIN
IPC分类号： C07D215/48 , C07D401/12 , A61K45/06 , A61K31/4706 , A61K31/4709 , C07D413/12
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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公开(公告)号：US20220023246A1
公开(公告)日：2022-01-27
申请号：US17494421
申请日：2021-10-05
IPC分类号： A61K31/216 , A61K45/06 , A61K31/41 , A61K31/506 , A61K31/519
摘要： The present invention relates to stimulators and activators of soluble guanylate cyclase in combination with an inhibitor of neutral endopeptidase and/or angiotensin AII antagonists and the use thereof for the treatment and/or prophylaxis of cardiovascular disorders, for example heart failure with preserved ejection fraction or heart failure with reduced ejection fraction, renal disorders, for example chronic kidney failure, urological disorders, lung disorders, disorders of the central nervous system, for regulation of cerebral perfusion, for example in the event of vascular cerebral states of dementia, for the treatment and/or prophylaxis of fibrotic disorders and other disease symptoms (e.g. end organ damage affecting the brain, kidney or heart).
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公开(公告)号：US20190125709A1
公开(公告)日：2019-05-02
申请号：US15746624
申请日：2016-07-15
IPC分类号： A61K31/216 , A61K31/41 , A61K45/06
摘要： The present invention relates to stimulators and activators of soluble guanylate cyclase in combination with an inhibitor of neutral endopeptidase and/or angiotensin AII antagonists and the use thereof for the treatment and/or prophylaxis of cardiovascular disorders, for example heart failure with preserved ejection fraction or heart failure with reduced ejection fraction, renal disorders, for example chronic kidney failure, urological disorders, lung disorders, disorders of the central nervous system, for regulation of cerebral perfusion, for example in the event of vascular cerebral states of dementia, for the treatment and/or prophylaxis of fibrotic disorders and other disease symptoms (e.g. end organ damage affecting the brain, kidney or heart).
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![CYANO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2017/08/03/US20170217954A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170217954A1
公开(公告)日：2017-08-03
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros VAKALOPOULOS , Philipp BUCHGRABER , Niels LINDNER , Markus FOLLMANN , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Gorden REDLICH , Lisa DIETZ , Volkhart Min-Jian LI
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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