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1.发明申请公开(公告)号：US20180093013A1
公开(公告)日：2018-04-05
申请号：US15820393
申请日：2017-11-21
申请人： Houdin DEHNAD , Paul E. CHIRICO , Bohdan Wolodymyr CHOPKO , John BARR , Robert Vincent MC CORMICK , Julie LUCERO , Jason A. JEGGE
发明人： Houdin DEHNAD , Paul E. CHIRICO , Bohdan Wolodymyr CHOPKO , John BARR , Robert Vincent MC CORMICK , Julie LUCERO , Jason A. JEGGE
IPC分类号： A61L27/18 , A61L31/14 , A61L27/30 , A61L31/16 , A61L31/08 , A61L31/06 , A61L27/58 , A61L27/54 , C08L67/04
CPC分类号： A61L27/18 , A01N25/34 , A61K33/24 , A61K33/30 , A61K33/38 , A61L27/306 , A61L27/54 , A61L27/58 , A61L29/106 , A61L29/16 , A61L31/06 , A61L31/088 , A61L31/148 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/604 , A61L2300/606 , A61L2400/18 , A61L2420/06 , C08L67/04 , A01N59/16 , A01N59/20 , A61K2300/00
摘要： Antimicrobial metal ion coatings and implants including them. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, rhodium, manganese, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal. The implant may be configured as an implant such as a bone-screw or intramedullary rod-like body configured to receive a treatment cartridge having a coating as described.
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公开(公告)号：US20150359946A1
公开(公告)日：2015-12-17
申请号：US14833569
申请日：2015-08-24
申请人： Houdin DEHNAD , Paul E. CHIRICO , Bohdan Wolodymyr CHOPKO , John BARR , Robert Vincent MC CORMICK , Julie LUCERO , Jason A. JEGGE
发明人： Houdin DEHNAD , Paul E. CHIRICO , Bohdan Wolodymyr CHOPKO , John BARR , Robert Vincent MC CORMICK , Julie LUCERO , Jason A. JEGGE
CPC分类号： A61L31/16 , A01N25/34 , A61K33/24 , A61K33/30 , A61K33/38 , A61L27/18 , A61L27/306 , A61L27/54 , A61L27/58 , A61L29/106 , A61L29/16 , A61L31/06 , A61L31/088 , A61L31/148 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/604 , C08L67/04 , A01N59/16 , A01N59/20 , A61K2300/00
摘要： Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.
摘要翻译： 抗微生物金属离子涂层。 特别地，本文所描述的是包括与阴极金属（例如钯，铂，金，钼，钛，铱，锇，锇等）共沉积的阳极金属（例如银和/或锌和/或铜） 铌或铼），使得当设备暴露于体液时，阳极金属作为抗微生物离子被电流释放。 阳极金属可以是至少约25体积％的涂层，导致在阴极金属完全包封的涂层中阳极金属的网络小于阳极金属的20％。
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公开(公告)号：US20130144204A1
公开(公告)日：2013-06-06
申请号：US13748546
申请日：2013-01-23
IPC分类号： A61N1/30
CPC分类号： A61M37/00 , A61B17/686 , A61B17/7266 , A61B17/80 , A61B17/8625 , A61B17/863 , A61B17/864 , A61B17/8685 , A61B17/869 , A61B2017/00889 , A61B2017/561 , A61C8/0012 , A61C8/0018 , A61C19/06 , A61F2/28 , A61K33/30 , A61K33/38 , A61N1/306
摘要： Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.
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公开(公告)号：US20140288607A1
公开(公告)日：2014-09-25
申请号：US14300696
申请日：2014-06-10
IPC分类号： A61B17/86
CPC分类号： A61M37/00 , A61B17/686 , A61B17/7266 , A61B17/80 , A61B17/8625 , A61B17/863 , A61B17/864 , A61B17/8685 , A61B17/869 , A61B2017/00889 , A61B2017/561 , A61C8/0012 , A61C8/0018 , A61C19/06 , A61F2/28 , A61K33/30 , A61K33/38 , A61N1/306
摘要： Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.
