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1.发明授权公开(公告)号：US08895056B2
公开(公告)日：2014-11-25
申请号：US13725525
申请日：2012-12-21
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil, Jr. , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F. A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC classification number: A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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公开(公告)号：US20150086603A1
公开(公告)日：2015-03-26
申请号：US14557299
申请日：2014-12-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed F.A. Hossainy , Dariush Davalian , Jinping Wan , Hong Ma
CPC classification number: A61L31/06 , A61K9/0024 , A61K9/127 , A61K9/5153 , A61K9/5192 , A61L31/00
Abstract: The present invention relates to implantable medical devices containing surface-treated, dual-targeted drug carriers for treating vascular diseases.
Abstract translation: 本发明涉及包含用于治疗血管疾病的表面处理的双靶向药物载体的可植入医疗装置。
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Patent Agency Ranking
3.发明申请REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开用于治疗血管疾病的治疗药物的区域性递送公开(公告)号：US20150045877A1
公开(公告)日：2015-02-12
申请号：US14521126
申请日：2014-10-22
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil, JR. , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irinia Astafieva , Jinping Wan , Fozan EI-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC classification number: A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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4.发明申请MULTIPLE GROWTH FACTOR COMPOSITIONS, METHODS OF FABRICATION, AND METHODS OF TREATMENT 审中-公开多重生长因子组合物，制备方法和处理方法公开(公告)号：US20140199377A1
公开(公告)日：2014-07-17
申请号：US14218279
申请日：2014-03-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
CPC classification number: A61K38/30 , A61K9/06 , A61K9/127 , A61K35/34 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/193 , A61K38/57 , A61K45/06 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2300/626 , A61L2430/20 , A61K2300/00
Abstract: Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
Abstract translation: 公开了具有与至少两种不同类型的生长因子相关联的持续释放载体的组合物及其制备和处理方法。 在一些实施方案中，生长因子的同时释放可以是优选的，而在其它实施方案中，生长因子的顺序释放可能是优选的。 至少两个生长因子施加到损伤部位，例如由心肌梗塞或缺血性心力衰竭引起的受损的心脏组织可以更好地模拟和诱导改善心脏功能所必需的复合生长因子信号传导途径。 当在心肌梗死或缺血性心力衰竭后应用于患者时，持续释放载体平台或平台内的多个生长因子可能对旨在减轻左心室重塑的注射细胞产生协同效应。 治疗方法包括使用导管和/或注射器的经皮，亚剑虫和胸部开胸方法。
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公开(公告)号：US08697058B2
公开(公告)日：2014-04-15
申请号：US13623863
申请日：2012-09-20
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Shubhayu Basu , Gene Michal , Florian N. Ludwig , Jinping Wan , John Stankus
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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6.发明申请NANOPARTICLE LOADED ELECTROSPUN IMPLANTS OR COATINGS FOR DRUG RELEASE 审中-公开NANOPARTICLE LOADED ELECTROSPUN IMPLANTS或涂料用于药物释放公开(公告)号：US20140358217A1
公开(公告)日：2014-12-04
申请号：US14462476
申请日：2014-08-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John Stankus , Syed F.A. Hossainy , Jinping Wan
IPC: A61F2/86
CPC classification number: A61F2/86 , A61L31/14 , B32B1/08 , D01D5/0069 , D01F1/10 , D04H1/728 , D04H1/76
Abstract: Medical devices, such as stents, including a fibrous layer including particles are disclosed. Methods of forming such medical devices using electrospinning are disclosed.
Abstract translation: 公开了包括包括颗粒的纤维层在内的医疗装置，例如支架。 公开了使用静电纺丝形成这种医疗装置的方法。
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7.发明申请公开(公告)号：US20130129814A1
公开(公告)日：2013-05-23
申请号：US13725525
申请日：2012-12-21
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil, JR. , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irina Astafieva , Jinping Wan , Fozan El-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
IPC: A61M25/10
CPC classification number: A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
Abstract translation: 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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