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    Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same
    1.
    发明授权
    Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same 失效
    杂环大环内酯药剂，其制备方法及其用途

    公开(公告)号：US07576204B2

    公开(公告)日：2009-08-18

    申请号：US10522733

    申请日：2003-07-31

    Applicant: Mitsuo Nagai ,  Masashi Yoshida ,  Toshio Tsuchida

    Inventor： Mitsuo Nagai ,  Masashi Yoshida ,  Toshio Tsuchida

    IPC: A61K31/497 ,  C07D411/00 ,  C07D313/04

    CPC classification number: C07D407/06

    Abstract: A compound represented by the following general formula (I): (I) wherein R7 and R21 are the same or different and each represents optionally substituted C2-22 alkoxy, etc.; a pharmaceutically acceptable salt thereof or hydrates of the same. The compound (1) inhibits angiogenesis and inhibits the production of VEGF particularly under hypoxic conditions, which makes it useful as a remedy for solid cancer.

    Abstract translation: 由以下通式（I）表示的化合物：（I）其中R 7和R 21相同或不同，各自表示任选取代的C 22-22烷氧基等。 其药学上可接受的盐或其水合物。 化合物（1）抑制血管发生并抑制VEGF的产生，特别是在缺氧条件下，其可用作固体癌的治疗剂。

    Method of manufacturing products of soymilk and apparatus of manufacturing the same
    3.
    发明授权
    Method of manufacturing products of soymilk and apparatus of manufacturing the same 失效
    制造豆浆制品的方法及其制造方法

    公开(公告)号：US07093534B2

    公开(公告)日：2006-08-22

    申请号：US10421816

    申请日：2003-04-24

    Applicant: Mitsuo Nagai ,  Osamu Moriyama

    Inventor： Mitsuo Nagai ,  Osamu Moriyama

    IPC: B30B9/06

    CPC classification number: A23L2/70 ,  A23C11/103 ,  A23L2/38 ,  A23L11/07

    Abstract: The invention comprises the steps of storing immersed or smothered raw material of soy beans including hulls in a storage chamber provided at the front part of a cylinder barrel, subsequently passing the stored raw material of soybeans through screens furnished at the front end of the cylinder barrel by driving a piston, and urging to press it out, thereby to manufacture a milk of the soy beans of the raw material being extremely refined. At this time, the screens are 60 to 500 meshes, and the pressure is 8.0 to 55.0 MPa.

    Abstract translation: 本发明包括以下步骤：将包括船体的大豆原料浸入或窒息的原料储存在设置在气缸筒前部的储存室中，随后将储存的大豆原料通过设在气缸筒前端的筛网 通过驱动活塞，并推压将其压出，从而制造原料的大豆的牛奶极其精炼。 此时，筛网为60〜500目，压力为8.0〜55.0MPa。

    Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound
    7.
    发明申请
    Intermediate in Production of [2-(3,3,5,5-Tetramethylcyclohexyl)phenyl]Piperazine Compound 审中-公开
    [2-（3,3,5,5-四甲基环己基）苯基]哌嗪化合物的制备中间体

    公开(公告)号：US20090163715A1

    公开(公告)日：2009-06-25

    申请号：US11920920

    申请日：2006-05-25

    Applicant: Mitsuo Nagai ,  Kazumasa Nara ,  Kazunori Wakasugi ,  Toshihiko Naito

    Inventor： Mitsuo Nagai ,  Kazumasa Nara ,  Kazunori Wakasugi ,  Toshihiko Naito

    IPC: C07D241/04 ,  C07C211/44 ,  C07D207/30 ,  C07D211/08 ,  C07C55/06 ,  C07C57/15 ,  C07C309/01

    CPC classification number: C07C233/05 ,  C07C211/45 ,  C07C233/25 ,  C07C275/32 ,  C07D295/033 ,  Y02P20/55

    Abstract: A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R1 and R2 independently represent hydrogen or a protecting group for an amino group, or R1 and R2 bond together to form an optionally substituted pyrrole ring.

    Abstract translation: 由以下通式表示的化合物或其盐是制备具有优异的细胞粘附抑制作用和细胞侵袭抑制作用的[2-（3,3,5,5-四甲基环己基）苯基]哌嗪化合物的有用中间体 因此可用作各种炎性疾病和由白细胞的粘附和侵入引起的自身免疫性疾病（例如炎性肠病（特别是溃疡性结肠炎或克罗恩病）），肠易激综合征，类风湿性关节炎，牛皮癣， 多发性硬化，哮喘和特应性皮炎。 其中R 1和R 2独立地表示氢或氨基的保护基，或者R 1和R 2一起形成任选取代的吡咯环。

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