公开(公告)号：US20180170999A1

公开(公告)日：2018-06-21

申请号：US15737259

申请日：2016-06-29

申请人： Sanford-Burnham Medical Research Institute ,  PFIZER INC.

发明人： Carl F. Ware ,  John Sedy ,  Tigran Aivazian ,  Brian Miller ,  Natasha K. Crellin

IPC分类号： C07K14/71 ,  A61K38/17 ,  A61K45/06 ,  C07K14/705

CPC分类号： C07K14/71 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  C07K14/70578 ,  C07K2319/30

摘要： The present invention is based on the seminal discovery that BTLA agonist fusion proteins modulate an immune response. Specifically, the present invention provides fusion proteins that bind BTLA enhancing BTLA signaling The present invention further provides methods of treating cancer and immune and inflammatory diseases and disorders with a BTLA agonist fusion protein as described herein.

公开(公告)号：US20170334889A1

公开(公告)日：2017-11-23

申请号：US15672574

申请日：2017-08-09

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D.Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： C07D405/12 ,  C07C303/36 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/496 ,  C07D307/71 ,  A61K31/4525

摘要： N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US09776979B2

公开(公告)日：2017-10-03

申请号：US14910653

申请日：2014-09-26

申请人： Sanford-Burnham Medical Research Institute

发明人： Anthony B. Pinkerton ,  Robert Ardecky ,  Eduard A. Sergienko ,  Marcos Gonzalez-Lopez ,  Santhi Reddy Ganji ,  Jiwen Zou

IPC分类号： C07D295/16 ,  C07D471/04 ,  C07D471/10 ,  C07F5/02 ,  C07D209/12 ,  C07D211/26 ,  C07D215/14 ,  C07D235/10 ,  C07D257/04 ,  C07D295/26 ,  C07D317/46 ,  C07D333/56 ,  C07D401/06 ,  C07D403/12 ,  C07D495/04 ,  C07F9/6509

CPC分类号： C07D295/16 ,  C07D209/12 ,  C07D211/26 ,  C07D215/14 ,  C07D235/10 ,  C07D257/04 ,  C07D295/26 ,  C07D317/46 ,  C07D333/56 ,  C07D401/06 ,  C07D403/12 ,  C07D471/04 ,  C07D471/10 ,  C07D495/04 ,  C07F5/025 ,  C07F9/650952

摘要： Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds. EBI2 is a therapeutic target for the treatment of a variety of diseases or conditions. In some embodiments, EBI2 is a therapeutic target for the treatment of diseases or conditions such as, but not limited to, autoimmune diseases or conditions, cancer, and cardiovascular disease.

公开(公告)号：US09732067B2

公开(公告)日：2017-08-15

申请号：US14408736

申请日：2013-06-18

申请人： University of Kansas ,  The Regents of the University of Michigan ,  Wayne State University ,  Sanford-Burnham Medical Research Institute

发明人： Jennifer E. Golden ,  Jeffrey Aube ,  Daniel P. Flaherty ,  Andrew M. Fribley ,  Randal J. Kaufman ,  Thomas D. Y. Chung ,  Anthony B. Pinkerton ,  Michael Pablo Hedrick

IPC分类号： C07D405/12 ,  C07C303/36 ,  A61K31/4525 ,  C07D307/71 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06

CPC分类号： C07D405/12 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C303/36 ,  C07D307/71

摘要： N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

公开(公告)号：US09522198B2

公开(公告)日：2016-12-20

申请号：US14331048

申请日：2014-07-14

申请人： Sanford-Burnham Medical Research Institute

发明人： Erkki Ruoslahti ,  Jan Pilch

IPC分类号： C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K19/00 ,  A61K38/04 ,  A61K38/08 ,  A61K38/16 ,  A61K38/17 ,  A61K49/00 ,  A61K47/48 ,  A61K49/08 ,  A61K49/14 ,  A61K38/12 ,  A61K38/10

CPC分类号： A61K49/0056 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K38/17 ,  A61K47/64 ,  A61K49/0043 ,  A61K49/085 ,  A61K49/14 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/035

摘要： Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sties of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.

摘要翻译： 公开了用于靶向肿瘤，损伤部位和血块的组合物和方法。 组合物和方法基于肽序列，其选择性地结合动物的肿瘤，损伤和血块的肿瘤和家庭。 所公开的靶向对于将治疗和可检测的药物递送到肿瘤，损伤部位和血块是有用的。

公开(公告)号：US20160355479A1

公开(公告)日：2016-12-08

申请号：US15241905

申请日：2016-08-19

申请人： Sanford-Burnham Medical Research Institute

发明人： Anthony B. PINKERTON ,  Russell DAHL ,  Nicholas D.P. COSFORD ,  Jose Luis MILLAN

