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    Apparatus for testing blood/biomaterials/device interactions and characteristics
    3.
    发明授权
    Apparatus for testing blood/biomaterials/device interactions and characteristics 失效
    用于测试血液/生物材料/器件相互作用和特性的装置

    公开(公告)号：US5271898A

    公开(公告)日：1993-12-21

    申请号：US56450

    申请日：1993-05-03

    申请人： Michael F. Wolf ,  Paul V. Trescony ,  James R. Keogh

    发明人： Michael F. Wolf ,  Paul V. Trescony ,  James R. Keogh

    IPC分类号： G01N11/00 ,  G01N33/487 ,  G01N33/49

    CPC分类号： G01N11/00 ,  G01N33/49 ,  Y10T436/117497

    摘要： An apparatus designed to test blood, blood contacting biomaterials and devices such as materials and surface-modified materials; vascular grafts, stents, heart valves, catheters, leads, etc., for blood and material responses in vitro under physiological blood flow conditions. The apparatus consists of a stepper-motor driven circular disc(s), upon which a test vehicle, containing either the test materials, coating or device, is mounted. The test vehicle itself consists of a circular, closed-loop of polymer tubing containing a check valve.

    摘要翻译： 设计用于测试血液，血液接触生物材料和诸如材料和表面改性材料的装置的设备; 血管移植物，支架，心脏瓣膜，导管，引线等，用于在生理血流条件下的体外血液和物质反应。 该设备由步进电机驱动的圆盘组成，其上安装有测试材料，涂层或装置的测试车辆。 测试车辆本身由包含止回阀的聚合物管的圆形闭环组成。

    Method for attachment of biomolecules to medical devices surfaces
    6.
    发明授权
    Method for attachment of biomolecules to medical devices surfaces 失效
    将生物分子附着到医疗器械表面的方法

    公开(公告)号：US5925552A

    公开(公告)日：1999-07-20

    申请号：US67188

    申请日：1998-04-27

    申请人： James R. Keogh ,  Paul V. Trescony

    发明人： James R. Keogh ,  Paul V. Trescony

    IPC分类号： A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L31/08 ,  A61L31/10 ,  A61L33/00 ,  A61L33/12 ,  A61L33/18 ,  C12N11/00 ,  A61K38/43 ,  G01N33/543 ,  C07K17/00

    CPC分类号： A61L33/18 ,  A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0047 ,  A61L33/0082 ,  A61L33/12 ,  A61L33/128 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

    摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiety is combined with an amine forming agent to form an amine-functional biomolecule. The amine-functional biomolecule is combined with a medical device surface having a chemical moiety such as aldehyde, epoxide, isocyanate, 1,2-dicarbonyl, phosphate, sulphate or carboxylate to form a chemical bond immobilizing the biomolecule on the surface. The chemical bond may be combined with a reducing agent or a stabilizing agent. The aldehyde moiety may be formed by combining a periodate with a 2-aminoalcohol moiety or a 1,2-dihydroxy moiety. Alternatively, an amine-functional medical device surface is combined with a biomolecule having a chemical moiety that reacts with an amine moiety. In another embodiment, the amine-functional biomolecule is converted to a guanidino-functional biomolecule and is combined with a medical device surface having a chemical moiety that reacts with a guanidino moiety. Alternatively, an amine-functional medical device surface is converted to a guanidino-functional surface and is combined with a biomolecule having the chemical moiety. Biomolecules may be crosslinked by combining the amine-functional or guanidino-functional biomolecule with a biomolecule having a chemical moiety that forms a chemical bond with an amine moiety or a guanidino moiety.

    摘要翻译： 提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。 将具有未取代的酰胺部分的生物分子例如具有未取代的酰胺部分的糖蛋白与胺形成剂合并以形成胺官能的生物分子。 将胺官能的生物分子与具有化学部分的医疗装置表面结合，例如醛，环氧化物，异氰酸酯，1,2-二羰基，磷酸酯，硫酸酯或羧酸酯，以形成将生物分子固定在表面上的化学键。 化学键可以与还原剂或稳定剂组合。 醛部分可以通过将高碘酸酯与2-氨基醇部分或1,2-二羟基部分结合而形成。 或者，将胺官能医疗器械表面与具有与胺部分反应的化学部分的生物分子组合。 在另一个实施方案中，将胺官能的生物分子转化为胍基官能的生物分子，并与具有与胍基部分反应的化学部分的医疗装置表面组合。 或者，将胺官能医疗器械表面转化为胍基官能表面，并与具有化学部分的生物分子组合。 生物分子可以通过将胺官能或胍基官能的生物分子与具有与胺部分或胍基部分形成化学键的化学部分的生物分子结合而交联。

