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公开(公告)号：US20180154051A1
公开(公告)日：2018-06-07
申请号：US15797218
申请日：2017-10-30
发明人： Syed F.A. Hossainy , Fuh-Wei Tang , Lothar W. Kleiner , Thierry Glauser , Yiwen Tang , Wouter E. Roorda , Stephen D. Pacetti , Gina Zhang , Yung-Ming Chen , Andrew F. McNiven , Sean A. McNiven , Brandon J. Yoe
IPC分类号： A61L31/10 , A61L27/54 , A61L31/16 , A61L27/40 , A61L27/44 , A61L27/50 , A61L31/12 , A61L31/14
CPC分类号： A61L31/10 , A61L27/40 , A61L27/44 , A61L27/50 , A61L27/54 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/00
摘要： The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
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公开(公告)号：US20160303295A1
公开(公告)日：2016-10-20
申请号：US15192973
申请日：2016-06-24
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
摘要翻译： 本发明提供了一种用于可植入装置的可吸收涂层及其制造和使用方法。
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公开(公告)号：US20150086603A1
公开(公告)日：2015-03-26
申请号：US14557299
申请日：2014-12-01
发明人： Syed F.A. Hossainy , Dariush Davalian , Jinping Wan , Hong Ma
CPC分类号： A61L31/06 , A61K9/0024 , A61K9/127 , A61K9/5153 , A61K9/5192 , A61L31/00
摘要： The present invention relates to implantable medical devices containing surface-treated, dual-targeted drug carriers for treating vascular diseases.
摘要翻译： 本发明涉及包含用于治疗血管疾病的表面处理的双靶向药物载体的可植入医疗装置。
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4.发明申请REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开用于治疗血管疾病的治疗药物的区域性递送公开(公告)号：US20150045877A1
公开(公告)日：2015-02-12
申请号：US14521126
申请日：2014-10-22
发明人： Stephen D. Pacetti , Paul M. Consigny , Ronald W. Heil, JR. , Florian Niklas Ludwig , Dariush Davalian , Li Zhao , Irinia Astafieva , Jinping Wan , Fozan EI-Nounou , Katsuyuki Murase , Syed F.A. Hossainy , Rachel Bright , Jeffrey Ellis
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译： 本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织 受影响组织的外围也是如此。
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公开(公告)号：US20140186417A1
公开(公告)日：2014-07-03
申请号：US14185699
申请日：2014-02-20
CPC分类号： A61L31/10 , A61L27/34 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2400/18 , A61L2420/08 , C08L67/04
摘要： An aliphatic polyester polymer for stent coating is described.
摘要翻译： 描述了用于支架涂层的脂族聚酯聚合物。
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6.发明申请公开(公告)号：US20170112646A1
公开(公告)日：2017-04-27
申请号：US15399632
申请日：2017-01-05
CPC分类号： A61F2/915 , A61F2/06 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/825 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2230/0054 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/412 , C08L67/04
摘要： Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters.
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7.发明申请公开(公告)号：US20150351942A1
公开(公告)日：2015-12-10
申请号：US14712647
申请日：2015-05-14
IPC分类号： A61F2/86
CPC分类号： A61F2/86 , A61F2210/0076 , A61F2230/0069 , A61L31/10 , A61L31/129
摘要： Stents fabricated from polymer composites toughened by a dispersed phase are disclosed.
摘要翻译： 公开了由分散相增韧的聚合物复合材料制成的支架。
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公开(公告)号：US20150182672A1
公开(公告)日：2015-07-02
申请号：US14643576
申请日：2015-03-10
发明人： Eugene T. Michal , Syed F.A. Hossainy , Ashok Shah
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
摘要翻译： 本申请教导了具有与聚合物缀合或混合的生物相容性化合物的涂层，其中所述聚合物包括至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇或其衍生物的单元 。
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公开(公告)号：US20150073536A1
公开(公告)日：2015-03-12
申请号：US14121435
申请日：2014-09-04
CPC分类号： A61F2/86 , A61F2/915 , A61F2002/91558 , A61F2002/91566 , A61F2210/0004 , A61F2250/0067 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
摘要： A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment.
摘要翻译： 公开了一种治疗患者血管疾病的方法，其包括在患者的动脉的狭窄部分部署由多个支柱构成的生物可吸收聚合物支架，其中在所述支架之后以增加的直径支撑所述片段一段时间 聚合物降解的时间逐渐被包含蛋白多糖的可延展的临时基质的从头形成所替代，其中当支架变得更有韧性并且随着其降解而变得断裂，其中由新内膜层覆盖支柱并且由 通过骨架段的血管壁的正重构，支架被向外拉。
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公开(公告)号：US20140127278A1
公开(公告)日：2014-05-08
申请号：US13668019
申请日：2012-11-02
发明人： Syed F.A. Hossainy
IPC分类号： A61K9/00 , A61P29/00 , A61P9/00 , A61K31/56 , A61K31/573 , A61K31/436 , A61K38/06
CPC分类号： A61K9/00 , A61K31/56 , A61K31/573 , A61L31/16 , A61L2300/25 , A61L2300/41 , A61L2300/416 , A61L2420/08
摘要： The present invention relates to the treatment of vascular disease in a diabetic patient using a drug-eluting implantable medical device that releases everolimus from three distinctly loaded drug reservoir layers wherein at least one of the layers comprises at least 200 μg/cm2 of everolimus and further wherein the everolimus is the only therapeutic agent in the layers or the layers or any combination thereof further comprise an anti-inflammatory agent or an RGD peptide or both.
摘要翻译： 本发明涉及使用药物洗脱可植入医疗装置治疗糖尿病患者的血管疾病，所述药物洗脱可植入医疗装置从三个明显负载的药物储存层释放依维莫司，其中至少一个层包含至少200μg/ cm 2的依维莫司 其中依维莫司是层或层中唯一的治疗剂或其任何组合进一步包含抗炎剂或RGD肽或两者。
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