IPC分类号： C07D213/76 ,  C07D405/12 ,  C07D401/12 ,  C07D215/38 ,  C07D215/48 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  C07D213/79 ,  C07D213/81 ,  C07D409/12 ,  C07D401/04

CPC分类号： C07D213/76 ,  A61K31/44 ,  A61K31/50 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D215/38 ,  C07D215/48 ,  C07D231/42 ,  C07D237/20 ,  C07D239/69 ,  C07D241/22 ,  C07D261/16 ,  C07D263/50 ,  C07D271/113 ,  C07D277/52 ,  C07D285/135 ,  C07D333/36 ,  C07D401/04 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04

摘要： Described herein are compounds that modulate the activity of TNAP. In some embodiments, the compounds described herein inhibit TNAP. In certain embodiments, the compounds described herein are useful in the treatment of conditions associated with hyper-mineralization.

公开(公告)号：US09266828B2

公开(公告)日：2016-02-23

申请号：US14385714

申请日：2013-03-14

申请人： Sanford-Burnham Medical Research Institute

发明人： Alex Strongin ,  Maurizio Pellecchia ,  Elisa Barile

IPC分类号： C07C279/04 ,  A61K31/155 ,  A61P35/00 ,  C07C317/50 ,  A61K38/00 ,  C07K5/09 ,  C07K5/062

CPC分类号： C07C317/50 ,  A61K38/00 ,  C07K5/06034 ,  C07K5/0817 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/469

摘要： Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed.

摘要翻译： 本文公开了用于抑制弗林蛋白酶和其它丙型蛋白质转化酶的弗林蛋白/ PC抑制剂。 还公开了制备Furin / PC抑制剂的方法，Furin / PC抑制剂的化学和生物学表征，以及使用Furin / PC抑制剂治疗感染性疾病，癌症和炎性/自身免疫性疾病。

公开(公告)号：US20160022831A1

公开(公告)日：2016-01-28

申请号：US14664910

申请日：2015-03-22

申请人： SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

发明人： Lianglin Zhang ,  Jason Hoffman ,  Erkki Ruoslahti

IPC分类号： A61K47/48 ,  A61K38/08 ,  C07K7/06

CPC分类号： A61K38/08 ,  A61K38/00 ,  A61K38/04 ,  A61K47/6849 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof.

摘要翻译： 本发明提供了多种分离的肽和肽模拟物，其可用于构建本发明的缀合物，或其中肽本身具有生物学活性的非共轭形式作为治疗各种各样的 心血管疾病如下所述。 因此，本发明提供长度小于60个残基的分离的肽或肽模拟物，并且包括氨基酸序列CRPPR（SEQ ID NO：1）或其肽模拟物。 本发明还提供长度小于60个残基的分离的肽或肽模拟物，包括氨基酸序列CARPAR（SEQ ID NO：5）或其拟肽，或氨基酸序列CPKRPR（SEQ ID NO：6）或 其拟肽。

公开(公告)号：US20150212086A1

公开(公告)日：2015-07-30

申请号：US14396414

申请日：2013-04-25

申请人： Sanford Burnham Medical Research Institute

发明人： Erkki Ruoslahti ,  Pirjo Laakkonen

IPC分类号： G01N33/574 ,  A61K45/06 ,  A61K39/395 ,  A61K31/713 ,  C07K16/18 ,  C12N15/113

CPC分类号： G01N33/57407 ,  A61K31/713 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531 ,  G01N2333/4704 ,  G01N2800/52 ,  G01N2800/56

摘要： Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

摘要翻译： 已经鉴定出癌细胞上的细胞靶标可用于靶向分子成像以检测体内的癌细胞。 因此，提供了用于检测癌细胞的非侵入性方法，例如转移的癌细胞。 还提供了用于所公开的方法中的组合物和试剂盒。

公开(公告)号：US20140377184A1

公开(公告)日：2014-12-25

申请号：US14331048

申请日：2014-07-14

申请人： Sanford-Burnham Medical Research Institute

发明人： Erkki Ruoslahti ,  Jan Pilch

IPC分类号： A61K49/00 ,  A61K47/48 ,  C07K7/06

CPC分类号： A61K49/0056 ,  A61K38/08 ,  A61K38/10 ,  A61K38/12 ,  A61K38/16 ,  A61K38/17 ,  A61K47/64 ,  A61K49/0043 ,  A61K49/085 ,  A61K49/14 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/035

摘要： Disclosed are compositions and methods useful for targeting tumors, sites of injury and blood clots. The compositions and methods are based on peptide sequences that selectively bind to and home to tumors, sties of injury and blood clots in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tumors, sites of injury and blood clots.

摘要翻译： 公开了用于靶向肿瘤，损伤部位和血块的组合物和方法。 组合物和方法基于肽序列，其选择性地结合动物的肿瘤，损伤和血块的肿瘤和家庭。 所公开的靶向对于将治疗和可检测的药物递送到肿瘤，损伤部位和血块是有用的。