公开(公告)号：US20240408103A1

公开(公告)日：2024-12-12

申请号：US18699027

申请日：2022-09-28

Applicant: Medience Co., Ltd.

Inventor： Soo Hyun PARK ,  Set Byeol KIM ,  Jeong Hoon KIM ,  Young Won MO

IPC: A61K31/536 ,  A61K31/138 ,  A61K31/155 ,  A61P31/14 ,  A61P31/20

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating viral infectious diseases, containing efavirenz and fluoxetine as active ingredients. It has been identified that when a complex, mixture or combination of efavirenz and fluoxetine is administered or a complex, mixture or combination of efavirenz fluoxetine, to which a biguanide-based compound metformin is added, is administered, antiviral efficacy against various zoonotic viruses including SARS-CoV-2 is remarkably higher than when each is administered alone, and thus efavirenz and fluoxetine, in addition to the biguanide-based compound, can be effectively used as active ingredients of a composition for preventing or treating viral infectious diseases.

公开(公告)号：US11376295B2

公开(公告)日：2022-07-05

申请号：US16975981

申请日：2018-10-12

Applicant: MEDIENCE CO.,LTD

Inventor： Sang Jae Park ,  Kyoung Hee Kim

IPC: A61K36/22 ,  A23L33/115 ,  A61P35/04 ,  A61K31/353

Abstract: A method for preparing a Rhus verniciflua Stokes extract with an increased content of fisetin, the method including adding reacting at least one catalyst selected from the group consisting of platinum, chromium, nickel, silicon, copper, and oxides of these metals, to a Rhus verniciflua Stokes extract or a concentrated Rhus verniciflua Stokes extract and conducting reaction to convert fustin contained in the Rhus verniciflua Stokes into fisetin, and a functional health food composition for preventing or ameliorating cancer, or an anticancer pharmaceutical composition for inhibiting metastasis of cancer, as a main component, containing the Rhus verniciflua Stokes extract with an increased content of fisetin, prepared by the method which provides a very safe and efficient method that is capable of preparing an extract that exhibits improved antioxidant activity and anticancer activity by increasing the content of the main functional ingredients of natural extracts, and an anticancer agent composition.

公开(公告)号：US20210038667A1

公开(公告)日：2021-02-11

申请号：US16975981

申请日：2018-10-12

Applicant: MEDIENCE CO.,LTD

Inventor： Sang Jae PARK ,  Kyoung Hee KIM

IPC: A61K36/22 ,  A61K31/353 ,  A23L33/115 ,  A61P35/04

Abstract: A method for preparing a Rhus verniciflua Stokes extract with an increased content of fisetin, the method including adding reacting at least one catalyst selected from the group consisting of platinum, chromium, nickel, silicon, copper, and oxides of these metals, to a Rhus verniciflua Stokes extract or a concentrated Rhus verniciflua Stokes extract and conducting reaction to convert fustin contained in the Rhus verniciflua Stokes into fisetin, and a functional health food composition for preventing or ameliorating cancer, or an anticancer pharmaceutical composition for inhibiting metastasis of cancer, as a main component, containing the Rhus verniciflua Stokes extract with an increased content of fisetin, prepared by the method which provides a very safe and efficient method that is capable of preparing an extract that exhibits improved antioxidant activity and anticancer activity by increasing the content of the main functional ingredients of natural extracts, and an anticancer agent composition.

公开(公告)号：US09993388B2

公开(公告)日：2018-06-12

申请号：US15102027

申请日：2013-12-27

Applicant: Sjay Medience Co., Ltd.

Inventor： Ki Won Park

IPC: A61H39/00 ,  A43B3/00 ,  A43B3/12 ,  A43B7/14 ,  A61N1/32 ,  A61N1/36 ,  A61H39/04 ,  A43B7/00 ,  A61N1/04

CPC classification number: A61H39/002 ,  A43B3/0005 ,  A43B3/12 ,  A43B3/126 ,  A43B3/128 ,  A43B7/00 ,  A43B7/1445 ,  A43B7/145 ,  A43B7/146 ,  A61H39/04 ,  A61H2201/0165 ,  A61H2201/10 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2201/5033 ,  A61H2201/5043 ,  A61H2205/12 ,  A61H2205/125 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/326 ,  A61N1/36014

Abstract: The present invention relates to a footwear-type growth stimulation apparatus, and more specifically to a growth stimulation apparatus which can give a low-frequency stimulus to a front portion of the sole of the foot of a user who wears it on his/her feet during sleep, can give a continuous stimulus by preventing the feet from being removed therefrom due to twisting and turning during sleep, and can promote the secretion of growth hormone by allowing the weight to be concentrated on the front portion of the sole of the foot even during walking and thus performing continuous Bubbling Spring acupressure.

公开(公告)号：US09694031B2

公开(公告)日：2017-07-04

申请号：US15318315

申请日：2015-06-12

Applicant: MEDIENCE CO., LTD. ,  SMARTNUTRI CO., LTD.

Inventor： Sang Jae Park

IPC: A61K33/10 ,  C01F11/18 ,  A61K9/00 ,  A61K9/68 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K47/02 ,  A61K47/36 ,  A61K47/14 ,  A23L33/16

CPC classification number: A61K33/10 ,  A23L33/16 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K9/16 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/205 ,  A61K9/48 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K33/30 ,  A61K47/02 ,  A61K47/14 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention relates to a calcium carbonate composition for ameliorating, preventing and treating osteoporosis, and a manufacturing method therefor. More specifically, the present invention relates to a calcium carbonate composition for alleviating, preventing and treating osteoporosis, the composition comprising calcium, magnesium and zinc, and having calcium carbonate microparticles formed by the supply of carbon dioxide gas. The present invention provides a composition for maximizing the absorption of calcium, the composition being developed as a health food, food material or the like, and displaying the effects of relieving and alleviating illnesses and symptoms caused by a lack of calcium.

