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公开(公告)号：US08784735B2
公开(公告)日：2014-07-22
申请号：US13964562
申请日：2013-08-12
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US08529836B2
公开(公告)日：2013-09-10
申请号：US13493969
申请日：2012-06-11
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US20120310422A1
公开(公告)日：2012-12-06
申请号：US13493969
申请日：2012-06-11
IPC分类号： G05D7/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US08298815B2
公开(公告)日：2012-10-30
申请号：US10539562
申请日：2003-12-22
申请人： Kristopher Buchanan , Marc Key , John Favuzzi , Rosanne Welcher , Benno Guggenheimer , Robert Clark , Michael Barber , Bob Lathrop
发明人： Kristopher Buchanan , Marc Key , John Favuzzi , Rosanne Welcher , Benno Guggenheimer , Robert Clark , Michael Barber , Bob Lathrop
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1), sample carrier temperature regulation systems (60), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.
摘要翻译： 公开了样品处理和温度控制的系统和方法。 本发明可以特别涉及温度控制，并且在一些实施例中可以是自动化样品处理系统的温度控制方法和自动样品处理方法。 具体地，本发明提供了与样品处理系统和处理样品的方法相关的温度控制，并且在一些实施例中提供了与样品载体和加工材料如试剂相关的温度控制。 公开了相应的系统和装置，包括样品处理系统（1），样品载体温度调节系统（60），试剂温度调节系统，样品处理控制系统和温度调节装置。 本发明可能具有特定适用性的科学领域包括免疫组织化学，原位杂交，荧光原位杂交，特殊染色，例如组织学样品的特殊染色，微阵列样品处理和细胞学，以及潜在的其它化学和 生物应用。
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公开(公告)号：US20130330252A1
公开(公告)日：2013-12-12
申请号：US13964562
申请日：2013-08-12
IPC分类号： G01N1/31
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译： 本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括： 一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。
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公开(公告)号：US07758809B2
公开(公告)日：2010-07-20
申请号：US12630665
申请日：2009-12-03
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译： 本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。 该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物 元素甚至浸渍槽。 通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。 载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。
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公开(公告)号：US20050064535A1
公开(公告)日：2005-03-24
申请号：US10731316
申请日：2003-12-08
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
IPC分类号： B01L3/02 , B32B5/02 , G01M1/38 , G01N1/10 , G01N1/30 , G01N1/31 , G01N15/06 , G01N35/00 , G01N35/02 , G05B21/00 , G01N33/48 , C12M1/34
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译： 本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。 该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物 元素甚至浸渍槽。 通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。 载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。
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8.发明授权Method for the calibration and alignment of multiple multi-axis motion stages for optical alignment to a planar waveguide device and system 失效用于光学对准到平面波导器件和系统的多个多轴运动级的校准和对准的方法公开(公告)号：US06809823B2
公开(公告)日：2004-10-26
申请号：US09967451
申请日：2001-09-28
申请人： William P Kennedy , John Bernard Medberry , David Washburn , Benno Guggenheimer , James D Adams
发明人： William P Kennedy , John Bernard Medberry , David Washburn , Benno Guggenheimer , James D Adams
IPC分类号： G01B1100
CPC分类号： G01B11/27
摘要： An optical system for detecting and coupling light to optical devices, and a method for aligning and calibrating the system. The system includes positioning stages and fiber sensors. The fiber sensors are used to detect the positions of calibration pieces and other sensors in a variety of configurations. From these detected positions, any misalignment of the sensors or positioning stages may be calculated and corrected for. The fiber sensors calibrate the system.
摘要翻译： 用于检测和耦合光到光学装置的光学系统，以及用于对准和校准系统的方法。 该系统包括定位台和光纤传感器。 光纤传感器用于检测各种配置中校准件和其他传感器的位置。 从这些检测到的位置，可以计算和校正传感器或定位台的任何未对准。 光纤传感器校准系统。
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公开(公告)号：US20100081167A1
公开(公告)日：2010-04-01
申请号：US12630665
申请日：2009-12-03
申请人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
发明人： John Favuzzi , Benno Guggenheimer , Jeff Rau , Marc Key , Robert Lathrop , Rosanne Welcher
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.
摘要翻译： 本发明涉及通过施加试剂自动染色容纳在载玻片上的至少一个组织样本的方法和装置。 该系统可以包括设置在滑架中的至少一个滑块，流体容纳元件，滑动夹持器，用于将滑块枢转到垂直位置的垂直滑动定位器，以及滑动式沉浸元件，以将垂直滑块浸入流体容纳物 元素甚至浸渍槽。 通过将幻灯片从水平方向枢转到垂直位置，可以提供用于在自动染色装置中进行预处理的自动化方法和装置。 载玻片的枢转可以确保用于预处理和染色过程的载玻片的适当取向。
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10.发明申请Method and apparatus for automated pre-treatment and processing of biological samples 有权用于生物样品自动预处理和处理的方法和装置公开(公告)号：US20060105359A1
公开(公告)日：2006-05-18
申请号：US11156760
申请日：2005-06-20
申请人： John Favuzzi , Kristopher Buchanan , Michael Barber , Loren Bland , Dawn Rohrbacker , Robert Clark , Gordon Feingold , Benno Guggenheimer , Marc Key , Merritt Martin , Robert Lathrop , Jeffery Rau , Jonathan Sweda , Douglas Sweet , John Van Bosch , Lars Winther , Rosanne Welcher
发明人： John Favuzzi , Kristopher Buchanan , Michael Barber , Loren Bland , Dawn Rohrbacker , Robert Clark , Gordon Feingold , Benno Guggenheimer , Marc Key , Merritt Martin , Robert Lathrop , Jeffery Rau , Jonathan Sweda , Douglas Sweet , John Van Bosch , Lars Winther , Rosanne Welcher
CPC分类号： G01N35/0092 , B01L3/508 , B01L7/00 , B01L9/06 , B01L2200/025 , B01L2200/16 , B01L2300/021 , B01L2300/0822 , B01L2300/1822 , G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0095 , G01N35/0099 , G01N35/1002 , G01N35/1004 , G01N35/1011 , G01N2035/00356 , G01N2035/00366 , G01N2035/00445 , G01N2035/00455 , G01N2035/00534 , G01N2035/00633 , G01N2035/00673 , G01N2035/00752 , G01N2035/00861 , G01N2035/00881 , G01N2035/102 , G01N2035/1058 , Y02A90/26 , Y10T436/11 , Y10T436/112499 , Y10T436/12 , Y10T436/2575
摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.
摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。
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