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公开(公告)号：US20220324865A1
公开(公告)日：2022-10-13
申请号：US17055190
申请日：2019-05-10
发明人： Steffen MUELLER , Rudolf SCHOHE-LOOP , Nuria ORTEGA HERNANDEZ , Frank SUESSMEIER , Eloisa JIMENEZ NUNEZ , Thomas BRUMBY , Niels LINDNER , Christoph GERDES , Elisabeth POOK , Anja BUCHMUELLER , Fabienne Zdenka GAUGAZ , Dieter LANG , Stefanie ZIMMERMANN , Alexander Helmut Michael EHRMANN , Michael GERISCH , Lutz LEHMANN , Andreas TIMMERMANN , Martina SCHAEFER , Georg SCHMIDT , Karl-Heinz SCHLEMMER , Markus FOLLMANN , Elisabeth KERSTEN , Vivian WANG , Xiang GAO , Yafeng WANG
IPC分类号： C07D487/04 , A61P7/02
摘要： The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.
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公开(公告)号：US20180346424A1
公开(公告)日：2018-12-06
申请号：US15513982
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Henrik TELLER
IPC分类号： C07D213/69 , C07D405/06 , C07D401/12 , A61P7/02 , A61P27/02
CPC分类号： C07D213/69 , A61K9/0048 , A61K9/0095 , A61K9/2018 , A61K9/2027 , A61K9/2059 , A61K31/00 , A61K47/36 , A61P1/04 , A61P7/02 , A61P27/02 , A61P29/00 , C07D401/12 , C07D405/06
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20170275282A1
公开(公告)日：2017-09-28
申请号：US15514276
申请日：2015-09-22
发明人： Susanne RÖHRIG , Alexander HILLISCH , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Martina SCHÄFER , Henrik TELLER , Eloisa JIMÈNEZ NÙNEZ
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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4.发明申请公开(公告)号：US20180086742A1
公开(公告)日：2018-03-29
申请号：US15786352
申请日：2017-10-17
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Harmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06 , C07D213/84 , C07D213/85 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , C07D409/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20170298052A1
公开(公告)日：2017-10-19
申请号：US15513988
申请日：2015-09-22
发明人： Susanne RÖHRIG , Eloisa JIMENEZ NUNEZ , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Henrik TELLER , Alexander HILLISCH , Stefan HEITMEIER , Martina Victoria SCHMIDT , Jan STAMPFUß
IPC分类号： C07D413/06 , C07D401/06 , C07D213/69 , C07D405/06 , C07D213/64
CPC分类号： C07D413/06 , A61P7/10 , A61P27/02 , C07D213/64 , C07D213/69 , C07D213/85 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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6.发明申请SUBSTITUTED OXOPYRIDINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF CARDIOVASCULAR DISORDERS 审中-公开取代的碘吡啶衍生物及其在治疗心血管疾病中的应用公开(公告)号：US20160368903A1
公开(公告)日：2016-12-22
申请号：US15256608
申请日：2016-09-04
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Tom KINZEL , Henrik TELLER , Hartmut SCHIROK , Jürgen KLAR , Eloisa Jimenez NUNEZ
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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公开(公告)号：US20190119213A1
公开(公告)日：2019-04-25
申请号：US15557831
申请日：2016-03-15
发明人： Susanne RÖHRIG , Henrik TELLER , Stefan HEITMEIER , Karl-Heinz SCHLEMMER , Jan STAMPFUß , Alexander HILLISCH , Adrian TERSTEEGEN , Eloisa JIMENEZ NUNEZ
IPC分类号： C07D213/69 , A61K9/20 , A61K9/00 , A61P27/02 , A61P7/02
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20180344739A1
公开(公告)日：2018-12-06
申请号：US16101250
申请日：2018-08-10
发明人： Jorma HAßFELD , Tom KINZEL , Johannes KÖBBERLING , Yolanda CANCHO-GRANDE , Kristin BEYER , Susanne RÖHRIG , Maria KÖLLNBERGER , Michael SPERZEL , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Manuel ELLERMANN
IPC分类号： A61K31/519 , C07D487/12 , A61K45/06 , C07D487/04 , C07D471/14
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US20180127401A1
公开(公告)日：2018-05-10
申请号：US15513930
申请日：2015-09-22
发明人： Susanne RÖHRIG , Eloisa JIMÉNEZ NÚNEZ , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Henrik TELLER , Alexander HILLISCH , Stefan HEITMEIER , Martina Victoria SCHMIDT , Jan STAMPFUß
IPC分类号： C07D413/14 , C07D409/14 , C07D409/12 , A61P27/02 , A61P29/00 , A61P1/00
CPC分类号： C07D413/14 , A61P1/00 , A61P27/02 , A61P29/00 , C07D409/12 , C07D409/14
摘要： The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：US20170334917A1
公开(公告)日：2017-11-23
申请号：US15523954
申请日：2015-10-30
发明人： Manuel ELLERMANN , Gaelle VALOT , Yolanda CANCHO GRANDE , Jorma HAßFELD , Tom KINZEL , Johannes KÖBBERLING , Kristin BEYER , Susanne RÖHRIG , Michael SPERZEL , Jan STAMPFUß , Imke MEYER , Maria KÖLLNBERGER , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Jörg HEIERMANN , Willem Jan HENGEVELD
IPC分类号： C07D487/04 , C07D403/14 , C07D271/10 , C07D271/06 , C07D247/02 , C07D231/00 , C07D211/06 , C07D471/04 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D211/06 , C07D231/00 , C07D247/02 , C07D271/06 , C07D271/10 , C07D403/14 , C07D471/04
摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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