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公开(公告)号：US20120184263A1
公开(公告)日：2012-07-19
申请号：US13433705
申请日：2012-03-29
申请人： Takatoshi KAWAI , Kaoru ISHIDA
发明人： Takatoshi KAWAI , Kaoru ISHIDA
CPC分类号： H04B1/0475 , H03F1/34 , H03F3/24 , H04B2001/0433
摘要： A radio transmission apparatus according to the present invention detects an output current of a power supply section that varies in response to a variation of the output impedance of an amplification section, and corrects a distortion of the input/output characteristic of the amplification section by using an LUT corresponding to the detected output current. In addition, a threshold used for switching an LUT is caused to be different depending on a switching direction between LUTs, thereby suppressing frequent occurrence of switching of the LUT.
摘要翻译： 根据本发明的无线电发送装置检测响应于放大部分的输出阻抗的变化而变化的电源部分的输出电流，并且通过使用来校正放大部分的输入/输出特性的失真 对应于检测到的输出电流的LUT。 此外，根据LUT之间的切换方向，使用于切换LUT的阈值不同，从而抑制LUT的切换的频繁发生。
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公开(公告)号：US08219043B2
公开(公告)日：2012-07-10
申请号：US12644546
申请日：2009-12-22
申请人： Takatoshi Kawai , Kaoru Ishida
发明人： Takatoshi Kawai , Kaoru Ishida
IPC分类号： H04B1/00
CPC分类号： H04B1/0475 , H03F1/34 , H03F3/24 , H04B2001/0433
摘要： A radio transmission apparatus according to the present invention detects an output current of a power supply section that varies in response to a variation of the output impedance of an amplification section, and corrects a distortion of the input/output characteristic of the amplification section by using an LUT corresponding to the detected output current. In addition, a threshold used for switching an LUT is caused to be different depending on a switching direction between LUTs, thereby suppressing frequent occurrence of switching of the LUT.
摘要翻译： 根据本发明的无线电发送装置检测响应于放大部分的输出阻抗的变化而变化的电源部分的输出电流，并且通过使用来校正放大部分的输入/输出特性的失真 对应于检测到的输出电流的LUT。 此外，根据LUT之间的切换方向，使用于切换LUT的阈值不同，从而抑制LUT的切换的频繁发生。
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公开(公告)号：US07915306B2
公开(公告)日：2011-03-29
申请号：US10657910
申请日：2003-09-09
申请人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
发明人： Kenichi Chiba , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Ray Wood , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/335
CPC分类号： C07D493/04 , C07D313/00
摘要： The present invention provides compositions comprising compounds having formula (I): and additionally provides methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein. In certain embodiments, the compositions are for systemic (e.g., oral) administration. In certain embodiments, methods for the treatment of various disorders including inflammatory or autoimmune disorders comprise systemically (e.g., orally) administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I).
摘要翻译： 本发明提供了包含具有式（I）的化合物的组合物：另外提供了其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，X，Y， Z和n如本文所定义。 在某些实施方案中，组合物用于全身（例如口服）给药。 在某些实施方案中，用于治疗各种疾病（包括炎性或自身免疫性疾病）的方法包括全身（例如，口服）向有需要的受试者施用治疗有效量的式（I）化合物。
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公开(公告)号：US20130196987A1
公开(公告)日：2013-08-01
申请号：US13663857
申请日：2012-10-30
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D405/12 , C07D491/044 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds, methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis.
摘要翻译： 本发明提供了化合物，其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管生成的疾病的方法。
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公开(公告)号：US08219050B1
公开(公告)日：2012-07-10
申请号：US13433705
申请日：2012-03-29
申请人： Takatoshi Kawai , Kaoru Ishida
发明人： Takatoshi Kawai , Kaoru Ishida
IPC分类号： H04B1/04
CPC分类号： H04B1/0475 , H03F1/34 , H03F3/24 , H04B2001/0433
摘要： A radio transmission apparatus according to the present invention detects an output current of a power supply section that varies in response to a variation of the output impedance of an amplification section, and corrects a distortion of the input/output characteristic of the amplification section by using an LUT corresponding to the detected output current. In addition, a threshold used for switching an LUT is caused to be different depending on a switching direction between LUTs, thereby suppressing frequent occurrence of switching of the LUT.
