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公开(公告)号：US20150124734A1
公开(公告)日：2015-05-07
申请号：US14406051
申请日：2012-06-21
申请人： Thomas Olsson , Peter Brauer , Anders Carlsson , Roland Carlsson , David Engdal , Henrik Sahlin , Jim Svensson
发明人： Thomas Olsson , Peter Brauer , Anders Carlsson , Roland Carlsson , David Engdal , Henrik Sahlin , Jim Svensson
CPC分类号： H04W74/0833 , H04W72/04 , H04W74/002
摘要： The present invention relates to method and arrangement in cellular mobile communication systems, in particular for handling of a physical random access channel for example in a Long Term Evolution communication network. By sending to at least one user equipment, UE, in a communication network cell an un-solicited speculative random access response, RAR, message comprising information relating to at least one of pre-amble identifier, allocated UE identifier, and uplink resource allocation data for L2/L3 message, it is possible to reduce the complexity of the access node, e.g. an eNodeB.
摘要翻译： 本发明涉及蜂窝移动通信系统中的方法和装置，特别是用于处理例如长期演进通信网络中的物理随机接入信道。 通过向通信网络小区中的至少一个用户设备UE发送未请求的推测随机接入响应RAR消息，其包括与前同步标识符，分配的UE标识符和上行链路资源分配数据中的至少一个相关的信息 对于L2 / L3消息，可以降低接入节点的复杂度，例如 一个eNodeB。
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公开(公告)号：US08488485B2
公开(公告)日：2013-07-16
申请号：US12994332
申请日：2008-05-23
申请人： Roland Carlsson , Aare Mällo
发明人： Roland Carlsson , Aare Mällo
IPC分类号： H04L12/26
CPC分类号： H04L43/16 , H04L43/0852 , H04L2001/0097
摘要： An intermediary node is adapted for receiving a sequence of packets from a server, wherein the intermediary node comprises a time estimator adapted for performing the following steps—resolving the sequence number (k) and time of arrival to the intermediary node for at least a plurality (q) of incoming packets; establishing the frame period of the incoming packets (T); establishing a sequence of normalized packet arrival times (ek) as corresponding to the established frame period (T); calculating the relative arrival time (rtrec, k) of the plurality (q) of incoming packets in relation to the normalized packet arrival times; creating a cumulative density function (CDF) for a given sequence of packets; and establishing the threshold value for the relative arrival time (rtPL) yielding the predefined packet loss (PL) based on the cumulative density function (CDF).
摘要翻译： 中间节点适于从服务器接收分组序列，其中中间节点包括适于执行以下步骤的时间估计器 - 将至少多个节点的序列号（k）和到达中间节点的时间解析 （q）传入分组; 建立传入分组（T）的帧周期; 建立与建立的帧周期（T）相对应的归一化分组到达时间（ek）的序列; 计算相对于归一化分组到达时间的多个（q）输入分组的相对到达时间（rtrec，k） 为给定的包序列创建累积密度函数（CDF）; 以及基于累积密度函数（CDF）建立产生预定义分组丢失（PL）的相对到达时间（rtPL）的阈值。
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3.发明授权公开(公告)号：US08114966B2
公开(公告)日：2012-02-14
申请号：US12258745
申请日：2008-10-27
申请人： Jan Nilsson , Roland Carlsson , Jenny Bengtsson , Leif Strandberg
发明人： Jan Nilsson , Roland Carlsson , Jenny Bengtsson , Leif Strandberg
CPC分类号： C07K14/775 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to passive immunization for treating or preventing atherosclerosis using an isolated human antibody directed towards at least one oxidized fragment of apolipoprotein B in the manufacture of a pharmaceutical composition for therapeutical or prophylactical treatment of atherosclerosis by means of passive immunization, as well as method for preparing such antibodies, and a method for treating a mammal, preferably a human using such an antibody to provide for passive immunization.
摘要翻译： 本发明涉及用于治疗或预防动脉粥样硬化的被动免疫，其使用针对至少一种载脂蛋白B的氧化片段的分离的人抗体制造用于通过被动免疫治疗或预防性治疗动脉粥样硬化的药物组合物，以及 制备这种抗体的方法，以及使用这种抗体治疗哺乳动物，优选人的方法以提供被动免疫。
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公开(公告)号：US20110262461A1
公开(公告)日：2011-10-27
申请号：US13053846
申请日：2011-03-22
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , C12N5/078 , A61P31/18 , A61P35/00 , A61P35/02 , A61P29/00 , A61P37/06 , A61P31/00 , C12N5/071 , C12N5/0781
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2821 , C07K16/2833 , C07K16/4283 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/94
摘要： The invention provides binding molecules, including antibody molecules which selectively bind to a cell surface antigen of a target cell, and wherein the binding molecules, on binding the cell surface antigen, induce apoptosis of the target cell. There is also provided methods of and pharmaceutical compositions for apoptosis induction and uses thereof.
