发明授权
- 专利标题： Methods and compositions for impairing multiplication of HIV-1
- 专利标题（中）： 减少HIV-1增殖的方法和组合物
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申请号： US11353293申请日： 2006-02-13
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公开(公告)号： US07563437B2公开(公告)日： 2009-07-21
- 发明人: Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
- 申请人： Roland Carlsson , Elisabeth Sonesson , Yvonne Stenberg , Leif Strandberg , Gideon Goldstein
- 申请人地址： US NJ Short Hills
- 专利权人： Thymon, LLC
- 当前专利权人： Thymon, LLC
- 当前专利权人地址： US NJ Short Hills
- 代理机构： Howson & Howson LLP
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
A single isolated antibody or antibody fragment thereof binds to multiple variant sequences within an epitope of HIV-1 Tat protein displayed in multiple strains and subtypes of HIV-1. This “pan-epitope” antibody is useful in therapeutic and prophylactic compositions and treatments of HIV-1 infection, regardless of strain. This pan-epitope antibody is useful in assays for the detection of levels of HIV-1 based on a measurement of the amount of Tat protein in a biological sample.
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