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    Apparatus for providing coronary retroperfusion and methods of use
    1.
    发明授权
    Apparatus for providing coronary retroperfusion and methods of use 有权
    用于提供冠状动脉灌注灌注和使用方法的装置

    公开(公告)号：US07083588B1

    公开(公告)日：2006-08-01

    申请号：US09320172

    申请日：1999-05-26

    申请人： Ascher Shmulewitz ,  John Burton ,  Robert S. Bley ,  Roy Singfatt Chin ,  Ronald C. Brown ,  Robert L. Wilcox

    发明人： Ascher Shmulewitz ,  John Burton ,  Robert S. Bley ,  Roy Singfatt Chin ,  Ronald C. Brown ,  Robert L. Wilcox

    IPC分类号： A61M5/00

    CPC分类号： A61M1/3621 ,  A61B17/0057 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1037 ,  A61M1/1081 ,  A61M1/1087 ,  A61M1/1096 ,  A61M1/12 ,  A61M1/3613 ,  A61M25/04 ,  A61M2205/32 ,  A61M2210/125

    摘要： Apparatus and methods for perfusing ischemic myocardium, and optionally, for reducing the load on a patient's left ventricle, are provided using a inlet conduit having an inlet end configured for insertion into an oxygenated blood source, including without limitation, the left atrium, left ventricle, aorta, pulmonary vein, subclavian artery, brachiocephalic artery, radial artery or femoral artery, coupled to an outlet conduit having an outlet end configured for insertion into the coronary venous vasculature via the coronary ostium. The inlet conduit may include a stylet or elastomeric sleeve that facilitates placement, while the outlet conduit may include a valve for limiting a peak pressure attained in the coronary venous system. A motor-driven or hydraulically-actuated pump optionally may be coupled in the flow path, and control circuitry provided to control the pump with a user selected duty cycle.

    摘要翻译： 用于灌注缺血心肌的装置和方法以及任选的用于减轻患者左心室负荷的装置和方法使用入口导管提供，所述入口导管具有被配置用于插入氧合血液源的入口端，包括但不限于左心房，左心室 主动脉，肺静脉，锁骨下动脉，头臂动脉，桡动脉或股动脉，联接到具有经由冠状口插入冠状静脉血管的出口端的出口导管。 入口导管可以包括便于放置的探针或弹性体套筒，而出口导管可以包括用于限制在冠状静脉系统中获得的峰值压力的阀。 可选地，电动驱动或液压致动的泵耦合在流动路径中，以及控制电路，其被提供以用用户选择的占空比来控制泵。

    Pressure-controlled continuous coronary sinus occlusion device and methods of use
    2.
    发明授权
    Pressure-controlled continuous coronary sinus occlusion device and methods of use 有权
    压力控制连续冠状动脉窦闭塞装置及使用方法

    公开(公告)号：US06569145B1

    公开(公告)日：2003-05-27

    申请号：US09275797

    申请日：1999-03-25

    申请人： Ascher Shmulewitz ,  Robert S. Bley ,  Robert L. Wilcox

    发明人： Ascher Shmulewitz ,  Robert S. Bley ,  Robert L. Wilcox

    IPC分类号： A61M3100

    CPC分类号： A61M25/0075 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12131 ,  A61B17/12136 ,  A61B17/1219 ,  A61M2025/0076 ,  A61M2025/1052 ,  A61M2210/125

    摘要： Apparatus and methods for perfusing ischemic myocardium are provided using a tubular member having an end region adapted to be disposed in a portion of a patient's venous vasculature. The end region includes a lumen and a valve in communication with the lumen that controls pressure within an occluded portion of the vasculature by venting excess blood at a location proximal of a point of occlusion of the vasculature via the valve. An occlusion element optionally may be provided in the end region that retains the tubular member within the patient's venous vasculature and occludes the flow of blow around the lumen.