摘要翻译： 本发明提供了结合分子，包括选择性结合靶细胞的细胞表面抗原的抗体分子，并且其中结合分子在细胞表面抗原结合时诱导靶细胞凋亡。 还提供了用于凋亡诱导的方法和药物组合物及其用途。
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公开(公告)号：US20090208503A1
公开(公告)日：2009-08-20
申请号：US12065413
申请日：2006-09-04
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , A01K67/027 , C07K16/18
CPC分类号： C07K16/18 , A61K39/0012 , A61K2039/505 , C07K16/44 , C07K2317/21 , C07K2317/30 , C07K2317/622 , Y02A50/407
摘要： The use of immunotherapy against oxidised LDL to induce regression of pre-existing atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.
摘要翻译： 使用针对氧化LDL的免疫治疗来诱导个体中先前存在的动脉粥样硬化病变的消退。 免疫治疗可以是使用与氧化的LDL上存在的表位结合的抗体的免疫治疗，或使用疫苗组合物的活性免疫治疗来诱导针对氧化的LDL上存在的表位的免疫应答。
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公开(公告)号：US07563578B2
公开(公告)日：2009-07-21
申请号：US11858429
申请日：2007-09-20
CPC分类号： C12N15/10 , C12N15/1027
摘要： The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3′ and 5′ ends of at least one of the parent polynucleotides under annealing conditions; d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
摘要翻译： 本发明提供了从编码一种或多种蛋白质基序的母体单链多核苷酸序列产生多核苷酸序列或序列群的方法，包括以下步骤：a）提供构成母体多核苷酸序列的正负链的单链DNA; b）用不同于DNase I的核酸酶消化单链多核苷酸序列以产生单链片段群; c）将由正链产生的所述片段与由负链产生的片段接触，并任选地加入在退火条件下退火至少一种母体多核苷酸的3'和5'末端的引物序列; d）与由所述亲本多核苷酸编码的一种或多种蛋白质基序相比，扩增彼此退火的片段以产生编码一种或多种具有改变的特征的蛋白质基序的至少一个多核苷酸序列。
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公开(公告)号：US07563437B2
公开(公告)日：2009-07-21
申请号：US11353293
申请日：2006-02-13
IPC分类号： A61K39/395
CPC分类号： C07K16/1072 , C07K2317/92
摘要： A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.
摘要翻译： 单个分离的抗体或其抗体片段结合HIV-1多重菌株和亚型中显示的HIV-1 Tat蛋白的表位内的多个变体序列。 这种“泛表位”抗体可用于HIV-1感染的治疗和预防组合物和治疗，不管应变如何。 该泛表位抗体可用于基于生物样品中Tat蛋白量的测量来检测HIV-1水平的测定中。
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8.发明授权Method and arrangement for minimizing intracell interference in a data transmission system 有权用于最小化数据传输系统中的小区干扰的方法和装置公开(公告)号：US07542722B2
公开(公告)日：2009-06-02
申请号：US10583456
申请日：2003-12-19
申请人： Roland Carlsson
发明人： Roland Carlsson
IPC分类号： H04B3/10 , H04B7/212 , H04B1/00 , H04J3/12 , H04J11/00 , H04J3/00 , H04J4/00 , H04Q7/20 , H04Q7/00 , G01S3/02
CPC分类号： H04W72/082 , H04W16/02 , H04W16/10 , H04W16/24 , H04W64/00 , H04W72/0413 , H04W72/0446
摘要： An arrangement and a method for minimizing intracell and/or intercell interference for a data transmission system comprises a scheduler (2). A first base station (BS) receives information from user equipments (UE1-UE4) in a first cell (1) by means of a first antenna system (Rx, Tx). The scheduler (2) identifies the position of each user and allots a first time slot (TS1) to at least one user equipment (UE1) in a first cell segment (CS1) in the first cell (1). The scheduler (2) also allots the first time slot to at least one user (UE3) equipment in a second cell segment (CS2) in the first cell (1). The antenna system (Rx, Tx) then sends information from the base station (BS) simultaneously to all user equipments (UE1, UE3) allotted to the first time slot.