    Vascular prosthesis and method
    8.
    发明授权
    Vascular prosthesis and method 失效
    血管假体和方法

    公开(公告)号：US5246451A

    公开(公告)日：1993-09-21

    申请号：US693753

    申请日：1991-04-30

    申请人： Paul V. Trescony ,  Patrick Cahalan ,  Kenneth Keeney

    发明人： Paul V. Trescony ,  Patrick Cahalan ,  Kenneth Keeney

    IPC分类号： A61F2/06 ,  A61L27/34 ,  A61L27/50 ,  A61L33/00

    CPC分类号： A61L33/0076 ,  A61F2/06 ,  A61L27/34 ,  A61L27/507 ,  Y10S623/921

    摘要： A vascular graft with improved endothelial cell adhesion can be achieved on a fluoropolymer surface of a vascular graft by treating the fluoropolymer with a plasma in the presence of a non-polymerizing gas capable of providing the fluoropolymer with anionic groups and binding a protein to the treated fluoropolymer. In a preferred embodiment, the fluoropolymer surface is a plasma deposited fluoropolymer. Also in a preferred embodiment, autologous endothelial cells are seeded onto the vascular graft prior to implantation of the vascular graft in the human body.

    摘要翻译： 可以在血管移植物的含氟聚合物表面上实现具有改善的内皮细胞粘附的血管移植物，其通过在能够提供含氟聚合物阴离子基团并将蛋白质与经处理的蛋白质结合的非聚合气体存在下用等离子体处理 含氟聚合物。 在优选的实施方案中，含氟聚合物表面是等离子体沉积的含氟聚合物。 同样在优选的实施方案中，在将血管移植物植入人体内之前，将自体内皮细胞接种到血管移植物上。

    Seeding implantable medical devices with cells
    9.
    发明授权
    Seeding implantable medical devices with cells 失效
    种植植入式医疗器械与细胞

    公开(公告)号：US07759120B2

    公开(公告)日：2010-07-20

    申请号：US11515344

    申请日：2006-09-01

    申请人： Michael F. Wolf ,  Laurie A. Yunker ,  Paul V. Trescony

    发明人： Michael F. Wolf ,  Laurie A. Yunker ,  Paul V. Trescony

    IPC分类号： C12N11/08

    CPC分类号： A61F2/062 ,  A61L27/16 ,  A61L27/3616 ,  A61L27/38 ,  A61L27/3808 ,  A61L27/507 ,  Y10S623/915 ,  Y10S623/916 ,  C08L27/18

    摘要： Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

    摘要翻译： 描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。 本发明支持用轴向离心法将装置的腔表面接种的技术。 将细胞悬浮液引入装置的内腔。 在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。 导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。 轴向离心导致细胞浓缩并附着在管腔表面。 在轴向离心后不久，可以将接种的装置用于植入患者体内。 可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

    CEREBROSPINAL FLUID SHUNT HAVING LONG TERM ANTI-OCCLUSION AGENT DELIVERY
    10.
    发明申请
    CEREBROSPINAL FLUID SHUNT HAVING LONG TERM ANTI-OCCLUSION AGENT DELIVERY 审中-公开
    具有长期抗肿瘤药物递送的脑脊液

    公开(公告)号：US20080082036A1

    公开(公告)日：2008-04-03

    申请号：US11380157

    申请日：2006-04-25

    申请人： Paul V. Trescony ,  Edouard Koullick

    发明人： Paul V. Trescony ,  Edouard Koullick

    IPC分类号： A61F2/20 ,  A61M1/00

    CPC分类号： A61M27/006 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61M25/007 ,  A61M2025/0019

    摘要： The invention includes a shunt for at least partial implantation into a patient that includes an elongated conduit having at least one lumen therethrough, that includes a proximal end for receipt of bodily fluids for flow through the shunt and a distal end for discharge of the bodily fluids from the shunt, and a long term source of at least one occlusion resistant agent, wherein said at least a portion of the at least one occlusion resistant agent can permeate through at least a portion of the elongated conduit. The invention also includes kits and systems.

    摘要翻译： 本发明包括用于至少部分植入患者的分流器，其包括具有至少一个通过其中的腔的细长管道，其包括用于接收流体通过分路的体液的近端和用于排出体液的远端 来自所述分路器以及长期来源的至少一种阻塞剂，其中所述至少一种抗阻塞剂的所述至少一部分可以渗透通过所述细长导管的至少一部分。 本发明还包括套件和系统。