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1.发明授权Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof 有权含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其制备方法及其用途公开(公告)号：US08765416B2
公开(公告)日：2014-07-01
申请号：US12875786
申请日：2010-09-03
IPC分类号： C12P19/44
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.
摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上; 并提供其制造方法及其用途。
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2.发明申请PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法公开(公告)号：US20140178943A9
公开(公告)日：2014-06-26
申请号：US13980223
申请日：2012-03-07
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
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3.发明申请HYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PARTICULATE COMPOSITION COMPRISING THE SAME, THEIR PREPARATION AND USES 有权水溶性结晶2-O-α-D-葡萄糖-L-抗坏血酸，包含它们的颗粒组合物，其制备和用途公开(公告)号：US20130172542A1
公开(公告)日：2013-07-04
申请号：US13821498
申请日：2011-09-06
申请人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
发明人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
IPC分类号： C07H19/01
CPC分类号： C07H19/01 , A23L33/15 , A61K8/602 , A61K9/145 , A61K31/7048 , A61K2800/10 , A61Q19/00 , A61Q19/02 , C07H17/04
摘要： The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.
摘要翻译： 本发明的目的是提供一种新的结晶2-O-α-葡糖基-L-抗坏血酸及其制备方法和用途，并通过提供含水结晶的2-O-α-葡糖基-L-抗坏血酸来解决上述目的 包含含水结晶的2-O-α-葡糖基-L-抗坏血酸的颗粒组合物及其制备方法和用途。
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4.发明授权Monoclonal antibodies specific for human interferon-alpha subtype alpha 8 失效对人类干扰素α亚型alpha 8具有特异性的单克隆抗体公开(公告)号：US08357782B2
公开(公告)日：2013-01-22
申请号：US12933768
申请日：2009-03-16
申请人： Shigeharu Fukuda , Chie Ushio , Harumi Ariyasu , Tohru Kayano , Toshio Ariyasu , Tsunetaka Ohta
发明人： Shigeharu Fukuda , Chie Ushio , Harumi Ariyasu , Tohru Kayano , Toshio Ariyasu , Tsunetaka Ohta
IPC分类号： C07K16/24 , A61K39/395 , C12N5/12
CPC分类号： C07K16/249 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/76 , G01N33/6866 , G01N2030/8831
摘要： The present invention has the first object to provide a monoclonal antibody specific to interferon α subtype α8 (IFNα8) and its mutant proteins, the second object to provide a hybridoma capable of producing the monoclonal antibody, the third object to provide a method for detecting the IFNα8 and its mutant proteins by the monoclonal antibody, the fourth object to provide a method for purifying the IFNα8 and its mutant proteins by the monoclonal antibody, and the fifth object to provide a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFNα8. The present invention solves the above objects by providing a monoclonal antibody specific to IFNα8 and its mutant proteins, a hybridoma capable of producing the monoclonal antibody, a method for detecting the IFNα8 and its mutant proteins by immunoreaction using the monoclonal antibody, a method for purifying the IFNα8 and its mutant proteins using the monoclonal antibody, and a therapeutic agent for treating diseases whose onsets or exacerbation are related with IFNα8, which contains the monoclonal antibody as an effective ingredient.
摘要翻译： 本发明的第一个目的是提供对干扰素α亚型α8（IFNα8）及其突变蛋白特异性的单克隆抗体，第二个目的是提供能产生单克隆抗体的杂交瘤，第三个目的是提供一种检测方法 通过单克隆抗体IFNα8及其突变蛋白，第四个目的是提供通过单克隆抗体纯化IFNα8及其突变蛋白的方法，第五个目的是提供一种用于治疗其发作或加重与IFNα8相关的疾病的治疗剂 。 本发明通过提供对IFNα8及其突变蛋白特异性的单克隆抗体，能够产生单克隆抗体的杂交瘤，通过使用单克隆抗体的免疫反应检测IFNα8及其突变蛋白的方法来解决上述目的，纯化方法 使用单克隆抗体的IFNα8及其突变蛋白，以及用于治疗其发作或恶化与IFNα8相关的疾病的治疗剂，其含有单克隆抗体作为有效成分。
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公开(公告)号：US20120329098A1
公开(公告)日：2012-12-27
申请号：US13590460
申请日：2012-08-21
IPC分类号： C12P19/24
摘要： The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.