摘要翻译： 描述银和/或锌离子释放植入物，操作，插入和激活/灭活它们的系统和方法。 在一些变型中，植入物被构造为骨植入物，其包括骨螺钉或髓内杆状体，其构造成接收治疗盒，所述治疗盒具有构造为阳极的多个离子释放构件，所述离子释放构件可控制地与导管接合以使电流 根据需要释放离子开/关。 这些装置可以被配置为将预定时间段以上的银离子（和/或锌离子）释放到预定水平上，并且可以将离子浓度保持在较大体积的组织上。 离子释放构件可以被配置为减少或防止植入物移动。
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公开(公告)号：US20170014607A9
公开(公告)日：2017-01-19
申请号：US14801732
申请日：2015-07-16
CPC分类号： A61M37/00 , A61B17/686 , A61B17/7266 , A61B17/80 , A61B17/8625 , A61B17/863 , A61B17/864 , A61B17/8685 , A61B17/869 , A61B2017/00889 , A61B2017/561 , A61C8/0012 , A61C8/0018 , A61C19/06 , A61F2/28 , A61K33/30 , A61K33/38 , A61N1/306
摘要： Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.
摘要翻译： 描述银和/或锌离子释放植入物，操作，插入和激活/灭活它们的系统和方法。 在一些变型中，植入物被构造为骨植入物，其包括骨螺钉或髓内杆状体，其构造成接收治疗盒，所述治疗盒具有构造为阳极的多个离子释放构件，所述离子释放构件可控制地与导管接合以使电流 根据需要释放离子开/关。 这些装置可以被配置为将预定时间段以上的银离子（和/或锌离子）释放到预定水平上，并且可以将离子浓度保持在较大体积的组织上。 离子释放构件可以被配置为减少或防止植入物移动。
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公开(公告)号：US20150320989A1
公开(公告)日：2015-11-12
申请号：US14801732
申请日：2015-07-16
CPC分类号： A61M37/00 , A61B17/686 , A61B17/7266 , A61B17/80 , A61B17/8625 , A61B17/863 , A61B17/864 , A61B17/8685 , A61B17/869 , A61B2017/00889 , A61B2017/561 , A61C8/0012 , A61C8/0018 , A61C19/06 , A61F2/28 , A61K33/30 , A61K33/38 , A61N1/306
摘要： Silver and/or zinc ion releasing implants, systems and method of operating, inserting and activating/inactivating them are described. In some variations the implant is configured as a bone implant that includes a bone-screw or intramedullary rod like body configured to receive a treatment cartridge having a plurality of ion-releasing members configured as an anode that can controllably engage with a catheter to turn galvanic release of ions on/off as desired. These devices may be configured to release silver ions (and/or zinc ions) above a predetermined level for a predetermined period of time and may maintain a concentration of ions over a relatively large volume of tissue. The ion-releasing members may be configured to reduce or prevent implant movement.
摘要翻译： 描述银和/或锌离子释放植入物，操作，插入和激活/灭活它们的系统和方法。 在一些变型中，植入物被构造为骨植入物，其包括骨螺钉或髓内杆状体，其构造成接收治疗盒，所述治疗盒具有构造为阳极的多个离子释放构件，所述离子释放构件可控制地与导管接合以使电流 根据需要释放离子开/关。 这些装置可以被配置为将预定时间段以上的银离子（和/或锌离子）释放到预定水平上，并且可以将离子浓度保持在较大体积的组织上。 离子释放构件可以被配置为减少或防止植入物移动。
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公开(公告)号：US20160157907A1
公开(公告)日：2016-06-09
申请号：US15012803
申请日：2016-02-01
CPC分类号： A61B17/866 , A61B17/56 , A61B2017/00893 , A61B2017/561 , A61F2002/30677 , A61F2310/00113 , A61L31/022 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2400/16 , A61M25/0084
摘要： Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.
摘要翻译： 本文描述了用于通过延长的时间段从植入物释放银来治疗疾病和/或感染的装置，系统和方法。 特别地，本文所述的装置可用于通过从延长使用的植入物的多个位点控制释放银离子来治疗诸如骨髓炎的感染。 这种植入物通常包括多个臂，锚固和帮助分布组织内释放的离子。 可以施加功率以将银离子释放到组织中。
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公开(公告)号：US20180296262A1
公开(公告)日：2018-10-18
申请号：US16015085
申请日：2018-06-21
IPC分类号： A61B17/86 , A61M25/00 , A61L31/16 , A61L31/02 , A61L31/08 , A61B17/56 , A61F2/30 , A61B17/00
CPC分类号： A61B17/866 , A61B17/56 , A61B2017/00893 , A61B2017/561 , A61F2002/30677 , A61F2310/00113 , A61L31/022 , A61L31/088 , A61L31/16 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2400/16 , A61M25/0084
摘要： Described herein are devices, systems and methods for treating disease and/or infection by the release of silver from an implant over an extended period of time. In particular, the devices described herein may be used to treat infections such as osteomyelitis by the controlled release of silver ions from multiple sites of an extended-use implant. This implant typically includes a plurality of arms that both anchor and help distribute the released ions within the tissue. Power may be applied to release the silver ions into the tissue.
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