公开(公告)号：US20160318866A1

公开(公告)日：2016-11-03

申请号：US15106285

申请日：2014-12-16

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Eva Maria BECKER-PELSTER ,  Philipp BUCHGRABER ,  Anja BUCHMÜLLER ,  Karen ENGEL ,  Mark Jean GNOTH ,  Herbert HIMMEL ,  Raimund KAST ,  Joerg KELDENICH ,  Jürgen KLAR ,  Andreas KNORR ,  Dieter LANG ,  Niels LINDNER ,  Carsten SCHMECK ,  Rudolf SCHOHE-LOOP ,  Hanna TINEL ,  Hubert TRÜBEL ,  Frank WUNDER

IPC: C07D211/10 ,  C07D211/42 ,  C07D211/22 ,  A61K45/06 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D211/60 ,  A61K31/4545

CPC classification number: C07D211/10 ,  A61K31/4545 ,  A61K45/06 ,  C07D211/16 ,  C07D211/22 ,  C07D211/42 ,  C07D211/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.

Abstract translation: 本发明涉及新的取代的二哌啶基衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防糖尿病性微血管病，四肢糖尿病溃疡，特别是用于促进糖尿病足溃疡的伤口愈合，糖尿病性心力衰竭，糖尿病性冠状动脉微血管性心脏病，外周和心脏血管疾病，血栓栓塞性疾病和局部缺血，外周循环障碍，雷诺 现象，CREST综合征，微循环障碍，间歇性跛行，外周和自主神经病变。

公开(公告)号：US20190284206A1

公开(公告)日：2019-09-19

申请号：US16360811

申请日：2019-03-21

Applicant: Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

Inventor： Marion HITCHCOCK ,  Anne MENGEL ,  Vera PÜTTER ,  Gerhard SIEMEISTER ,  Antje Margret WENGNER ,  Hans BRIEM ,  Knut EIS ,  Volker SCHULZE ,  Amaury Ernesto FERNANDEZ-MONTALVAN ,  Stefan PRECHTL ,  Simon HOLTON ,  Jörg FANGHÄNEL ,  Philip LIENAU ,  Cornelia PREUSSE ,  Mark Jean GNOTH

IPC: C07D498/04 ,  A61K45/06 ,  C07D413/14 ,  C07D405/14 ,  A61K31/506 ,  C07D403/04 ,  A61K31/5377 ,  A61K31/5383 ,  C07D401/14

Abstract: Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

公开(公告)号：US20170275267A1

公开(公告)日：2017-09-28

申请号：US15453679

申请日：2017-03-08

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Marion HITCHCOCK ,  Christoph-Stephan HILGER ,  Anne MENGEL ,  Hans BRIEM ,  Simon HOLTON ,  Vera PÜTTER ,  Gerhard SIEMEISTER ,  Stefan PRECHTL ,  Amaury Ernesto FERNANDEZ-MONTALVAN ,  Christian STEGMANN ,  Cornelia PREUßE ,  Mark Jean GNOTH

IPC: C07D401/14 ,  C07F7/18 ,  A61K31/5377 ,  C07D403/04 ,  A61K45/06 ,  A61K31/695 ,  A61K31/506 ,  C07D405/14

CPC classification number: C07D401/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D403/04 ,  C07D405/14 ,  C07F7/1804 ,  C07F7/188

Abstract: Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.

公开(公告)号：US20170260198A1

公开(公告)日：2017-09-14

申请号：US15438254

申请日：2017-02-21

Applicant: Bayer Intellectual Property GmbH ,  Bayer Pharma Aktiengesellschaft

Inventor： Marion HITCHCOCK ,  Anne MENGEL ,  Vera PÜTTER ,  Gerhard SIEMEISTER ,  Antje Margret WENGNER ,  Hans BRIEM ,  Knut EIS ,  Volker SCHULZE ,  Amaury Ernesto FERNANDEZ-MONTALVAN ,  Stefan PRECHTL ,  Simon HOLTON ,  Jörg FANGHÄNEL ,  Philip LIENAU ,  Cornelia PREUSSE ,  Mark Jean GNOTH

IPC: C07D498/04 ,  C07D401/14 ,  A61K31/506 ,  A61K31/5383 ,  C07D405/14 ,  A61K31/5377 ,  C07D413/14 ,  A61K45/06 ,  C07D403/04

CPC classification number: C07D498/04 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/14

Abstract: Compounds of formula (1) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

公开(公告)号：US20150183773A1

公开(公告)日：2015-07-02

申请号：US14643209

申请日：2015-03-10

Applicant: BAYER PHARMA AKTIENGESELLSCHAFT

Inventor： Mario JESKE ,  Dirk HEIMBACH ,  Susanne RÖHRIG ,  Yolanda CANCHO GRANDE ,  Dirk SCHNEIDER ,  Ulrich RESTER ,  Eckhard BENDER ,  Mark MEININGHAUS ,  Katja ZIMMERMANN ,  Dmitry ZUBOV ,  Anja BUCHMÜLLER ,  Georges VON DEGENFELD ,  Christoph GERDES ,  Michael GERISCH ,  Mark Jean GNOTH ,  Kersten Matthias GERICKE

IPC: C07D417/06 ,  A61K31/451 ,  C07D405/06 ,  A61K31/453 ,  A61K31/4525 ,  A61K31/541 ,  C07D401/06 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5377 ,  A61K31/496 ,  C07D211/60 ,  A61K31/4523

CPC classification number: C07D417/06 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/2018 ,  A61K31/451 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/10 ,  A61K47/36 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60 ,  C07D211/62 ,  C07D401/06 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.

Abstract translation: 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病