公开(公告)号：US07937228B2

公开(公告)日：2011-05-03

申请号：US12076516

申请日：2008-03-19

Applicant: Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

Inventor： Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US07648678B2

公开(公告)日：2010-01-19

申请号：US10731316

申请日：2003-12-08

Applicant: John Favuzzi ,  Benno Guggenheimer ,  Jeff Rau ,  Marc Key ,  Robert Lathrop ,  Rosanne Welcher

Inventor： John Favuzzi ,  Benno Guggenheimer ,  Jeff Rau ,  Marc Key ,  Robert Lathrop ,  Rosanne Welcher

IPC: G01N1/28 ,  G01N1/30

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

公开(公告)号：US20060046298A1

公开(公告)日：2006-03-02

申请号：US10539561

申请日：2003-12-19

Applicant: Marc Key ,  Gordon Feingold ,  Rosanne Welcher

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 通过输入173。 可以在系统正在处理初始聚合并且可变参数机器人控制模拟功能606时完成初始聚合事件拓扑的改变，以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US20140038232A1

公开(公告)日：2014-02-06

申请号：US14053977

申请日：2013-10-15

Applicant: Marc Key ,  Gordon Feingold ,  Rosanne Welcher

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N1/30

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据事件规定的所需聚合自动地处理样本 可以通过输入173.当系统正在处理初始聚合并且可变参数机器人控制时可以接受初始聚合事件拓扑的改变，可以实现功能606以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。

公开(公告)号：US08298815B2

公开(公告)日：2012-10-30

申请号：US10539562

申请日：2003-12-22

Applicant: Kristopher Buchanan ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher ,  Benno Guggenheimer ,  Robert Clark ,  Michael Barber ,  Bob Lathrop

Inventor： Kristopher Buchanan ,  Marc Key ,  John Favuzzi ,  Rosanne Welcher ,  Benno Guggenheimer ,  Robert Clark ,  Michael Barber ,  Bob Lathrop

IPC: C12M1/34 ,  C12M3/00 ,  C12M1/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

Abstract translation: 公开了样品处理和温度控制的系统和方法。 本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。 具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。 公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。 本发明可能具有特定适用性的科学领域包括免疫组织化学，原位杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和 生物应用。

公开(公告)号：US20080241876A1

公开(公告)日：2008-10-02

申请号：US12076516

申请日：2008-03-19

Applicant: Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

Inventor： Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

IPC: G01N1/30 ,  C12M1/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了一种可以是自动化的样品处理系统和方法，其中样品被布置在载体元件上，并且过程操作控制系统可以机器人地自动处理样品，其具有操作上有影响力的外部信息监视器或数据捕获元件。 可以监视重要的过程细节以及对操作有影响的外部信息的信息，并且自动通知单元可能导致人们在可能是远程的某些显示器处的通知。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US07400983B2

公开(公告)日：2008-07-15

申请号：US10538745

申请日：2003-12-19

Applicant: Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

Inventor： Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

IPC: G01N35/00 ,  G01N35/10

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system (101) that may be automated and methods are disclosed where samples) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the samples) perhaps robotically with an operationally-influential exteriorly-consequential information monitor (402) or a data capture element (414). Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element (404) may cause notification of a person at some display (415) that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了可以是自动化的样品处理系统（101）和方法，其中样品）（198）布置在载体元件（197）上，并且过程操作控制系统（171）可以机器人地自动处理样品， 有影响力的外部信息监视器（402）或数据捕获元件（414）。 可以监视重要的过程细节以及对操作有影响的外部后果信息，并且自动通知元件（404）可以引起人的通知，所述显示（415）可能是远程的。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US20060085140A1

公开(公告)日：2006-04-20

申请号：US10538745

申请日：2003-12-19

Applicant: Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

Inventor： Gordon Feingold ,  Marc Key ,  Rosanne Welcher ,  John Favuzzi

IPC: G06F19/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system (101) that may be automated and methods are disclosed where samples) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the samples) perhaps robotically with an operationally-influential exteriorly-consequential information monitor (402) or a data capture element (414). Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element (404) may cause notification of a person at some display (415) that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Abstract translation: 公开了可以是自动化的样品处理系统（101）和方法，其中样品）（198）布置在载体元件（197）上，并且过程操作控制系统（171）可以机器人地自动处理样品， 有影响力的外部信息监视器（402）或数据捕获元件（414）。 可以监视重要的过程细节以及对操作有影响的外部后果信息，并且自动通知元件（404）可以引起人的通知，所述显示（415）可能是远程的。 可以通知各种人员，例如管理员，供应商或具有诸如试剂重新排序等的某些动作的机会的制造商。 模拟运动显示可以包括在实际处理完成之后实时或长时间“监视”模拟操作。

公开(公告)号：US20060063265A1

公开(公告)日：2006-03-23

申请号：US10539035

申请日：2003-12-19

Applicant: Rosanne Welcher ,  Marc Key ,  Gorden Feingold ,  Doug Sweet ,  John Favuzzi

Inventor： Rosanne Welcher ,  Marc Key ,  Gorden Feingold ,  Doug Sweet ,  John Favuzzi

IPC: G01N35/00

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system (101) that may be automated and methods are disclosed where sample(s) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the sample(s) perhaps robotically with a sample process parameter input (173) that may be independent and an independent process parameter memory that does not interrupt process operation when being used. There may be an interspersial robotic control element responsive to an automatic data replication memory and to which a robotic motion system is responsive.

Abstract translation: 公开了可以是自动化的样本处理系统（101）和方法，其中样本（198）布置在载体元件（197）上，并且过程操作控制系统（171）可能机器人地自动处理样品 具有可以是独立的样本过程参数输入（173）和在使用时不中断处理操作的独立过程参数存储器。 可能存在响应于自动数据复制存储器并且机器人运动系统响应的跨人机器人控制元件。

公开(公告)号：US08969086B2

公开(公告)日：2015-03-03

申请号：US14182616

申请日：2014-02-18

Applicant: Marc Key ,  Gordon Feingold ,  Rosanne Welcher

Inventor： Marc Key ,  Gordon Feingold ,  Rosanne Welcher

IPC: G01N35/00 ,  G01N1/30 ,  G01N1/31

CPC classification number: G01N35/00732 ,  G01N1/30 ,  G01N1/31 ,  G01N1/312 ,  G01N35/00712 ,  G01N35/00871 ,  G01N35/0092 ,  G01N35/0099 ,  G01N2035/00039 ,  G01N2035/00089 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00366 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00881 ,  G01N2035/00891 ,  G16H50/20 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S901/02 ,  Y10S901/41 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/2575

Abstract: A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173. Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Abstract translation: 公开了可以是自动化的样本处理系统101和方法，其中样本198布置在载体元件197上，并且过程操作控制系统171可以根据期望的事件聚合事件自动地处理样本 可以通过输入173.当系统正在处理初始聚合并且可变参数机器人控制时可以接受初始聚合事件拓扑的改变，可以实现功能606以确定用于处理的增强的序列。 可以显示建议的操作者动作，其可以进一步增强改变的聚合事件拓扑的调度以及可以通知操作者需要特定动作以实现所需任务的自动操作者需求提示608。 提出的改变的可逆性可以提供，以便操作者可以避免在导致不可接受的处理结果时激活所提出的改变。