公开(公告)号：US20120084871A1

公开(公告)日：2012-04-05

申请号：US13026763

申请日：2011-02-14

Applicant: Scott Altmann ,  Xiaorui Yao ,  Kim Anne O'Neill ,  Brian E. Hawes

Inventor： Scott Altmann ,  Xiaorui Yao ,  Kim Anne O'Neill ,  Brian E. Hawes

IPC: A01K67/027 ,  C07K19/00 ,  C12N9/10 ,  C12N15/12 ,  C12N15/63 ,  C07K16/18 ,  A61K39/395 ,  C12N5/071 ,  A61K31/397 ,  C12P21/02 ,  G01N33/566 ,  A61K31/7052 ,  C12N1/21 ,  C12N5/10 ,  G01N33/92 ,  A61P3/00 ,  C07K14/47

CPC classification number: C07K14/705 ,  G01N33/92 ,  G01N2500/00

Abstract: The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.

Abstract translation: 本发明部分提供来自各种物种的NPC1L1。 还阐述了使用本文所述的NPC1L1多肽和多核苷酸的方法，例如在筛选测定中。

公开(公告)号：US07910698B2

公开(公告)日：2011-03-22

申请号：US11710295

申请日：2007-02-22

Applicant: Scott Altmann ,  Xiaorui Yao ,  Kim Ann O'Neill ,  Brian E. Hawes

Inventor： Scott Altmann ,  Xiaorui Yao ,  Kim Ann O'Neill ,  Brian E. Hawes

IPC: C07K14/00 ,  C12N11/00 ,  C12P21/06 ,  C12P21/04 ,  C12Q1/00 ,  G01N33/567 ,  G01N33/53 ,  G01N33/00 ,  C12Q1/16 ,  A01N37/18 ,  A61K38/16 ,  A61K38/00

CPC classification number: C07K14/705 ,  G01N33/92 ,  G01N2500/00

Abstract: The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.

Abstract translation: 本发明部分提供来自各种物种的NPC1L1。 还阐述了使用本文所述的NPC1L1多肽和多核苷酸的方法，例如在筛选测定中。

公开(公告)号：US20070021592A1

公开(公告)日：2007-01-25

申请号：US11523512

申请日：2006-09-19

Applicant: Scott Altmann ,  Nicholas Murgolo ,  Luquan Wang ,  Michael Graziano

Inventor： Scott Altmann ,  Nicholas Murgolo ,  Luquan Wang ,  Michael Graziano

IPC: C07K14/705 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06

CPC classification number: G01N33/92 ,  A01K2217/075 ,  C07K14/705

Abstract: The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.

Abstract translation: 本发明提供人，大鼠和小鼠NPC1L1多肽和编码多肽的多核苷酸。 还提供了用于检测NPC1L1的激动剂和拮抗剂的方法。 NPC1L1的抑制剂可用于抑制受试者肠内胆固醇的吸收。

公开(公告)号：US20070105141A1

公开(公告)日：2007-05-10

申请号：US11586303

申请日：2006-10-25

Applicant: Scott Altmann ,  Duane Burnett ,  Harry Davis ,  Michael Graziano ,  Maureen Laverty ,  Xiaorui Yao

Inventor： Scott Altmann ,  Duane Burnett ,  Harry Davis ,  Michael Graziano ,  Maureen Laverty ,  Xiaorui Yao

IPC: C40B30/06 ,  C40B40/08 ,  C40B40/10 ,  A61K31/397

CPC classification number: G01N33/502 ,  A61K31/397 ,  C12Q1/60 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/92 ,  G01N2333/4704

Abstract: The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.

Abstract translation: 使用作为胆固醇吸收抑制剂的氮杂环丁酮化合物作为用于发现和表征参与生物系统中胆固醇和/或胆固醇酯的运输或吸收的蛋白质的工具，这些化合物可用作竞争性结合测定的工具，以发现和表征其他 用作胆固醇吸收抑制剂的化学试剂。 本发明的新化合物也是胆固醇吸收的高效抑制剂。

公开(公告)号：US20050208568A1

公开(公告)日：2005-09-22

申请号：US11123615

申请日：2005-05-06

Applicant: Scott Altmann ,  Duane Burnett ,  Harry Davis ,  Michael Graziano ,  Maureen Laverty ,  Xiaorui Yao

Inventor： Scott Altmann ,  Duane Burnett ,  Harry Davis ,  Michael Graziano ,  Maureen Laverty ,  Xiaorui Yao

IPC: A61K31/397 ,  C12Q1/60 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/92

CPC classification number: G01N33/502 ,  A61K31/397 ,  C12Q1/60 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/92 ,  G01N2333/4704

Abstract: The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.