专利检索 ap:"Yoshiharu Mizui" 第 1 页

1.

发明申请
METHOD FOR ASSAYING ACTION OF ANTITUMOR AGENT USING DECREASE IN GENE EXPRESSION LEVEL AS INDEX 审中-公开
标题翻译：使用降解在基因表达水平作为指标的抗肿瘤剂的作用方法

公开(公告)号：US20100086931A1

公开(公告)日：2010-04-08

申请号：US12529971

申请日：2008-03-05

申请人： Yoshiharu Mizui , Naoko Hata , Masao Iwata , Rie Sugano , Naoki Toritsuka , Taku Yoshida , Mai Uesugi , Tadashi Kadowaki

发明人： Yoshiharu Mizui , Naoko Hata , Masao Iwata , Rie Sugano , Naoki Toritsuka , Taku Yoshida , Mai Uesugi , Tadashi Kadowaki

IPC分类号： C12Q1/68 , C07D407/06 , C07H21/04 , C07K16/00

CPC分类号： G01N33/5011

摘要： An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the pladienolide derivative using a decrease in gene expression level as an index.

摘要翻译： 本发明的目的是提供一种方法，探针，引物，抗体，试剂和用于测定普遍二烯内酰脲衍生物对活体的作用的试剂盒。根据本发明，提供了使用基因表达水平降低作为指标来测定普拉二烯内酯衍生物的作用的方法。

2.

发明授权
Bioactive substance 有权
标题翻译：生物活性物质

公开(公告)号：US07667052B2

公开(公告)日：2010-02-23

申请号：US11213962

申请日：2005-08-30

申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori

发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori

IPC分类号： C07D313/00 , C07D407/06 , A61K31/365

CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02

摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.

摘要翻译： 本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

3.

发明授权
Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物

公开(公告)号：US07799827B2

公开(公告)日：2010-09-21

申请号：US10507067

申请日：2003-03-07

申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/335 , C07D313/00

CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411

摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.

摘要翻译： 本发明提供了具有式（I）的化合物：另外提供了其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病以及涉及恶性肿瘤或增加血管发生的疾病）的方法，其中R1-R11， X，Y，Z和n如本文所定义。

4.

发明申请
Novel bioactive substance 有权
标题翻译：新型生物活性物质

公开(公告)号：US20060079572A1

公开(公告)日：2006-04-13

申请号：US11213962

申请日：2005-08-30

申请人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori

发明人： Yoshiharu Mizui , Takashi Sakai , Satoshi Yamamoto , Keisuke Komeda , Masanori Fujita , Akifumi Okuda , Kumiko Kishi , Jun Niijima , Mitsuo Nagai , Kiyoshi Okamoto , Masao Iwata , Yoshihiko Kotake , Toshimitsu Uenaka , Naoki Asai , Motoko Matsufuji , Tomohiro Sameshima , Naoto Kawamura , Kazuyuki Dobashi , Takashi Nakashima , Masashi Yoshida , Toshio Tsuchida , Susumu Takeda , Tomonari Yamada , Koji Norihisa , Takao Yamori

IPC分类号： A61K31/365 , C07D313/00

CPC分类号： C07D405/14 , A61K31/335 , A61K31/336 , A61K31/4025 , A61K31/4427 , A61K31/4523 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K31/74 , C07D313/00 , C07D407/06 , C07D407/14 , C07D493/04 , C07D493/08 , C12P17/02

摘要： The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.

摘要翻译： 本发明提供了具有抗肿瘤活性的新型生物活性物质及其制造方法及其医疗用途。即，它提供了由下列公式表示的12元环大环内酯化合物，其由Streptomyces sp。梅尔 11107或其变体，其药理学上可接受的盐或它们的水合物及其制备方法。

5.

发明授权
Macrocyclic compounds useful as pharmaceuticals 有权
标题翻译：用作药物的大环化合物

公开(公告)号：US07915306B2

公开(公告)日：2011-03-29

申请号：US10657910

申请日：2003-09-09

申请人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda

发明人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda

IPC分类号： A61K31/335

CPC分类号： C07D493/04 , C07D313/00

摘要： The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).

摘要翻译： 本发明提供了包含具有式（I）的化合物的组合物：另外提供了其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，X，Y， Z和n如本文所定义。在某些实施方案中，组合物用于全身（例如口服）给药。在某些实施方案中，用于治疗各种疾病（包括炎性或自身免疫性疾病）的方法包括全身（例如，口服）向有需要的受试者施用治疗有效量的式（I）化合物。

6.

发明申请
METHOD FOR ASSAYING ACTION OF ANTITUMOR AGENT USING SPLICING DEFECTS AS INDEX 审中-公开
标题翻译：使用分离缺陷作为指标测定抗菌剂的作用方法

公开(公告)号：US20100021918A1

公开(公告)日：2010-01-28

申请号：US12529959

申请日：2008-03-05

申请人： Yoshiharu Mizui , Naoko Hata , Masao Iwata , Koji Sagane , Mai Uesugi , Tadashi Kadowaki , Taku Yoshida

发明人： Yoshiharu Mizui , Naoko Hata , Masao Iwata , Koji Sagane , Mai Uesugi , Tadashi Kadowaki , Taku Yoshida

IPC分类号： C12Q1/68 , C07H21/04 , G01N33/53 , C07K16/00

CPC分类号： G01N33/5011 , C12Q1/6883 , G01N33/68

摘要： An object of the present invention is to provide a method, a probe, a primer, an antibody, a reagent, and a kit for assaying an action of a pladienolide derivative to a living subject. According to the present invention, there is provided a method for assaying an action of the pladienolide derivative using splicing defect as an index.

摘要翻译： 本发明的目的是提供一种方法，探针，引物，抗体，试剂和用于测定普遍二烯内酰脲衍生物对活体的作用的试剂盒。根据本发明，提供了使用拼接缺陷作为指标来测定扁桃苷内酰胺衍生物的作用的方法。

7.

发明申请
TARGET MOLECULES OF PLADIENOLIDES, COMPOUNDS BINDING TO SUCH TARGET MOLECULES, AND SCREENING METHOD THEREOF 审中-公开
标题翻译：对这些目标分子的化合物，化合物的目标分子和筛选方法

公开(公告)号：US20090227795A1

公开(公告)日：2009-09-10

申请号：US12375516

申请日：2007-08-02

申请人： Yoshihiko Kotake , Koji Sagane , Takashi Owa , Yoshiharu Mizui , Hajime Shimizu , Yuko Kiyosue

发明人： Yoshihiko Kotake , Koji Sagane , Takashi Owa , Yoshiharu Mizui , Hajime Shimizu , Yuko Kiyosue

IPC分类号： C07D405/14 , G01N33/566 , C07D409/14 , C07F5/02 , C07D407/06 , A61P35/00

CPC分类号： A61K31/365 , A61K31/496 , C07D407/04 , C07D495/04 , G01N33/6875 , G01N2500/04

摘要： A method of measuring the binding activity of a test compound to a splicing factor 3b (SF3b), which comprises the following steps of: (a) contacting a labeled pladienolide compound and a test compound with a cell or a cell fraction; and (b) measuring the distribution of the bound labeled compound. The method enables to screen for a novel active compound capable of acting on (binding to) a pladienolide target molecule or the like.

摘要翻译： 测试化合物与剪接因子3b（SF3b）的结合活性的方法，其包括以下步骤：（a）使标记的普拉二烯内酯化合物和测试化合物与细胞或细胞级分接触; 和（b）测量结合的标记化合物的分布。该方法能够筛选能够作用于（结合）扁桃苷内酯靶分子等的新型活性化合物。