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公开(公告)号：US11944724B2
公开(公告)日：2024-04-02
申请号：US17548844
申请日：2021-12-13
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changcheng You , Jeffrey Carbeck
IPC分类号： A61L31/06 , A61B17/12 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , C08L63/00
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61M37/00 , C08L63/00 , A61B2017/12004 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61L27/18 , C08L63/00 , A61L27/18 , C08L67/04 , A61L31/06 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US11786642B2
公开(公告)日：2023-10-17
申请号：US16987754
申请日：2020-08-07
申请人： Arsenal Medical Inc.
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
IPC分类号： A61F2/02 , A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61M37/00 , C08L63/00 , A61B2017/12004 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61L27/18 , C08L63/00 , A61L27/18 , C08L67/04 , A61L31/06 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US10980920B2
公开(公告)日：2021-04-20
申请号：US15923003
申请日：2018-03-16
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changcheng You , Jeffrey Carbeck
IPC分类号： A61F2/02 , A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US20160355951A1
公开(公告)日：2016-12-08
申请号：US14603485
申请日：2015-01-23
发明人： Quynh Pham , Xuri Ray Yan , Abby Defeault , Toby Freyman , Joseph Lomakin , Gregory T. Zugates
CPC分类号： D01F8/02 , A61L15/225 , A61L15/28 , D01D5/0038 , D01F1/10 , D01F1/103 , D01F8/10 , D01F8/14 , D01F8/16 , D04H1/425 , D04H1/4382 , D04H1/728 , D04H3/005 , D10B2331/041 , D10B2331/30 , D10B2401/022 , Y10T428/2929 , Y10T442/186
摘要： According to one aspect of the invention, multicomponent fiber comprising (a) a polymeric core that comprises a core-forming polymer and (b) a polymeric sheath that comprises a hydrophilic polymer, wherein the core-forming fiber is more hydrophobic than the hydrophilic polymer and wherein the polymeric core, the polymeric sheath, or both, further comprises a hydrophilic excipient material. Other aspects of the present invention pertain to methods of forming such multicomponent fibers. Still other aspects of the present invention pertain to meshes and other articles that are formed using the multicomponent fibers.
摘要翻译： 根据本发明的一个方面，多组分纤维包含（a）包含成核聚合物的聚合物芯和（b）包含亲水性聚合物的聚合物护套，其中所述成核纤维比亲水性聚合物更疏水 并且其中所述聚合物芯，所述聚合物护套或两者还包含亲水性赋形剂材料。 本发明的其它方面涉及形成这种多组分纤维的方法。 本发明的其它方面涉及使用多组分纤维形成的网格和其它制品。
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公开(公告)号：US09044580B2
公开(公告)日：2015-06-02
申请号：US13815910
申请日：2013-03-15
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61F2/02 , A61M37/00 , A61L31/06 , A61L31/12 , A61L31/14 , A61L24/00 , A61L24/04 , A61F2/07 , A61B17/12 , A61J1/20 , A61F2/06
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US10765781B2
公开(公告)日：2020-09-08
申请号：US15642968
申请日：2017-07-06
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P Pham , Changcheng You , Jeffrey D. Carbeck
IPC分类号： A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US10307515B2
公开(公告)日：2019-06-04
申请号：US14928857
申请日：2015-10-30
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changcheng You , Jeffrey Carbeck
IPC分类号： A61F2/02 , A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US09883865B2
公开(公告)日：2018-02-06
申请号：US14728393
申请日：2015-06-02
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61F2/06 , A61B17/12 , A61M37/00 , A61L31/06 , A61L31/12 , A61L31/14 , A61L24/00 , A61L24/04 , A61F2/07 , A61J1/20
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
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公开(公告)号：US20180064855A1
公开(公告)日：2018-03-08
申请号：US15642968
申请日：2017-07-06
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changcheng You , Jeffrey D. Carbeck
IPC分类号： A61L31/06 , A61M37/00 , A61L27/58 , A61B17/12 , A61J1/20 , A61L31/14 , A61L27/56 , A61L27/18
CPC分类号： A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US09243346B2
公开(公告)日：2016-01-26
申请号：US14053994
申请日：2013-10-15
发明人： Quynh Pham , Upma Sharma , John Marini , Xuri Yan , Robert Mulligan , Toby Freyman
CPC分类号： B29C47/0014 , B29L2031/731 , D01D5/0015 , D01D5/0038 , D01D5/0069 , D01D5/34
摘要： Systems and methods for electrospinning of core-sheath fibers are provided. The systems and methods achieve optimization of a shear stress that exists at a fluid boundary between core and sheath polymer solutions, by varying certain parameters of an electrospinning apparatus and/or the solutions used therewith.
摘要翻译： 提供了芯鞘纤维静电纺丝的系统和方法。 系统和方法通过改变静电纺丝装置的某些参数和/或其使用的溶液来实现存在于芯和鞘聚合物溶液之间的流体边界处的剪切应力的优化。
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