公开(公告)号：US20090276048A1

公开(公告)日：2009-11-05

申请号：US12463262

申请日：2009-05-08

Applicant: Paul E. Chirico ,  Benny M. Chan ,  Jeffrey J. Christian

Inventor： Paul E. Chirico ,  Benny M. Chan ,  Jeffrey J. Christian

IPC: A61F2/44

CPC classification number: A61B17/025 ,  A61B17/68 ,  A61B17/8685 ,  A61B17/8811 ,  A61B17/8819 ,  A61B17/8858 ,  A61B2017/0046 ,  A61B2017/00469 ,  A61B2017/00867 ,  A61B2017/0256

Abstract: Described herein are devices and systems for restoring compression fractured vertebral bodies to a decompressed configuration and methods of restoring compression fractures by bilateral implantation of such devices.

Abstract translation: 这里描述的是用于将压缩的骨折椎体恢复到减压构型的装置和系统，以及通过这种装置的双侧植入来恢复压缩性骨折的方法。

公开(公告)号：US20090012564A1

公开(公告)日：2009-01-08

申请号：US12044884

申请日：2008-03-07

Applicant: Paul E. Chirico ,  Benny M. Chan ,  R. Sean Pakbaz ,  Joseph A. Horton ,  Alison M. Souza ,  Brian E. Martini

Inventor： Paul E. Chirico ,  Benny M. Chan ,  R. Sean Pakbaz ,  Joseph A. Horton ,  Alison M. Souza ,  Brian E. Martini

IPC: A61B17/70 ,  A61B19/00 ,  A61B17/04 ,  A61F11/00

CPC classification number: A61B17/1671 ,  A61B17/70 ,  A61B17/7098 ,  A61B17/7258 ,  A61B17/8858 ,  A61B2017/00867

Abstract: Described herein are devices and systems for transdiscal fusion of vertebrae and methods for fusing adjacent vertebra. A system may include a device with two anchorable members connectable by an intervening connector forming a continuous passageway therethrough. An anchorable member may have a constrained non-anchoring configuration and a released anchoring configuration. The anchoring configuration typically includes a radially-expanded structure such as a plurality of struts. After positioning the anchorable members into two adjacent vertebral bodies, the anchorable members may be released from their constrained configuration so that they radially self-expand, anchoring the device across the fracture. A flowable bone-filling material may be conveyed into the passageway of the device after implantation, stabilizing it further in the vertebral implantation site.

Abstract translation: 本文描述了用于椎间盘椎间融合的装置和系统以及用于融合相邻椎骨的方法。 系统可以包括具有两个可固定构件的装置，该可固定构件可通过中间连接器连接，形成通过其的连续通道。 可锚定构件可以具有约束的非锚定构型和释放的锚定构型。 锚定构造通常包括径向扩展的结构，例如多个支柱。 在将可固定构件定位到两个相邻的椎骨体中之后，可锚固构件可以从其约束构造释放，使得它们径向自扩张，将装置锚定在骨折上。 可流动的骨填充材料可在植入后输送到装置的通道中，并进一步在脊椎植入部位中稳定。

公开(公告)号：US20180093013A1

公开(公告)日：2018-04-05

申请号：US15820393

申请日：2017-11-21

Applicant: Houdin DEHNAD ,  Paul E. CHIRICO ,  Bohdan Wolodymyr CHOPKO ,  John BARR ,  Robert Vincent MC CORMICK ,  Julie LUCERO ,  Jason A. JEGGE

Inventor： Houdin DEHNAD ,  Paul E. CHIRICO ,  Bohdan Wolodymyr CHOPKO ,  John BARR ,  Robert Vincent MC CORMICK ,  Julie LUCERO ,  Jason A. JEGGE

IPC: A61L27/18 ,  A61L31/14 ,  A61L27/30 ,  A61L31/16 ,  A61L31/08 ,  A61L31/06 ,  A61L27/58 ,  A61L27/54 ,  C08L67/04

CPC classification number: A61L27/18 ,  A01N25/34 ,  A61K33/24 ,  A61K33/30 ,  A61K33/38 ,  A61L27/306 ,  A61L27/54 ,  A61L27/58 ,  A61L29/106 ,  A61L29/16 ,  A61L31/06 ,  A61L31/088 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  A61L2420/06 ,  C08L67/04 ,  A01N59/16 ,  A01N59/20 ,  A61K2300/00

Abstract: Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.

公开(公告)号：US20160157907A1

公开(公告)日：2016-06-09

申请号：US15012803

申请日：2016-02-01

Applicant: Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO

Inventor： Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO

IPC: A61B17/86 ,  A61L31/08 ,  A61L31/02 ,  A61L31/16

CPC classification number: A61B17/866 ,  A61B17/56 ,  A61B2017/00893 ,  A61B2017/561 ,  A61F2002/30677 ,  A61F2310/00113 ,  A61L31/022 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2400/16 ,  A61M25/0084

Abstract: Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.