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6.发明申请公开(公告)号：US20090012714A1
公开(公告)日：2009-01-08
申请号：US11659113
申请日：2005-08-04
申请人： Yasushi Ishihama , Takatoshi Kawai
发明人： Yasushi Ishihama , Takatoshi Kawai
IPC分类号： G01N33/68
摘要： It is an object of the present invention, when determining and identifying an amino acid sequence of a peptide using MS, to obtain additional information from the MS for evaluating validity of an amino acid sequence in a candidate list outputted from an identifying engine. The present invention provides a method of testing an amino acid sequence inferred by searching a peptide-related database based on peptide mass information and/or peptide modification information obtained through mass spectrometry on a peptide, the method comprising the steps: (1) calculating a theoretical value of an isotopic ratio for the peptide from the inferred amino acid sequence and/or the peptide modification information; (2) measuring a measured value of the isotopic ratio for the peptide from the peptide mass information; and (3) comparing the theoretical value and the measured value, and evaluating validity of the inferred amino acid sequence from differences between the theoretical value and the measured value.
摘要翻译： 本发明的目的是，当使用MS确定和鉴定肽的氨基酸序列时，从MS中获得用于评估从识别引擎输出的候选列表中的氨基酸序列的有效性的附加信息。 本发明提供了一种通过基于肽质量信息和/或通过质谱法获得的肽修饰信息在肽上搜索肽相关数据库来推断的氨基酸序列的方法，所述方法包括以下步骤：（1）计算 来自推断的氨基酸序列和/或肽修饰信息的肽的同位素比的理论值; （2）从肽质量信息测量肽的同位素比的测定值; 和（3）比较理论值和测量值，并根据理论值和测量值之间的差异评估推断的氨基酸序列的有效性。
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公开(公告)号：US20060247448A1
公开(公告)日：2006-11-02
申请号：US10507067
申请日：2003-03-07
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmanage , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-Andre Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： C07D313/08
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供具有式（I）的化合物：另外提供其合成方法及其用于治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R 1，R 11，X，Y，Z和n如本文所定义。
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公开(公告)号：US08329742B2
公开(公告)日：2012-12-11
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/355 , C07D313/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。
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公开(公告)号：US20110144101A1
公开(公告)日：2011-06-16
申请号：US12839873
申请日：2010-07-20
申请人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
发明人： Roch Boivin , Kenichi Chiba , Jesse Chow , Hong Du , Yoshihito Eguchi , Masanori Fujita , Masaki Goto , Fabian Gusovsky , Jean-Christophe Harmange , Atsushi Inoue , Yimin Jiang , Megumi Kawada , Takatoshi Kawai , Yoshiyuki Kawakami , Akifumi Kimura , Makoto Kotake , Yoshikazu Kuboi , Charles-André Lemelin , Xiang-Yi Li , Tomohiro Matsushima , Yoshiharu Mizui , Kenzo Muramoto , Hideki Sakurai , Yong-Chun Shen , Hiroshi Shirota , Mark Spyvee , Isao Tanaka , John (Yuan) Wang , Satoshi Yamamoto , Naoki Yoneda
IPC分类号： A61K31/5377 , A61K31/335 , A61K31/4184 , A61P29/00 , A61P37/00 , A61P17/06 , A61P11/06 , A61P35/00 , A61P1/00
CPC分类号： C07D405/12 , A61K31/335 , A61K31/36 , A61K31/395 , C07D231/12 , C07D233/56 , C07D249/08 , C07D313/00 , C07D401/12 , C07D491/04 , C07D491/044 , C07D493/04 , Y02A50/411
摘要： The present invention provides methods for the use of compounds having formula (I) in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, t, X, Y, Z, and n are as defined herein.
摘要翻译： 本发明提供了使用具有式（I）的化合物在治疗各种疾病（包括炎性或自身免疫性疾病）以及涉及恶性肿瘤或增加血管发生的疾病的方法，其中R1-R11，t，X，Y，Z和n 如本文所定义。
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公开(公告)号：US20100167798A1
公开(公告)日：2010-07-01
申请号：US12644546
申请日：2009-12-22
申请人： Takatoshi KAWAI , Kaoru Ishida
发明人： Takatoshi KAWAI , Kaoru Ishida
CPC分类号： H04B1/0475 , H03F1/34 , H03F3/24 , H04B2001/0433
摘要： A radio transmission apparatus according to the present invention detects an output current of a power supply section that varies in response to a variation of the output impedance of an amplification section, and corrects a distortion of the input/output characteristic of the amplification section by using an LUT corresponding to the detected output current. In addition, a threshold used for switching an LUT is caused to be different depending on a switching direction between LUTs, thereby suppressing frequent occurrence of switching of the LUT.
摘要翻译： 根据本发明的无线电发送装置检测响应于放大部分的输出阻抗的变化而变化的电源部分的输出电流，并且通过使用来校正放大部分的输入/输出特性的失真 对应于检测到的输出电流的LUT。 此外，根据LUT之间的切换方向，使用于切换LUT的阈值不同，从而抑制LUT的切换的频繁发生。
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