    摘要翻译： 使用具有适于设置在患者静脉血管系统的一部分中的端部区域的管状构件来提供用于灌注缺血心肌的装置和方法。 端部区域包括内腔和与内腔连通的阀门，其通过经由阀在血管系统闭塞点附近的位置排出多余的血液来控制脉管系统闭塞部分内的压力。 可以在端部区域中设置闭塞元件，该端部区域将管状构件保持在患者的静脉血管内并阻塞围绕管腔的吹气流。

    PEPTIDES DERIVED FROM FICOLIN AS SURFACTANTS
    4.
    发明申请
    PEPTIDES DERIVED FROM FICOLIN AS SURFACTANTS 审中-公开
    从FICOLIN作为表面活性剂衍生的肽

    公开(公告)号：US20120058956A1

    公开(公告)日：2012-03-08

    申请号：US13254209

    申请日：2010-03-03

    申请人： Mazal Dahan ,  Ascher Shmulewitz

    发明人： Mazal Dahan ,  Ascher Shmulewitz

    IPC分类号： A61K38/10 ,  A61K38/17

    CPC分类号： C07K14/4726 ,  A61K9/0014 ,  A61K9/10 ,  A61K47/42

    摘要： Provided are peptides having a sequence that is a subsequence of a ficolin protein and methods of use thereof. The peptide may be a subsequence of human ficolin in which case it is essentially non-toxic. Further provided is a pharmaceutical composition including such peptides. The pharmaceutical composition can include an active ingredient for delivery through a body surface such as skin.

    摘要翻译： 提供具有作为ficolin蛋白的亚序列的序列的肽及其使用方法。 肽可以是人ficolin的亚序列，在这种情况下，其基本上是无毒的。 还提供了包含这些肽的药物组合物。 药物组合物可以包括用于通过身体表面如皮肤递送的活性成分。

    Stent Coating Device
    5.
    发明申请
    Stent Coating Device 失效
    支架涂装装置

    公开(公告)号：US20090288597A1

    公开(公告)日：2009-11-26

    申请号：US12534667

    申请日：2009-08-03

    申请人： Avraham Shekalim ,  Ascher Shmulewitz ,  Eyal Teichman

    发明人： Avraham Shekalim ,  Ascher Shmulewitz ,  Eyal Teichman

    IPC分类号： B05C11/00

    CPC分类号： B05C5/0216 ,  B05B12/12 ,  B05B13/0442

    摘要： The present invention is a method and device, which is suitable for use in an operating theater just prior to implantation, for selectively applying a medical coating to an implantable medical device, for example a stent. Disclosed is a device for use with a stent deployed on a catheter balloon. The device is configured to apply a medical coating of a desired thickness to the surface of a stent only. This is done by use of a drop-on-demand inkjet printing system in association with an optical scanning device. The device is further configured so as to, if necessary, apply a plurality of layered coats, each layered coat being of a different coating material, and if appropriate, different thickness. The section of the housing in which the stent is held during the coating procedure is detachable from the housing base. The detachable housing section may be easily cleaned and re-sterilized or simply disposed or simply disposed of.

    摘要翻译： 本发明是适于在植入之前适用于手术室中的方法和装置，用于选择性地将医用涂层施加到可植入医疗装置，例如支架上。 公开了一种与部署在导管气囊上的支架一起使用的装置。 该装置被配置成将仅具有所需厚度的医用涂层施加到支架的表面。 这通过使用与光学扫描装置相关联的按需喷墨打印系统来完成。 该装置进一步构造成如果需要，施加多个分层涂层，每个分层涂层是不同的涂层材料，并且如果适当，则具有不同的厚度。 支架在涂覆过程中保持的壳体的部分可从壳体基座拆卸。 可拆卸的壳体部分可以容易地清洁和重新灭菌或简单地设置或简单地处理。

    Methods and apparatus for performing sonomammography and enhanced X-ray imaging
    9.
    发明授权
    Methods and apparatus for performing sonomammography and enhanced X-ray imaging 失效
    用于进行声像学和增强X射线成像的方法和装置