Abstract translation: 本文描述了用于通过延长的时间段从植入物释放银来治疗疾病和/或感染的装置，系统和方法。 特别地，本文所述的装置可用于通过从延长使用的植入物的多个位点控制释放银离子来治疗诸如骨髓炎的感染。 这种植入物通常包括多个臂，锚固和帮助分布组织内释放的离子。 可以施加功率以将银离子释放到组织中。

公开(公告)号：US09248254B2

公开(公告)日：2016-02-02

申请号：US13527389

申请日：2012-06-19

Applicant: Houdin Dehnad ,  Bohdan Wolodymyr Chopko ,  Paul E. Chirico

Inventor： Houdin Dehnad ,  Bohdan Wolodymyr Chopko ,  Paul E. Chirico

IPC: A61B17/86 ,  A61M25/00 ,  A61B17/56 ,  A61B17/00 ,  A61F2/30

CPC classification number: A61B17/866 ,  A61B17/56 ,  A61B2017/00893 ,  A61B2017/561 ,  A61F2002/30677 ,  A61F2310/00113 ,  A61L31/022 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/602 ,  A61L2400/16 ,  A61M25/0084

Abstract: Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.

Abstract translation: 本文描述了用于通过延长的时间段从植入物释放银来治疗疾病和/或感染的装置，系统和方法。 特别地，本文所述的装置可用于通过从延长使用的植入物的多个位点控制释放银离子来治疗诸如骨髓炎的感染。 这种植入物通常包括多个臂，锚固和帮助分布组织内释放的离子。 可以施加功率以将银离子释放到组织中。

公开(公告)号：US20140288607A1

公开(公告)日：2014-09-25

申请号：US14300696

申请日：2014-06-10

Applicant: Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO ,  Robert Vincent MC CORMICK

Inventor： Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO ,  Robert Vincent MC CORMICK

IPC: A61B17/86

CPC classification number: A61M37/00 ,  A61B17/686 ,  A61B17/7266 ,  A61B17/80 ,  A61B17/8625 ,  A61B17/863 ,  A61B17/864 ,  A61B17/8685 ,  A61B17/869 ,  A61B2017/00889 ,  A61B2017/561 ,  A61C8/0012 ,  A61C8/0018 ,  A61C19/06 ,  A61F2/28 ,  A61K33/30 ,  A61K33/38 ,  A61N1/306

Abstract: Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.

Abstract translation: 描述银和/或锌离子释放植入物，操作，插入和激活/灭活它们的系统和方法。 在一些变型中，植入物被构造为骨植入物，其包括骨螺钉或髓内杆状体，其构造成接收治疗盒，所述治疗盒具有构造为阳极的多个离子释放构件，所述离子释放构件可控制地与导管接合以使电流 根据需要释放离子开/关。 这些装置可以被配置为将预定时间段以上的银离子（和/或锌离子）释放到预定水平上，并且可以将离子浓度保持在较大体积的组织上。 离子释放构件可以被配置为减少或防止植入物移动。

公开(公告)号：US20160136335A1

公开(公告)日：2016-05-19

申请号：US14806554

申请日：2015-07-22

Applicant: Houdin DEHNAD ,  Julie LUCERO ,  Paul E. CHIRICO ,  Jason A. JEGGE ,  Thomas Lee GUTSHALL

Inventor： Houdin DEHNAD ,  Julie LUCERO ,  Paul E. CHIRICO ,  Jason A. JEGGE ,  Thomas Lee GUTSHALL

IPC: A61L31/08 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  B05D3/04

CPC classification number: A61L31/088 ,  A61L27/306 ,  A61L27/54 ,  A61L27/58 ,  A61L29/106 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2300/80 ,  A61L2420/02 ,  A61L2420/06 ,  B05D3/0453

Abstract: Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate (including, but not limited to absorbable/resorbable substrates) so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.

