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公开(公告)号：US20170240566A1
公开(公告)日：2017-08-24
申请号：US15503578
申请日：2015-08-25
发明人： Alexandros VAKALOPOULOS , Gaelle VALOT , Markus FOLLMANN , Damian BROCKSCHNIEDER , Johannes-Peter STASCH , Tobias MARQUARDT , Adrian TERSTEEGEN , Frank WUNDER , Lisa DIETZ , Dieter LANG , Ursula KRENZ
IPC分类号： C07D519/00 , A61K31/519 , C07D487/04 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06 , C07D487/04
摘要： The present application relates to novel amino-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20160002267A1
公开(公告)日：2016-01-07
申请号：US14771542
申请日：2014-02-25
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Dieter LANG , Alexandros VAKALOPOULOS , Frank WUNDER , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K45/06
摘要： The present application relates to novel benzyl-substituted pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的苄基取代的吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/06/26/US20140179672A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140179672A1
公开(公告)日：2014-06-26
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Jorma HAßFELD , Niels LINDNER , Alexey GROMOV , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva Maria BECKER-PELSTER , Andreas KNORR
IPC分类号： A61K31/4985 , A61K45/06 , C07D471/04 , A61K31/437 , C07D471/08 , A61K31/439
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128424A1/abs.jpg.150x150.jpg)
4.发明申请Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use 有权羟基取代的咪唑并[1,2-a] - 吡啶甲酰胺及其用途公开(公告)号：US20140128424A1
公开(公告)日：2014-05-08
申请号：US13789208
申请日：2013-03-07
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Markus FOLLMANN , Rolf JAUTELAT , Alexander STRAUB , Jorma HASSFELD , Niels LINDNER , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva-Maria BECKER , Andreas KNORR
IPC分类号： A61K31/437 , A61K45/06 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20220023246A1
公开(公告)日：2022-01-27
申请号：US17494421
申请日：2021-10-05
IPC分类号： A61K31/216 , A61K45/06 , A61K31/41 , A61K31/506 , A61K31/519
摘要： The present invention relates to stimulators and activators of soluble guanylate cyclase in combination with an inhibitor of neutral endopeptidase and/or angiotensin AII antagonists and the use thereof for the treatment and/or prophylaxis of cardiovascular disorders, for example heart failure with preserved ejection fraction or heart failure with reduced ejection fraction, renal disorders, for example chronic kidney failure, urological disorders, lung disorders, disorders of the central nervous system, for regulation of cerebral perfusion, for example in the event of vascular cerebral states of dementia, for the treatment and/or prophylaxis of fibrotic disorders and other disease symptoms (e.g. end organ damage affecting the brain, kidney or heart).
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公开(公告)号：US20190125709A1
公开(公告)日：2019-05-02
申请号：US15746624
申请日：2016-07-15
IPC分类号： A61K31/216 , A61K31/41 , A61K45/06
摘要： The present invention relates to stimulators and activators of soluble guanylate cyclase in combination with an inhibitor of neutral endopeptidase and/or angiotensin AII antagonists and the use thereof for the treatment and/or prophylaxis of cardiovascular disorders, for example heart failure with preserved ejection fraction or heart failure with reduced ejection fraction, renal disorders, for example chronic kidney failure, urological disorders, lung disorders, disorders of the central nervous system, for regulation of cerebral perfusion, for example in the event of vascular cerebral states of dementia, for the treatment and/or prophylaxis of fibrotic disorders and other disease symptoms (e.g. end organ damage affecting the brain, kidney or heart).
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![N-SUBSTITUTED 8-[(2,6-DIFLUOROBENZYL)OXY]-2,6-DIMETHYLIMIDAZO[1,2-A]PYRAZIN-3-CARBOXAMIDE DERIVATIVES AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE (SGC) FOR THE TREATMENT OF CARDIOVASCULAR DISEASES](/abs-image/US/2018/01/25/US20180022751A1/abs.jpg.150x150.jpg)
公开(公告)号：US20180022751A1
公开(公告)日：2018-01-25
申请号：US15548310
申请日：2016-02-02
发明人： Alexandros VAKALOPOULOS , Damian BROCKSCHNIEDER , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Lisa DIETZ , Min Jian Volkhart LI
IPC分类号： C07D487/04 , A61K45/06 , A61K31/695 , A61K31/4985 , C07B59/00 , C07F7/08
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07B59/002 , C07B2200/05 , C07F7/0812
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![CYANO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2017/08/03/US20170217954A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170217954A1
公开(公告)日：2017-08-03
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros VAKALOPOULOS , Philipp BUCHGRABER , Niels LINDNER , Markus FOLLMANN , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Gorden REDLICH , Lisa DIETZ , Volkhart Min-Jian LI
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20150274754A1
公开(公告)日：2015-10-01
申请号：US14738148
申请日：2015-06-12
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Nils GRIEBENOW , Dieter LANG , Frank WUNDER , Walter HÜBSCH , Alexandros VAKALOPOULOS , Adrian TERSTEEGEN
IPC分类号： C07D519/00 , A61K31/53 , A61K45/06 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20140249168A1
公开(公告)日：2014-09-04
申请号：US14194224
申请日：2014-02-28
发明人： Markus FOLLMANN , Johannes-Peter STASCH , Gorden REDLICH , Dieter LANG , Alexandros VAKALOPOULOS , Frank WUNDER , Adrian TERSTEEGEN
IPC分类号： C07D471/04 , A61K45/06 , A61K31/519
CPC分类号： C07D417/04 , A61K31/519 , A61K45/06 , C07D471/04 , C07D519/00
摘要： The present application relates to novel trifluoromethyl-substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的三氟甲基取代的稠合嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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