    公开(公告)号：US5938613A

    公开(公告)日：1999-08-17

    申请号：US843152

    申请日：1997-04-11

    申请人： Ascher Shmulewitz

    发明人： Ascher Shmulewitz

    IPC分类号： A61B6/00 ,  A61B6/04 ,  A61B8/00 ,  A61B8/08 ,  A61B10/00 ,  A61B10/02 ,  A61B17/34 ,  A61B19/00

    CPC分类号： A61B8/4483 ,  A61B6/4291 ,  A61B6/4417 ,  A61B6/502 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/4209 ,  A61B8/4272 ,  A61B90/17 ,  A61B10/0233 ,  A61B17/3403 ,  A61B2017/00902 ,  A61B2017/00924 ,  A61B2562/168 ,  Y10S128/915

    摘要： Apparatus is provided that combines mammography equipment with an ultrasonic transducer to generate ultrasonic images of the internal structure of breast tissue that are in geometric registration with a mammogram. The apparatus includes a radiolucent and sonolucent compression plate, and in alternative embodiments, a gantry driven ultrasound transducer or a phased array ultrasonic transducer. Methods are provided for generating a mammogram and a plurality of corresponding ultrasound images without moving the breast between the mammogram exposure and the ultrasound imaging. Methods are also provided for viewing and analyzing the ultrasound images. Apparatus and methods are also provided for enhancing X-ray images obtained from conventional mammographic systems, and with reduced overall X-ray dosage to the patient.

    摘要翻译： 提供了将乳房X线照相设备与超声波换能器组合以产生与乳房X线照相几何配准的乳腺组织内部结构的超声波图像的装置。 该装置包括射线可透射和声光压缩板，并且在替代实施例中，是龙门驱动的超声波换能器或相控阵列超声换能器。 提供了用于在乳房X线照相曝光和超声成像之间移动乳房的同时产生乳房X线照片和多个对应的超声图像的方法。 还提供了用于观察和分析超声图像的方法。 还提供了用于增强从常规乳房X射线照相系统获得的X射线图像并减少对患者的总X射线剂量的装置和方法。

    Traction-inducing compression assembly for enhanced tissue imaging
    10.
    发明授权
    Traction-inducing compression assembly for enhanced tissue imaging 失效
    用于增强组织成像的牵引诱导压缩组件

    公开(公告)号：US5851180A

    公开(公告)日：1998-12-22

    申请号：US680560

    申请日：1996-07-12

    申请人： Peter Andrew Crosby ,  Ascher Shmulewitz

    发明人： Peter Andrew Crosby ,  Ascher Shmulewitz

    IPC分类号： A61B6/04 ,  A61B8/08

    CPC分类号： A61B8/0825 ,  A61B6/0414 ,  A61B6/502 ,  A61B8/483 ,  A61B6/4417 ,  A61B8/4416

    摘要： Apparatus and methods are provided for compressing biological tissue for use with a radiographic or sonographic imaging system that enhances imaging of the tissue near a patient's chest wall. The apparatus includes a compression assembly having first and second compression surfaces, and structure for positioning the first compression surface relative to the second compression surface so that the first and second compression surfaces experience a lateral translation as they move towards one another. In addition the first and second compression surfaces may be tilted slightly relative to a plane orthogonal to the patient's chest wall to enhance the traction effect and to provide partial imaging within the patient's chest wall.

    摘要翻译： 提供了用于压缩生物组织以用于增强患者胸壁附近的组织的成像的放射照相或超声成像系统的装置和方法。 该装置包括具有第一和第二压缩表面的压缩组件，以及用于相对于第二压缩表面定位第一压缩表面的结构，使得当第一和第二压缩表面朝向彼此移动时，第一和第二压缩表面经历横向平移。 此外，第一和第二压缩表面可以相对于与患者胸壁垂直的平面稍微倾斜以增强牵引效果并且在患者的胸壁内提供部分成像。