公开(公告)号：US08575107B2

公开(公告)日：2013-11-05

申请号：US12863864

申请日：2009-01-22

Applicant: Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

Inventor： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

IPC: C07K9/00 ,  A61K38/00

CPC classification number: C07K14/775 ,  A61K38/00

Abstract: Clusterin-derived peptides or homologues or derivatives thereof, pharmaceutical compositions including the same, methods of manufacturing the peptides, homologues, derivatives thereof and compositions including the same, and methods of treating conditions including administering the peptides, homologues, derivatives thereof and compositions including the same, are provided. Also provided are nucleotide sequences encoding the peptides, homologues, derivatives thereof and compositions including the same, antibodies directed to epitopes thereof and fusion proteins including the same.

Abstract translation: 来自Clusterin的肽或其同系物或衍生物，包含其的药物组合物，制备肽的方法，同系物，其衍生物和包含其的组合物，以及治疗包括给予所述肽，同系物，衍生物和包括 相同，被提供。 还提供了编码肽，同系物，其衍生物和包含其的组合物的核苷酸序列，涉及其表位的抗体和包括其的融合蛋白。

公开(公告)号：US08529943B2

公开(公告)日：2013-09-10

申请号：US13054914

申请日：2009-07-20

Applicant: Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

Inventor： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

IPC: C07K14/515 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/46 ,  A61K38/16 ,  A61K38/08 ,  A61K38/10

CPC classification number: C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

Abstract: Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

Abstract translation: 提供来自血管生成素的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，治疗各种病症，疾病和疾病的方法，编码它们的核苷酸序列， 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US20100184839A1

公开(公告)日：2010-07-22

申请号：US12598286

申请日：2008-04-30

Applicant: Avishay Vaknin ,  Pini Akiva ,  Sarah Pollock ,  Lily Bazak ,  Erez Levanon ,  Tomer Zekharya ,  Alex Golubev ,  Gady Cojocaru ,  Liat Dassa ,  Sarit Edelheit-Flohr ,  Ronen Shemesh ,  Anat Amir ,  Yossi Cohen

Inventor： Avishay Vaknin ,  Pini Akiva ,  Sarah Pollock ,  Lily Bazak ,  Erez Levanon ,  Tomer Zekharya ,  Alex Golubev ,  Gady Cojocaru ,  Liat Dassa ,  Sarit Edelheit-Flohr ,  Ronen Shemesh ,  Anat Amir ,  Yossi Cohen

IPC: A61K31/7088 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: The invention relates to the identification of allelic polymorphism in a diabetes associated gene, particularly in a gene encoding phosphofructokinase (PFK) and use thereof for diagnosing diabetes predisposition and state and for predicting the response to a therapeutic agent.

Abstract translation: 本发明涉及鉴定糖尿病相关基因中的等位基因多态性，特别是在编码磷酸果糖激酶（PFK）的基因中的等位基因多态性及其用于诊断糖尿病倾向和状态以及预测对治疗剂的应答的用途。

公开(公告)号：US20110206760A1

公开(公告)日：2011-08-25

申请号：US13054914

申请日：2009-07-20

Applicant: Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

Inventor： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

IPC: A61K38/16 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/46 ,  A61K38/08 ,  A61K38/10 ,  A61K9/127 ,  A61P27/02 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P9/00 ,  A61K39/395 ,  A61K38/27 ,  A61K38/20 ,  A61K38/21 ,  A61K33/24 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  A61P11/06 ,  A61P7/06 ,  B82Y5/00

CPC classification number: C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

Abstract: Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

Abstract translation: 提供来自血管生成素的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，治疗各种病症，疾病和疾病的方法，编码它们的核苷酸序列， 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US20110189188A1

公开(公告)日：2011-08-04

申请号：US12921920

申请日：2009-03-12

Applicant: Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Anat Amir ,  Anat Oren

Inventor： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Anat Amir ,  Anat Oren

IPC: A61K39/395 ,  C07K14/00 ,  A61K38/16 ,  C07K16/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P3/10 ,  A61P1/04 ,  A61P19/02 ,  A61P17/06

CPC classification number: C07K14/4703 ,  A61K38/00

Abstract: Provided is a gp96-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

Abstract translation: 提供了gp96衍生的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，用于治疗广泛的病症，疾病和疾病的方法，编码它们的核苷酸序列 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US08512708B2

公开(公告)日：2013-08-20

申请号：US12921920

申请日：2009-03-12

Applicant: Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Anat Amir ,  Anat Oren

Inventor： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Anat Amir ,  Anat Oren

IPC: A61K39/00

CPC classification number: C07K14/4703 ,  A61K38/00

Abstract: Provided is a gp96-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

Abstract translation: 提供了gp96衍生的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，用于治疗广泛的病症，疾病和疾病的方法，编码它们的核苷酸序列 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US20100322938A1

公开(公告)日：2010-12-23

申请号：US12863864

申请日：2009-01-22

Applicant: Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

Inventor： Yossef Kliger ,  Ofer Levy ,  Itamar Borukhov ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Zohar Tiran ,  Anat Oren ,  Amir Toporik

IPC: A61K39/395 ,  C07K14/00 ,  C07K16/00 ,  C07H21/04 ,  A61P25/28

CPC classification number: C07K14/775 ,  A61K38/00

Abstract: Clusterin-derived peptides or homologues or derivatives thereof, pharmaceutical compositions including the same, methods of manufacturing the peptides, homologues, derivatives thereof and compositions including the same, and methods of treating conditions including administering the peptides, homologues, derivatives thereof and compositions including the same, are provided. Also provided are nucleotide sequences encoding the peptides, homologues, derivatives thereof and compositions including the same, antibodies directed to epitopes thereof and fusion proteins including the same

Abstract translation: 来自Clusterin的肽或其同系物或衍生物，包含其的药物组合物，制备肽的方法，同系物，其衍生物和包含其的组合物，以及治疗包括给予所述肽，同系物，衍生物和包括 相同，被提供。 还提供了编码肽，同系物，其衍生物和包含其的组合物的核苷酸序列，针对其表位的抗体和包含其的融合蛋白