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    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells
    2.
    发明授权
    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells 有权
    桑ula或内细胞群细胞的分化方法及其谱系缺陷胚胎干细胞的制备方法

    公开(公告)号：US08753884B2

    公开(公告)日：2014-06-17

    申请号：US12152779

    申请日：2008-05-16

    申请人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    发明人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N15/00

    CPC分类号： C12N5/16 ,  A61K35/12 ,  C12N5/0606 ,  C12N2510/00

    摘要： An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.

    摘要翻译： 一种改进的产生分化祖细胞的方法，包括从囊胚获得内细胞质量细胞并诱导内细胞大量细胞的分化以产生分化祖细胞。 可以转染分化的祖细胞，使得存在所需基因的添加，缺失或改变。 分化的祖细胞可用于细胞治疗和作为用于产生移植组织和器官的细胞的I来源。 还提供了产生谱系缺陷型人胚胎干细胞的方法。

    HEMANGIO COLONY FORMING CELLS AND NON-ENGRAFTING HEMANGIO CELLS
    6.
    发明申请
    HEMANGIO COLONY FORMING CELLS AND NON-ENGRAFTING HEMANGIO CELLS 有权
    HEMANGIO COLONY成形细胞和非恒定HEMANGIO细胞

    公开(公告)号：US20110064705A1

    公开(公告)日：2011-03-17

    申请号：US12991096

    申请日：2009-05-06

    申请人： Robert Lanza ,  Shi-Jiang Lu

    发明人： Robert Lanza ,  Shi-Jiang Lu

    IPC分类号： A61K35/12 ,  C12N5/071 ,  C40B50/06 ,  C12N5/078 ,  C40B40/02 ,  A61P37/06 ,  A61P9/10

    CPC分类号： C12N5/0647 ,  A61K35/12 ,  A61K35/28 ,  A61K35/44 ,  A61K38/13 ,  A61K45/06 ,  A61K2035/124 ,  A61N5/10 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/14 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2506/02 ,  C12N2506/45

    摘要： Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.

    摘要翻译： 公开了在体外产生和扩大人血管瘤集落形成细胞和非移植血管瘤细胞的方法以及扩增和使用这些细胞的方法。 该方法允许生产大量的血管瘤集落形成细胞，非移植血管瘤细胞以及衍生细胞，如造血细胞和内皮细胞。 通过所公开的方法获得的细胞可用于各种研究，临床和治疗应用。 人类非移植血管瘤细胞是与成血管细胞和人类血管瘤集落形成细胞相关但不同的新型祖细胞群。 本发明还提供包含血管瘤集落形成细胞，非移植血管瘤细胞或与其分化的细胞的组合物，制剂和溶液。 组合物，制剂和溶液包括冷冻保存的制剂和基本纯化的制剂，以及与可以移入骨髓的相关成血管细胞祖细胞类型组合配制的混合组合物。