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公开(公告)号：US10144683B2
公开(公告)日：2018-12-04
申请号：US14867179
申请日：2015-09-28
Applicant: AJINOMOTO CO., INC.
Inventor： Hiroaki Rachi , Hiromoto Watanabe , Yosuke Nishio , Keiji Takita , Satoshi Hioki
IPC: C07C7/12 , C12P5/00 , C07C7/00 , C07C7/13 , B01D53/047
Abstract: Methods include contacting a fermented gas including isoprene with a porous adsorbent and desorbing isoprene adsorbed on the porous adsorbent. The fermented gas may be obtained by culturing a microorganism having an ability to produce isoprene.
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公开(公告)号：US20180291402A1
公开(公告)日：2018-10-11
申请号：US15927573
申请日：2018-03-21
Applicant: AJINOMOTO CO., INC.
Inventor： Yasushi Hoshino , Yoshiko Inoue , Mika Moriya , Akiko Matsudaira , Yosuke Nishio
Abstract: The present invention provides a composition containing linalool, wherein the composition contains a high amount of either enantiomer R-linalool or S-linalool, and has a high content rate of linalool. The present invention also provides a production method for producing the composition. The present invention further provides a composition containing volatile components including linalool, in which a content of linalool in a total content of the volatile components in the composition is 60% or more, and the linalool is present as R-linalool or S-linalool in an amount of 50% or more of the enantiomer, and a production method therefor.
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公开(公告)号：US20170335349A1
公开(公告)日：2017-11-23
申请号：US15604772
申请日：2017-05-25
Applicant: Ajinomoto Co., Inc.
Inventor： Yoshinori TAJIMA , Hiroaki Rachi , Yosuke Nishio , Zhanna Iosifovna Katashkina , Valerievich Bylino Oleg
Abstract: Producing an isoprenoid compound by: 1) culturing an isoprenoid compound-forming microorganism in the presence of a growth promoting agent at a sufficient concentration to grow the isoprenoid compound-forming microorganism; 2) decreasing a concentration of the growth promoting agent to induce formation of the isoprenoid compound by the isoprenoid compound-forming microorganism; and 3) culturing the isoprenoid compound-forming microorganism to form the isoprenoid compound, is characterized in that the growth phase of the isoprenoid compound-forming microorganism is separated from the formation phase of the isoprenoid compound.
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公开(公告)号：US10941420B2
公开(公告)日：2021-03-09
申请号：US15927573
申请日：2018-03-21
Applicant: AJINOMOTO CO., INC.
Inventor： Yasushi Hoshino , Yoshiko Inoue , Mika Moriya , Akiko Matsudaira , Yosuke Nishio
Abstract: The present invention provides a composition containing linalool, wherein the composition contains a high amount of either enantiomer R-linalool or S-linalool, and has a high content rate of linalool. The present invention also provides a production method for producing the composition. The present invention further provides a composition containing volatile components including linalool, in which a content of linalool in a total content of the volatile components in the composition is 60% or more, and the linalool is present as R-linalool or S-linalool in an amount of 50% or more of the enantiomer, and a production method therefor.
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公开(公告)号：US10144684B2
公开(公告)日：2018-12-04
申请号：US14867191
申请日：2015-09-28
Applicant: AJINOMOTO CO., INC.
Inventor： Hiroaki Rachi , Hiromoto Watanabe , Yosuke Nishio , Keiji Takita , Satoshi Hioki
IPC: C07C7/12 , C12P5/00 , C07C7/00 , C07C7/13 , B01D53/047
Abstract: Methods include contacting a fermented gas including isoprenoid compound with a porous adsorbent and desorbing isoprenoid compound adsorbed on the porous adsorbent. The fermented gas may be obtained by culturing a microorganism having an ability to produce isoprenoid compound.
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Patent Agency Ranking
6.发明授权Isoprene synthase and gene encoding the same, and method for producing isoprene monomer 有权异戊二烯合酶和编码基因的基因，以及生产异戊二烯单体的方法公开(公告)号：US08962296B2
公开(公告)日：2015-02-24
申请号：US13832260
申请日：2013-03-15
Applicant: Bridgestone Corporation , Ajinomoto Co., Inc.
Inventor： Yasuyuki Hayashi , Minako Harada , Saaya Takaoka , Yasuo Fukushima , Keiichi Yokoyama , Yosuke Nishio , Yoshinori Tajima , Yoko Mihara , Kunio Nakata
IPC: C12N9/88 , C12P21/06 , C12P19/34 , C12N15/00 , C12N1/20 , C12N1/00 , C12P5/02 , C07H21/04 , C07K1/00 , C12P5/00
CPC classification number: C12P5/007 , C12N9/88 , C12P5/00 , C12Y402/03027
Abstract: The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a), (b), or (c): (a) a polynucleotide comprising (i) the nucleotide sequence represented by SEQ ID NO:1, or (ii) the nucleotide sequence consisting of the nucleotide residues at positions 133 to 1785 in the nucleotide sequence represented by SEQ ID NO:1; (b) a polynucleotide that comprises a nucleotide sequence having 90% or more identity to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; or (c) a polynucleotide that hybridizes under a stringent condition with a polynucleotide consisting of a nucleotide sequence complementary to the nucleotide sequence of (i) or (ii) above, and encodes a protein having an isoprene synthase activity; and the like.
