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1.发明授权Method of treating an ischemia-reperfusion injury-related disorder by administering GPCR ligands 有权通过施用GPCR配体治疗缺血再灌注损伤相关疾病的方法公开(公告)号：US08828940B2
公开(公告)日：2014-09-09
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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2.发明申请NOVEL NUCLEOTIDE AND AMINO ACID SEQUENCES, AND ASSAYS AND METHODS OF USE THEREOF FOR DIAGNOSIS OF BREAST CANCER 审中-公开新型核酸和氨基酸序列及其用于诊断乳腺癌的测定及其使用方法公开(公告)号：US20090286957A1
公开(公告)日：2009-11-19
申请号：US12350814
申请日：2009-01-08
申请人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
发明人： Amir Toporik , Dvir Dahary , Rotem Sorek , Sarah Pollock , Zurit Levine , Pinchas Akiva , Alexander Diber , Amit Novik , Osnat Sella-Tavor , Michal Ayalon-Soffer , Shira Walach , Shirley Sameah-Greenwald , Ronen Shemesh , Naomi Keren , Maxim Shklar
IPC分类号： C07K14/435
CPC分类号： G01N33/57415 , C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between breast cancer and non-cancerous states.
摘要翻译： 乳腺癌的新型标记物既敏感又准确。 这些标志物在乳腺癌中特异性地过表达，与正常的乳腺组织相反。 这些标记物在患者样本中单独或组合的测量提供了诊断者可以与乳腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示乳腺癌与非癌状态之间的高度差异检测。
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公开(公告)号：US20060068405A1
公开(公告)日：2006-03-30
申请号：US11043860
申请日：2005-01-27
申请人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
发明人： Alex Diber , Sarah Pollock , Zurit Levine , Sergey Nemzer , Vladimir Grebinskiy , Brian Meloon , Andrew Olson , Avi Rosenberg , Ami Haviv , Shaul Zevin , Tomer Zekharia , Zipi Shaked , Moshe Olshansky , Ariel Farkash , Eyal Privman , Amit Novik , Naomi Keren , Gad Cojocaru , Pinchas Akiva , Yossi Cohen , Ronen Shemesh , Osnat Sella-Tavor , Liat Mintz , Hanqing Xie , Dvir Dahary , Erez Levanon , Shiri Freilich , Nili Beck , Wei-Yong Zhu , Alon Wasserman , Chen Chermesh , Idit Azar , Rotem Sorek , Jeanne Bernstein
CPC分类号： C07K14/705 , G16B25/00 , G16B30/00 , G16B50/00
摘要： Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
摘要翻译： 提供多肽序列和多核苷酸序列。 还提供了关于这些序列的这些序列和用途的注释信息。
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4.发明申请Splice variants of peptide YY, neuropeptide Y, pancreatic peptide Y and Amylin, and uses thereof 审中-公开肽YY，神经肽Y，胰肽Y和胰岛淀粉样多肽的剪接变体及其用途公开(公告)号：US20060052301A1
公开(公告)日：2006-03-09
申请号：US11145463
申请日：2005-06-02
申请人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
发明人： Ronen Shemesh , Yossef Kliger , Lewis Neville , Jeanne Bernstein , Dani Eshel
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , C07K14/57545 , C07K16/26 , C07K2319/00
摘要： The present invention relates to alternative splice variants of Amylin and members of the Pancreatic Polypeptide family, namely PYY, NPY, and PPY, vectors and compositions that include the same, and methods of use thereof. This invention provides peptides, nucleic acid sequences which encode same, analogs and derivatives thereof, antibodies which specifically recognize the variant sequences, compositions that include the same and methods of use thereof.
摘要翻译： 本发明涉及胰岛淀粉样多肽的选择性剪接变体和胰腺多肽家族的成员，即PYY，NPY和PPY，包含其的载体和组合物及其使用方法。 本发明提供肽，其编码相同的核酸序列，其类似物和衍生物，特异性识别变体序列的抗体，包括其的组合物及其使用方法。
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公开(公告)号：US09428586B2
公开(公告)日：2016-08-30
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , C12N15/113 , C12N9/24
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20140056811A1
公开(公告)日：2014-02-27
申请号：US13976502
申请日：2011-12-26
申请人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
发明人： Etai Jacob , Amir Toporik , Ronen Shemesh , Ofer Levy
IPC分类号： A61K47/48
CPC分类号： C07K14/78 , A61K47/62 , C07K14/47 , C07K2319/01
摘要： The present invention is related to peptides, which are suitable for use as cell-penetrating peptides (CPPs), variants thereof and/or complexes, fusion molecules and/or conjugates comprising same, use thereof for manufacture of compositions for diagnosing, treating and/or preventing of medical conditions.
摘要翻译： 本发明涉及适合用作细胞穿透肽（CPP），其变体和/或复合物，包含其的融合分子和/或缀合物的肽，其用于制备用于诊断，治疗和/ 或预防医疗状况。
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公开(公告)号：US20120301475A1
公开(公告)日：2012-11-29
申请号：US13512921
申请日：2010-11-30
申请人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
发明人： Ronen Shemesh , Michal Ayalon-Soffer , Zurit Levine , Sergey Nemzer , Tomer Zekharya , Gad S. Cojocaru , Uri Barash , Neta Ilan , Israel Vlodavsky , Iris Hecht
IPC分类号： C07K16/40 , G01N33/573 , G01N33/574 , A61N5/00 , A61K39/395 , A61P35/00 , A61P35/02 , C12N5/20 , C12Q1/70
CPC分类号： C07K16/30 , C07K16/40 , C12N9/2402 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12Y302/01166
摘要： The present invention, in at least some aspects, is of splice variants of heparanase, as well as diagnostic kits and methods of use, and therapeutic agents and methods of use based thereon, and antibodies specifically binding thereof.
摘要翻译： 在至少一些方面，本发明是肝素酶的剪接变体，以及诊断试剂盒和使用方法，以及基于其的治疗剂和使用方法以及与其特异性结合的抗体。
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公开(公告)号：US20120129776A1
公开(公告)日：2012-05-24
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/08 , C07K14/47 , C07K7/08 , C07K2/00 , C07H21/00 , A61K48/00 , C07K16/18 , A61P9/12 , A61P9/00 , A61P9/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P3/00 , A61P11/00 , A61P17/02 , A61P19/08 , A61P13/02 , A61P15/00 , A61P7/00 , A61P37/00 , A61P35/00 , A61P13/12 , A61P17/14 , A61P21/00 , A61P9/04 , C07K19/00 , A61P7/02 , A61K38/17 , C07K7/06
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US20100184839A1
公开(公告)日：2010-07-22
申请号：US12598286
申请日：2008-04-30
申请人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
发明人： Avishay Vaknin , Pini Akiva , Sarah Pollock , Lily Bazak , Erez Levanon , Tomer Zekharya , Alex Golubev , Gady Cojocaru , Liat Dassa , Sarit Edelheit-Flohr , Ronen Shemesh , Anat Amir , Yossi Cohen
IPC分类号： A61K31/7088 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The invention relates to the identification of allelic polymorphism in a diabetes associated gene, particularly in a gene encoding phosphofructokinase (PFK) and use thereof for diagnosing diabetes predisposition and state and for predicting the response to a therapeutic agent.
摘要翻译： 本发明涉及鉴定糖尿病相关基因中的等位基因多态性，特别是在编码磷酸果糖激酶（PFK）的基因中的等位基因多态性及其用于诊断糖尿病倾向和状态以及预测对治疗剂的应答的用途。
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