摘要翻译： 本发明的目的是提供一种耐热纤维二糖2-差向异构酶，其制备和用途。 本发明通过提供热稳定性纤维二糖2-差向异构酶，编码该酶的DNA，重组DNA和包含该DNA的转化体，该酶的制备方法和使用该酶生产异构化糖的方法来实现上述目的。
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6.发明授权Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权形成葡聚糖的分支α-葡聚糖，α-葡萄糖基转移酶，其制备和应用公开(公告)号：US08324375B2
公开(公告)日：2012-12-04
申请号：US12597660
申请日：2008-04-23
申请人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C07H1/00 , C07H3/00 , C08B37/00 , A01N43/04 , A61K31/715 , C12P19/18 , C12P19/14 , C12N9/00 , C12N9/10
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。
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公开(公告)号：US20120040407A1
公开(公告)日：2012-02-16
申请号：US13147965
申请日：2010-01-25
摘要： The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.
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8.发明授权Skin preparation for external use characterized by containing sugar derivative of α, α-trehalose 有权外用皮肤制剂，其特征在于含有α，α-海藻糖的糖衍生物公开(公告)号：US07854922B2
公开(公告)日：2010-12-21
申请号：US10545166
申请日：2004-02-10
IPC分类号： A61K8/73 , A61K36/00 , A61K31/715 , A61K31/70 , A61K31/728
CPC分类号： A61Q19/02 , A61K8/0212 , A61K8/60 , A61K9/0014 , A61K31/702 , A61K31/716 , A61K45/06 , A61K47/26 , A61K2800/522 , A61Q1/02 , A61Q1/08 , A61Q1/10 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q11/00 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and/or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.
摘要翻译： 本发明的目的是提供具有令人满意的血液促进作用，抗炎作用，抗菌作用，保湿效果，美白效果，紫外线吸收效果，紫外线散射效果，抗氧化作用，发丝效果，毛发 滋养效果，呕吐效果，皱纹减轻效果，细胞活化作用和/或透皮吸收促进作用，具有令人满意的安全性和皮肤感觉; 本发明的目的是通过提供一种外用皮肤病学制剂，其包含α，α-海藻糖的糖衍生物和一种或多种选自具有血流促进作用，抗炎作用，抗菌作用，保湿作用，美白效果， 紫外线吸收效果，紫外线散射效果，抗氧化作用，毛发生长效果，滋养滋养效果，乳化作用，收敛效果，皱纹减轻效果，细胞活化作用和透皮吸收促进作用。
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公开(公告)号：US07811797B2
公开(公告)日：2010-10-12
申请号：US11797969
申请日：2007-05-09
CPC分类号： A23G1/40 , A21D2/181 , A23C9/005 , A23C9/1307 , A23C9/1544 , A23C9/156 , A23G3/42 , A23G4/10 , A23G9/34 , A23L2/60 , A23L15/00 , A23L15/20 , A23L27/30 , A23L33/10 , A23L33/21 , A61K8/60 , A61K8/66 , A61K9/0014 , A61K47/26 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07H3/04 , C07H3/06 , C12N9/1051 , C12N9/2425 , C12N9/2428 , C12P19/04 , C12Y302/01001 , C12Y302/01002 , C12Y302/01003 , C12Y302/0102
摘要： The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the α-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the α-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; α-isomaltosyl-transferring method using the enzyme; method for forming α-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(166)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(16} using both the α-isomaltosylglucosaccharide-forming enzyme and the α-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.
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10.发明授权Method of inhibiting 2,3-butanedione formation from processed cacao bean product 有权从加工可可豆制品中抑制2,3-丁二酮形成的方法公开(公告)号：US07790214B2
公开(公告)日：2010-09-07
申请号：US11578336
申请日：2005-04-11
申请人： Keiko Takeda , Sae Murai , Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda
发明人： Keiko Takeda , Sae Murai , Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda
IPC分类号： A23L1/36
摘要： The present invention has objects to provide a method of inhibiting the 2,3-butanedione formation in order to produce a satisfactorily flavorful processed cacao bean product and an agent for inhibiting the 2,3-butanedione formation which is used for the method, and solves the above objects by providing a method of inhibiting the 2,3-butanedione formation during the process and/or preservation, and an agent for inhibiting the 2,3-butanedione formation which comprises one or more members selected from the group consisting of maltitol, α,α-trehalose and saccharide derivatives of α,α-trehalose as effective ingredients.
摘要翻译： 本发明的目的是提供抑制2,3-丁二酮形成的方法，以制备令人满意的美味加工可可豆制品和用于该方法的2,3-丁二酮形成抑制剂， 通过提供在制备和/或保存期间抑制2,3-丁二酮形成的方法的上述目的，以及用于抑制2,3-丁二酮形成的试剂，其包含一种或多种选自麦芽糖醇， α，α-海藻糖和α，α-海藻糖的糖衍生物作为有效成分。
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