Abstract translation: 本发明提供了用于建立优异的异戊二烯单体生产系统的方法。 具体而言，本发明提供下述（a），（b）或（c）所示的多核苷酸：（a）包含（i）由SEQ ID NO：1表示的核苷酸序列的多核苷酸，或（ii） 由SEQ ID NO：1所示的核苷酸序列的133〜1785位核苷酸残基组成的序列; （b）包含与上述（i）或（ii）的核苷酸序列具有90％以上同一性的核苷酸序列的多核苷酸，并编码具有异戊二烯合酶活性的蛋白质; 或（c）在严格条件下与由上述（i）或（ii）的核苷酸序列互补的核苷酸序列组成的多核苷酸杂交的多核苷酸，并编码具有异戊二烯合酶活性的蛋白质; 等等。
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公开(公告)号：US10184137B2
公开(公告)日：2019-01-22
申请号：US14670614
申请日：2015-03-27
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko Mihara , Hiroaki Rachi , Yosuke Nishio , Yosifovna Joanna Katashkina , Dmitrievna Ekaterina Kazieva , Georgievna Irina Andreeva
Abstract: A host cell includes a heterogeneous expression unit including: (a) a polynucleotide encoding a mevalonate kinase derived from a microorganism belonging to a genus selected from Methanocella, Corynebacterium, Methanosaeta, and Nitrosopumilus, and (b) a promoter operatively linked to the polynucleotide. The host cell is used to produce mevalonate kinase, mevalonate-5-phosphate, and isoprenoid compounds.
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公开(公告)号：US20180291403A1
公开(公告)日：2018-10-11
申请号：US15927622
申请日：2018-03-21
Applicant: AJINOMOTO CO., INC.
Inventor： Yasushi Hoshino , Akiko Matsudaira , Mika Moriya , Nobuhisa Nitta , Yosuke Nishio
Abstract: The present invention describes an efficient method for producing linalool. The present invention provides a method for producing linalool, the method including culturing a microorganism expressing linalool synthase in a culture medium to produce linalool. The present invention also describes a microorganism able to express linalool synthase and efficiently produce linalool.
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公开(公告)号：US20150275233A1
公开(公告)日：2015-10-01
申请号：US14670614
申请日：2015-03-27
Applicant: AJINOMOTO CO., INC.
Inventor： Yoko MIHARA , Hiroaki Rachi , Yosuke Nishio , Yosifovna Joanna Katashkina , Dmitrievna Ekaterina Kazieva , Georgievna Irina Andreeva
IPC: C12P5/00 , C12P9/00 , C08F136/08 , C12N9/12
CPC classification number: C12P5/007 , B60C1/00 , C08F136/08 , C12N9/1205 , C12P9/00 , C12Y207/01036 , C08K5/0025 , C08L9/00
Abstract: A host cell includes a heterogeneous expression unit including: (a) a polynucleotide encoding a mevalonate kinase derived from a microorganism belonging to a genus selected from Methanocella, Corynebacterium, Methanosaeta, and Nitrosopumilus, and (b) a promoter operatively linked to the polynucleotide. The host cell is used to produce mevalonate kinase, mevalonate-5-phosphate, and isoprenoid compounds.
Abstract translation: 宿主细胞包括异源表达单位，其包括：（a）编码源自属于属于选自Methanocella，Corynebacterium，Methanosaeta和Nitrosopomilus的属的微生物的甲羟戊酸激酶的多核苷酸，和（b）与多核苷酸可操作连接的启动子。 宿主细胞用于产生甲羟戊酸激酶，甲羟戊酸-5-磷酸和类异戊二烯化合物。
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公开(公告)号：US20130316401A1
公开(公告)日：2013-11-28
申请号：US13939291
申请日：2013-07-11
Applicant: AJINOMOTO CO., INC.
Inventor： Yosuke Nishio , Eiichiro Kimura , Yoshihiro Usuda , Kazuho Ikeo , Yoji Nakamura , Takashi Gojobori , Yutaka Kawarabayashi , Yumi Hino , Eiichi Hori , Jun Yamazaki
CPC classification number: C12N9/88 , C12N9/00 , C12N9/0016 , C12N9/1205 , C12N15/1034 , C12N15/1089
Abstract: A method for improving the thermostability of a protein includes introducing, into the protein, two or more amino acid substitutions selected from the group consisting of: (i) substitution of an arginine residue for a lysine residue, (ii) substitution of a threonine residue for a serine residue, and (iii) substitution of an alanine residue for a serine residue.
Abstract translation: 提高蛋白质热稳定性的方法包括向蛋白质中引入选自以下的两个或多个氨基酸取代：（i）精氨酸残基取代赖氨酸残基，（ii）苏氨酸残基的取代 用于丝氨酸残基，和（iii）用丙氨酸残基取代丝氨酸残基。
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