Abstract translation: 抗微生物金属离子涂层。 特别地，本文所描述的是包括与阴极金属（例如钯，铂，金，钼，钛，铱，锇，锇等）共沉积的阳极金属（例如银和/或锌和/或铜） 铌或铼）在基底（包括但不限于可吸收/可再吸收的基底）上，使得当该装置暴露于体液时，阳极金属作为抗微生物离子被电流释放。 阳极金属可以是至少约25体积％的涂层，导致在阴极金属完全包封的涂层中阳极金属的网络小于阳极金属的20％。

公开(公告)号：US20130144204A1

公开(公告)日：2013-06-06

申请号：US13748546

申请日：2013-01-23

Applicant: Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO ,  Robert Vincent MC CORMICK

Inventor： Houdin DEHNAD ,  Bohdan Wolodymyr CHOPKO ,  Paul E. CHIRICO ,  Robert Vincent MC CORMICK

IPC: A61N1/30

CPC classification number: A61M37/00 ,  A61B17/686 ,  A61B17/7266 ,  A61B17/80 ,  A61B17/8625 ,  A61B17/863 ,  A61B17/864 ,  A61B17/8685 ,  A61B17/869 ,  A61B2017/00889 ,  A61B2017/561 ,  A61C8/0012 ,  A61C8/0018 ,  A61C19/06 ,  A61F2/28 ,  A61K33/30 ,  A61K33/38 ,  A61N1/306

Abstract: Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.

公开(公告)号：US20120123485A1

公开(公告)日：2012-05-17

申请号：US13231219

申请日：2011-09-13

Applicant: Houdin Dehnad ,  Bohdan Wolodymyr Chopko ,  Paul E. Chirico ,  Robert Vincent Mc Cormick

Inventor： Houdin Dehnad ,  Bohdan Wolodymyr Chopko ,  Paul E. Chirico ,  Robert Vincent Mc Cormick

IPC: A61B17/86

CPC classification number: A61M37/00 ,  A61B17/686 ,  A61B17/7266 ,  A61B17/80 ,  A61B17/8625 ,  A61B17/863 ,  A61B17/864 ,  A61B17/8685 ,  A61B17/869 ,  A61B2017/00889 ,  A61B2017/561 ,  A61C8/0012 ,  A61C8/0018 ,  A61C19/06 ,  A61F2/28 ,  A61K33/30 ,  A61K33/38 ,  A61N1/306

Abstract: Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.

Abstract translation: 描述银和/或锌离子释放植入物，操作，插入和激活/灭活它们的系统和方法。 在一些变型中，植入物被构造为骨植入物，其包括骨螺钉或髓内杆状体，其构造成接收治疗盒，所述治疗盒具有构造为阳极的多个离子释放构件，所述离子释放构件可控制地与导管接合以使电流 根据需要释放离子开/关。 这些装置可以被配置为将预定时间段以上的银离子（和/或锌离子）释放到预定水平上，并且可以将离子浓度保持在较大体积的组织上。 离子释放构件可以被配置为减少或防止植入物移动。

公开(公告)号：US20090234398A1

公开(公告)日：2009-09-17

申请号：US12473175

申请日：2009-05-27

Applicant: Paul E. Chirico ,  Ben M. Chan

Inventor： Paul E. Chirico ,  Ben M. Chan

IPC: A61F3/00 ,  A61F2/44 ,  A61B17/00

CPC classification number: A61B17/8858 ,  A61B17/1671 ,  A61B17/70 ,  A61B17/8855

Abstract: An expandable stabilization device is disclosed that is suitable for deployment within cancellous bone, including, for example, within a vertebral body of a spine. The device comprises: an elongate expandable shaft adapted to be positioned within a vertebral body having a first profile and a second profile; wherein the shaft is adapted to cut through cancellous bone within the vertebral body during expansion from the first profile to the second profile; and further wherein the shaft is adapted to abut a surface of cortical bone within the vertebral body without passing therethrough. The invention also includes a method for treating cancellous bone, such as cancellous bone of a vertebral body. The method comprises: delivering an expandable device within the cancellous bone of in an interior of a vertebral body; expanding the delivered device within the cancellous bone of the vertebra body; applying force from a surface of the device to an inner surface of a cancellous bone of the vertebral body sufficient to cut through the cancellous bone; and applying force from a surface of the device to an inner surface of a cortical bone of the vertebral body sufficient to support the vertebral body.

Abstract translation: 公开了一种可膨胀的稳定装置，其适于在松质骨内展开，包括例如脊椎的椎体内。 所述装置包括：细长可扩张轴，其适于定位在具有第一轮廓和第二轮廓的椎骨体内; 其中所述轴适于在从所述第一轮廓到所述第二轮廓的膨胀期间切割所述椎骨体内的松质骨; 并且进一步其中所述轴适于邻接所述脊椎体内皮质骨的表面，而不通过所述皮质骨。 本发明还包括一种治疗松质骨的方法，例如椎体的松质骨。 该方法包括：在椎骨内部的松质骨内输送可扩张装置; 扩大椎体内松质骨内的输送装置; 从装置的表面施加力到椎骨的松质骨的内表面足以穿过松质骨; 以及将力从所述装置的表面施加到所述椎体的皮质骨的内表面，足以支撑所述椎体。