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    Compositions that specifically bind to colorectal cancer cells and methods of using the same
    1.
    发明授权
    Compositions that specifically bind to colorectal cancer cells and methods of using the same 有权
    特异性结合结肠直肠癌细胞的组合物及其使用方法

    公开(公告)号：US07135333B1

    公开(公告)日：2006-11-14

    申请号：US09649697

    申请日：2000-08-28

    申请人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    发明人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    IPC分类号： C12N5/10

    CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  G01N33/57419

    摘要： A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed as are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.

    摘要翻译： 公开了一种独特的转录产物CRCA-1和由其产生的替代的翻译产物。 转录物及其翻译产物是结肠直肠细胞的标志物。 公开了用于转移性结直肠癌的筛选和诊断试剂，试剂盒和方法，作为用于鉴定起源于结肠直肠的腺癌的试剂，试剂盒和方法。 公开了治疗转移性结肠直肠癌患者和体内成像转移性结肠直肠肿瘤的化合物，组合物和方法。 公开了将结合活性化合物如基因治疗剂和反义化合物递送至结肠直肠细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌的疫苗组合物和方法。

    Methods of identifying and detecting pancreatic cancer
    3.
    发明授权
    Methods of identifying and detecting pancreatic cancer 失效
    识别和检测胰腺癌的方法

    公开(公告)号：US06187536B1

    公开(公告)日：2001-02-13

    申请号：US09025534

    申请日：1998-02-18

    申请人： David Weinberg ,  Scott A. Waldman ,  Michael T. Barber ,  Sanjoy Biswas

    发明人： David Weinberg ,  Scott A. Waldman ,  Michael T. Barber ,  Sanjoy Biswas

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6886 ,  A61K47/62 ,  C12Q2600/112 ,  C12Q2600/136

    摘要： Conjugated compounds which comprises an CCK A receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an CCK A receptor binding moiety and a radiostable active moiety or an CCK A receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from pancreatic cancer are disclosed. Methods of radioimaging pancreatic cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has pancreatic cancer cells, for determining whether tumor cells are pancreatic in origin and for analyzing tissue samples to evaluate the extent of metastasis of pancreatic tumor cells.

    摘要翻译： 公开了包含CCK A受体结合部分和无定型活性部分的共轭化合物。 公开了包含CCK A受体结合部分和无稳定活性部分或CCK A受体结合部分和放射性活性部分的共轭化合物的药物组合物。 公开了治疗怀疑患有胰腺癌的个体的方法。 公开了放射成像胰腺癌细胞的方法。 公开了用于确定个体是否具有胰腺癌细胞的体外方法，试剂盒和试剂，用于确定肿瘤细胞是否在胰腺中起源，并用于分析组织样品以评估胰腺肿瘤细胞的转移程度。

    Compositions that specifically bind to colorectal cancer cells and methods of using the same
    5.
    发明授权
    Compositions that specifically bind to colorectal cancer cells and methods of using the same 失效
    特异性结合结肠直肠癌细胞的组合物及其使用方法

    公开(公告)号：US07316902B2

    公开(公告)日：2008-01-08

    申请号：US10656895

    申请日：2003-09-05

    申请人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    发明人： Scott A. Waldman ,  Joshua M. Pearlman ,  Michael T. Barber ,  Stephanie Schulz ,  Scott J. Parkinson

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/705 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  G01N33/57419

    摘要： A unique transcription product, CRCA-1, and alternative translation products generated therefrom, are disclosed. The transcript and its translation products are markers for colorectal cells. Screening and diagnostic reagents, kits and methods for metastasized colorectal cancer are disclosed ars are reagents, kits and methods for identifying adenocarcinomas as colorectal in origin. Compounds, compositions and methods of treating patients with metastasized colorectal cancer and for imaging metastasized colorectal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as gene therapeutics and antisense compounds to colorectal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastasized colorectal cancer are disclosed.

    摘要翻译： 公开了一种独特的转录产物CRCA-1和由其产生的替代的翻译产物。 转录物及其翻译产物是结肠直肠细胞的标志物。 公开了用于转移性结肠直肠癌的筛选和诊断试剂，试剂盒和方法，ar是用于鉴定起源于结肠直肠的腺癌的试剂，试剂盒和方法。 公开了治疗转移性结肠直肠癌患者和体内成像转移性结肠直肠肿瘤的化合物，组合物和方法。 公开了将结合活性化合物如基因治疗剂和反义化合物递送至结肠直肠细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌的疫苗组合物和方法。

    Adjustable rubber band
    7.
    发明授权
    Adjustable rubber band 失效
    可调橡胶带

    公开(公告)号：US4689858A

    公开(公告)日：1987-09-01

    申请号：US873728

    申请日：1986-06-12

    申请人： Michael T. Barber

    发明人： Michael T. Barber

    IPC分类号： A44B11/04 ,  B65D63/14 ,  B65D63/00

    CPC分类号： B65D63/14 ,  A44B11/04 ,  Y10T24/1408 ,  Y10T24/44983 ,  Y10T24/4736

    摘要： A fastening device comprised of an elastic band permanently attached at one end either in a utilitarian sense or in a static sense and temporarily attached at the other end, of which is adjustable by pulling on this unattached end, to a simple clasp with holes of a similar diameter as the elastic band and of which secures the band to a specific total circumference and range of tensile strength by the force of friction generated between the band and clasp.

    摘要翻译： 紧固装置由弹性带构成，其一端在功能意义上或静止意义上永久地附接，并且在另一端临时附接，其可通过将该未连接的端部拉动而调节到具有孔的简单的扣环 与弹性带相似的直径，并且通过在带和扣之间产生的摩擦力将带固定到特定的总圆周和拉伸强度的范围。