摘要翻译： 用于最小化数据传输系统的小区内和/或小区间干扰的装置和方法包括调度器（2）。 第一基站（BS）借助于第一天线系统（Rx，Tx）从第一小区（1）中的用户设备（UE1-UE4）接收信息。 调度器（2）识别每个用户的位置，并将第一时隙（TS1）分配给第一小区（1）中的第一小区段（CS1）中的至少一个用户设备（UE1）。 调度器（2）还向第一小区（1）中的第二小区段（CS2）中的至少一个用户（UE3）设备分配第一时隙。 然后，天线系统（Rx，Tx）同时向基站（BS）发送分配给第一时隙的所有用户设备（UE1，UE3）的信息。
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公开(公告)号：US20070111745A1
公开(公告)日：2007-05-17
申请号：US10596730
申请日：2003-12-22
申请人： Roland Carlsson , Torbjorn Karlsson
发明人： Roland Carlsson , Torbjorn Karlsson
CPC分类号： H04W52/60 , H04W52/262 , H04W52/286 , H04W52/34 , H04W52/367
摘要： A transmitting unit comprising a first unit (CM_SCHDR) receiving scheduled first data (DATA2, DATA3) for transmission on at least a first channel, a power control unit (PWR_CTRL) for the first channel responsive to a respective closed loop power regulation signal (TCP_CMD), under which at least the transmit power rate of change is limited to a predetermined value per time unit, a packet data scheduler (HS_SCHDR) scheduling second data packets (DATA1), such as HSPDA data, for transmission on at least a second channel at an actual power level (P_H(t)), and a power amplifier (POWER_AMP) amplifying and outputting the scheduled first and second data, whereby the outputted first and second channels are subject to interference from one another, is shown. A possible power (P_POS(t)) is determined at a given instance as the maximum value of either the actual power (P_HS(t−1)) at a previous instance or the possible power determined at a previous instance (P_POS(t−1)), decreasing the maximum value by a predetermined value (d). Moreover, a permitted power (P_PERM(t)) at a given instance as the maximum value of either the actual power of a previous instance (P_HS(t−1)) added with the predetermined value (d) or the determined possible power (P_POS(t)). Finally, the scheduling is performed within these limits.
摘要翻译： 一种发送单元，包括接收用于在至少第一信道上传输的调度的第一数据（DATA2，DATA3）的第一单元（CM_SCHDR），用于响应于各自的闭环功率调节信号的第一通道的功率控制单元（PWR_CTRL） （TCP_CMD），至少将发送功率变化率限制在每个时间单位的预定值，分组数据调度器（HS_SCHDR）至少调度第二数据分组（DATA 1），例如HSDPA数据，用于至少传输 示出了实际功率电平（P_H（t））的第二信道和放大并输出调度的第一和第二数据的功率放大器（POWER_AMP），由此输出的第一和第二信道彼此受到干扰。 在给定情况下确定可能的功率（P_POS（t））作为先前情况下的实际功率（P_H（t-1））或先前实例确定的可能功率的最大值（P_POS（t- 1）），将最大值减小预定值（d）。 此外，在给定实例处的允许功率（P_PERM（t））作为加上预定值（d）的前一个实例（P_H（t-1））的实际功率的最大值或所确定的可能功率 P_POS（t））。 最后，在这些限制内进行调度。
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公开(公告)号：US06958213B2
公开(公告)日：2005-10-25
申请号：US09734801
申请日：2000-12-12
CPC分类号： C12N15/10 , C12N15/1027
摘要： The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing single stranded DNA constituting plus and minus strands of parent polynucleotide sequences; (b) digesting the single stranded polynucleotide sequences with a nuclease other than DNase I to generate populations of single stranded fragments; (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3′ and 5′ ends of at least one of the parent polynucleotides under annealing conditions; (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides.
摘要翻译： 本发明提供了从编码一种或多种蛋白质基序的母体单链多核苷酸序列产生多核苷酸序列或序列群的方法，其包括以下步骤：（a）提供构成母体多核苷酸序列的正负链的单链DNA; （b）用除DNA酶I以外的核酸酶消化单链多核苷酸序列以产生单链片段群; （c）将由正链产生的所述片段与由负链产生的片段接触，并任选地加入在退火条件下与至少一种母体多核苷酸的3'和5'末端退火的引物序列; （d）与由所述亲本多核苷酸编码的一种或多种蛋白质基序相比，扩增彼此退火的片段以产生编码一种或多种具有改变特征的蛋白质基序的至少一个多核苷酸序列。
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