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公开(公告)号：US20210253557A1
公开(公告)日：2021-08-19
申请号：US16758741
申请日：2018-10-17
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG , Nils GRIEBENOW
Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20170320854A1
公开(公告)日：2017-11-09
申请号：US15581064
申请日：2017-04-28
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC: C07D401/14 , A61K45/06 , A61K31/4439
CPC classification number: C07D401/14 , A61K31/4439 , A61K45/06
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20160122325A1
公开(公告)日：2016-05-05
申请号：US14930157
申请日：2015-11-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KOLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC: C07D403/06 , A61K45/06 , A61K31/4196
CPC classification number: C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
Abstract translation: 本发明涉及新的5-（羟基烷基）-1-苯基-1,2,4-三唑衍生物，制备这些化合物的方法，含有这些化合物的药物组合物，以及这些化合物或组合物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管和肾脏疾病。
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公开(公告)号：US20210179590A1
公开(公告)日：2021-06-17
申请号：US16758744
申请日：2018-10-17
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Hanna TINEL , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Klemens LUSTIG
IPC: C07D403/14 , C07D403/06 , C07D405/14 , C07D401/14 , C07D413/14 , A61P9/10 , A61K45/06
Abstract: The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200017473A1
公开(公告)日：2020-01-16
申请号：US16579341
申请日：2019-09-23
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre COLLIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMUELLER , Hanna TINEL , Karoline DROEBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC: C07D401/14 , A61P9/04 , A61P13/12 , A61P3/10 , A61P9/10 , A61K45/06 , A61K31/4439
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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Patent Agency Ranking
公开(公告)号：US20170313665A1
公开(公告)日：2017-11-02
申请号：US15523061
申请日：2015-10-30
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Carsten SCHMECK , Michael GERISCH , Nils GRIEBENOW , Peter KOLKHOF , Florian KÖLLING , Anna ENGELEN , Axel KRETSCHMER , Dieter LANG , Klemens LUSTIG , Thomas MONDRITZKI , Elisabeth POOK , Hartmut BECK , Frank SÜßMEIER , Sonja VOLLMER , Pierre WASNAIRE
IPC: C07D249/12 , A61K45/06 , A61K31/4196
CPC classification number: C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
Abstract: The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
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公开(公告)号：US20170029439A1
公开(公告)日：2017-02-02
申请号：US15303212
申请日：2015-04-08
Applicant: Bayer Pharma Aktiengesellschaft
Inventor： Ulrich LÜCKING , Pierre WASNAIRE , Arne SCHOLZ , Philip LIENAU , Gerhard SIEMEISTER , Christian STEGMANN , Ulf BÖMER , Kunzeng ZHENG , Ping GAO , Gang CHEN , Jiajun XI
IPC: C07D498/14 , C07C53/18 , A61K31/4375 , C07D498/04 , A61K31/519
CPC classification number: C07D498/14 , A61K31/4375 , A61K31/519 , C07C53/18 , C07D498/04
Abstract: The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
Abstract translation: 本发明涉及本文所述和定义的通式（I）的新型大环化合物及其制备方法，其用于治疗和/或预防病症，特别是高增殖性疾病和/或病毒诱导的病症 传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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公开(公告)号：US20190161454A1
公开(公告)日：2019-05-30
申请号：US16098266
申请日：2017-05-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC: C07D249/12 , A61K45/06 , A61K31/4196 , A61P9/00 , A61P13/12
Abstract: The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190144423A1
公开(公告)日：2019-05-16
申请号：US16098308
申请日：2017-05-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC: C07D401/14 , A61P13/12 , A61P9/04 , A61P9/10 , A61P3/10
Abstract: The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190142804A1
公开(公告)日：2019-05-16
申请号：US16098255
申请日：2017-05-02
Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
Inventor： Thomas NEUBAUER , Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER
IPC: A61K31/4196 , C07D401/14 , C07D403/06 , C07D405/14 , A61K45/06 , A61K31/4439 , A61P9/10 , A61P13/12
CPC classification number: A61K31/4196 , A61K31/4439 , A61K45/06 , A61P9/10 , A61P13/12 , C07D249/12 , C07D401/14 , C07D403/06 , C07D405/14
Abstract: The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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