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公开(公告)号：US20130237692A1
公开(公告)日：2013-09-12
申请号：US13785632
申请日：2013-03-05
申请人： Jiali Liao , Russell Frost
发明人： Jiali Liao , Russell Frost
CPC分类号： B01J41/20 , B01D15/265 , B01D15/30 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/22 , B01J20/267 , B01J20/28016 , B01J20/281 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3253 , B01J20/3265 , B01J20/3293 , B01J41/04 , B01J41/09 , B01J2220/52 , C07K1/14 , C07K1/16 , C07K1/165 , C07K16/00 , G01N30/482
摘要： Anion exchange-hydrophobic mixed mode ligands and methods of their use are provided.
摘要翻译： 提供了阴离子交换 - 疏水混合模式配体及其使用方法。
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公开(公告)号：US09669402B2
公开(公告)日：2017-06-06
申请号：US13785632
申请日：2013-03-05
申请人： Jiali Liao , Russell Frost
发明人： Jiali Liao , Russell Frost
IPC分类号： B01D15/26 , C07K1/14 , B01J20/281 , B01J41/20 , C07K1/16 , B01D15/30 , B01D15/32 , B01D15/36 , B01D15/38 , B01J20/286 , B01J20/289 , B01J20/32
CPC分类号： B01J41/20 , B01D15/265 , B01D15/30 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/22 , B01J20/267 , B01J20/28016 , B01J20/281 , B01J20/286 , B01J20/288 , B01J20/289 , B01J20/3208 , B01J20/3217 , B01J20/3219 , B01J20/3253 , B01J20/3265 , B01J20/3293 , B01J41/04 , B01J41/09 , B01J2220/52 , C07K1/14 , C07K1/16 , C07K1/165 , C07K16/00 , G01N30/482
摘要： Solid supports and ligands are provided for purification of biomolecules by mixed-mode anion exchange-hydrophobic chromatography. Compositions can have the formula Support-(X)—N(R1, R2)—R3-L-Ar, or a salt thereof, wherein: Support is a chromatographic solid support; X is a spacer or absent; R1 and R2 are each selected from hydrogen and an alkyl comprising 1-6 carbons; R3 is an alkyl comprising 1-6 carbons or a cyclo alkyl comprising 1-6 carbons; L is NR4, O, or S; wherein R4 is hydrogen or an alkyl comprising 1-6 carbons; and Ar is an aryl. Methods are also provided for using solid supports and ligands to purify biomolecules such as monomeric antibodies.
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