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公开(公告)号：US09687630B2
公开(公告)日：2017-06-27
申请号：US13898412
申请日：2013-05-20
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： Shubhayu Basu , Gregory Waimong Chan
CPC classification number: A61M25/003 , A61M25/00 , A61M25/0032 , A61M25/0084 , A61M25/10
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
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公开(公告)号：US09539410B2
公开(公告)日：2017-01-10
申请号：US13898413
申请日：2013-05-20
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： Shubhayu Basu , Gregory Waimong Chan , Sungwoo Min
CPC classification number: A61M25/003 , A61K9/0019 , A61K9/06 , A61M25/0084 , A61M25/10 , A61M2025/0085 , A61M2025/0087
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。
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公开(公告)号：US20150209473A1
公开(公告)日：2015-07-30
申请号：US14685474
申请日：2015-04-13
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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公开(公告)号：US09402814B2
公开(公告)日：2016-08-02
申请号：US14299764
申请日：2014-06-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Shubhayu Basu , Eugene T. Michal
CPC classification number: A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodible material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与生物可腐蚀材料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。
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5.发明申请MODIFIED TWO-COMPONENT GELATION SYSTEMS, METHODS OF USE AND METHODS OF MANUFACTURE 审中-公开改性双组分凝胶系统，使用方法和制造方法公开(公告)号：US20140348800A1
公开(公告)日：2014-11-27
申请号：US14290752
申请日：2014-05-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Gene Michal , Shubhayu Basu
CPC classification number: A61K35/28 , A61K33/14 , A61K33/20 , A61K38/1858 , A61K38/363 , A61K38/4833 , A61L27/26 , A61L27/3873 , A61L27/52 , C12Y304/21005 , A61K2300/00 , A61K38/00
Abstract: A bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture. A treatment agent, such as a cell type or a growth factor, can be added to either the first mixture or the second mixture. In some embodiments, the treatment agent is not added to either mixture. The first mixture can be co-injected with the second mixture to form a bioscaffolding in an infarct region for treatment thereof.
Abstract translation: 生物支架可以由不同凝胶化系统的凝胶组分的混合物形成。 例如，生物支架可以通过混合至少两种不同的双组分凝胶化体系的至少两种不同组分形成第一混合物并通过混合至少两种不同组分（构成第一混合物的组分） 的至少两种不同的双组分凝胶化体系以形成第二混合物。 可以将第一混合物或第二混合物中的处理剂如细胞类型或生长因子加入。 在一些实施方案中，处理剂不加入任何混合物中。 可以将第一混合物与第二混合物共注射以在梗塞区域中形成生物支架，用于治疗它们。
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Patent Agency Ranking
公开(公告)号：US20140294945A1
公开(公告)日：2014-10-02
申请号：US14299764
申请日：2014-06-09
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Shubhayu Basu , Eugene T. Michal
CPC classification number: A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
Abstract: A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
Abstract translation: 描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。 从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。 颗粒可以沉积在包含液相的收集组件中。 另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合 描述了形成凝胶的能力。 具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。
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公开(公告)号：US20130338633A1
公开(公告)日：2013-12-19
申请号：US13898412
申请日：2013-05-20
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： Shubhayu Basu , Gregory Waimong Chan
IPC: A61M25/00
CPC classification number: A61M25/003 , A61M25/00 , A61M25/0032 , A61M25/0084 , A61M25/10
Abstract: Methods and compositions for treating post-myocardial infarction damage are herein disclosed. In some embodiments, a carrier with a treatment agent may be fabricated. The carrier can be formulated from a bioerodable, sustained-release substance. The resultant loaded carrier may then be suspended in at least one component of a two-component matrix system for simultaneous delivery to a post-myocardial infarction treatment area.
Abstract translation: 本文公开了治疗心肌梗死后损伤的方法和组合物。 在一些实施方案中，可以制造具有处理剂的载体。 载体可以由生物可蚀塑的缓释物质配制。 然后将所得负载载体悬浮在双组分基质系统的至少一个组分中，用于同时递送至心肌梗死后治疗区域。
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公开(公告)号：US09775930B2
公开(公告)日：2017-10-03
申请号：US14685474
申请日：2015-04-13
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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公开(公告)号：US20170258961A9
公开(公告)日：2017-09-14
申请号：US14685474
申请日：2015-04-13
Inventor： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
CPC classification number: A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
Abstract: A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.
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10.发明申请MULTIPLE GROWTH FACTOR COMPOSITIONS, METHODS OF FABRICATION, AND METHODS OF TREATMENT 审中-公开多重生长因子组合物，制备方法和处理方法公开(公告)号：US20140199377A1
公开(公告)日：2014-07-17
申请号：US14218279
申请日：2014-03-18
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： John J. Stankus , Florian N. Ludwig , Evgenia Mandrusov , Liangxuan Zhang , Hong Ma , Jinping Wan , Shubhayu Basu
CPC classification number: A61K38/30 , A61K9/06 , A61K9/127 , A61K35/34 , A61K38/18 , A61K38/1825 , A61K38/1833 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/193 , A61K38/57 , A61K45/06 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/604 , A61L2300/626 , A61L2430/20 , A61K2300/00
Abstract: Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.
Abstract translation: 公开了具有与至少两种不同类型的生长因子相关联的持续释放载体的组合物及其制备和处理方法。 在一些实施方案中，生长因子的同时释放可以是优选的，而在其它实施方案中，生长因子的顺序释放可能是优选的。 至少两个生长因子施加到损伤部位，例如由心肌梗塞或缺血性心力衰竭引起的受损的心脏组织可以更好地模拟和诱导改善心脏功能所必需的复合生长因子信号传导途径。 当在心肌梗死或缺血性心力衰竭后应用于患者时，持续释放载体平台或平台内的多个生长因子可能对旨在减轻左心室重塑的注射细胞产生协同效应。 治疗方法包括使用导管和/或注射器的经皮，亚剑虫和胸部开胸方法。
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