公开(公告)号：US20170143016A1

公开(公告)日：2017-05-25

申请号：US15327990

申请日：2015-07-22

Applicant: MEDIENCE CO., LTD. ,  SMARTNUTRI CO., LTD.

Inventor： Sang Jae PARK ,  Byung Sik KANG

IPC: A23L3/3562 ,  C08B3/12 ,  A23C23/00 ,  A23L5/20 ,  A23C9/142

CPC classification number: A23L3/3562 ,  A23C7/043 ,  A23C9/14 ,  A23C9/142 ,  A23C9/1544 ,  A23C23/00 ,  A23L5/20 ,  A23L5/273 ,  A23L15/00 ,  A23V2002/00 ,  C08B3/12 ,  C08B15/005 ,  C08B37/0012

Abstract: The present invention relates to a structure composed of β-cyclodextrin, a linker and a supporter, and a preparation method thereof. The cellulose-adipate-β-cyclodextrin structure of the present invention is effective in removing cholesterol from foods, and the use of the cellulose-adipate-β-cyclodextrin structure may reduce the onset of adult and chronic diseases due to excessive intake of cholesterol, thereby contributing to maintenance, recovery and promotion of health.

公开(公告)号：US12161138B2

公开(公告)日：2024-12-10

申请号：US17258933

申请日：2018-10-11

Applicant: Medience Co., Ltd.

Inventor： Sang Jae Park

IPC: A23L19/00 ,  A23L2/38 ,  A23L5/43 ,  A61K33/02 ,  A61K36/064 ,  A61K36/8962 ,  A61K47/54

Abstract: The present invention relates to a method for preparation of a fermented Allium tuberosum composition which is obtained by inoculating and fermenting Allium tuberosum with yeast to generate nitrite ions and adding an anthocyanin to stabilize the nitrite ions, and to the fermented Allium tuberosum composition, whereby when ingested into the body, the natural nitrite ions are converted into nitric oxide to induce various biological activities such as hypotension, immunopotentiation, improved blood circulation, and the like. An anthocyanin can be obtained in the form of an extract from aronia, purple corn, black rice, berries such as blueberries and so forth, black bean, and the like and can improve the thermal stability of nitrite ions. Provided are thus a method for preparing a nitrite ion-stabilized, fermented Allium tuberosum liquid by adding an anthocyanin to a fermented Allium tuberosum liquid and a composition thereof.

公开(公告)号：US09907328B2

公开(公告)日：2018-03-06

申请号：US15327990

申请日：2015-07-22

Applicant: MEDIENCE CO., LTD.

Inventor： Sang Jae Park ,  Byung Sik Kang

IPC: A23L1/015 ,  A23L3/3562 ,  A23L5/20 ,  A23C9/142 ,  A23C23/00 ,  C08B3/12 ,  A23C7/04 ,  A23C9/14 ,  C08B15/00 ,  C08B37/16

CPC classification number: A23L3/3562 ,  A23C7/043 ,  A23C9/14 ,  A23C9/142 ,  A23C9/1544 ,  A23C23/00 ,  A23L5/20 ,  A23L5/273 ,  A23L15/00 ,  A23V2002/00 ,  C08B3/12 ,  C08B15/005 ,  C08B37/0012

Abstract: The present invention relates to a structure composed of β-cyclodextrin, a linker and a supporter, and a preparation method thereof. The cellulose-adipate-β-cyclodextrin structure of the present invention is effective in removing cholesterol from foods, and the use of the cellulose-adipate-β-cyclodextrin structure may reduce the onset of adult and chronic diseases due to excessive intake of cholesterol, thereby contributing to maintenance, recovery and promotion of health.

公开(公告)号：US20210321643A1

公开(公告)日：2021-10-21

申请号：US17258933

申请日：2018-10-11

Applicant: Medience Co., Ltd.

Inventor： Sang Jae PARK

IPC: A23L2/38 ,  A61K47/54 ,  A61K33/02 ,  A61K36/8962 ,  A61K36/064 ,  A23L19/00 ,  A23L5/43

Abstract: The present invention relates to a method for preparation of a fermented Allium tuberosum composition which is obtained by inoculating and fermenting Allium tuberosum with yeast to generate nitrite ions and adding an anthocyanin to stabilize the nitrite ions, and to the fermented Allium tuberosum composition, whereby when ingested into the body, the natural nitrite ions are converted into nitric oxide to induce various biological activities such as hypotension, immunopotentiation, improved blood circulation, and the like. An anthocyanin can be obtained in the form of an extract from aronia, purple corn, black rice, berries such as blueberries and so forth, black bean, and the like and can improve the thermal stability of nitrite ions. Provided are thus a method for preparing a nitrite ion-stabilized, fermented Allium tuberosum liquid by adding an anthocyanin to a fermented Allium tuberosum liquid and a composition thereof.

公开(公告)号：US20170119815A1

公开(公告)日：2017-05-04

申请号：US15318315

申请日：2015-06-12

Applicant: MEDIENCE CO., LTD. ,  SMARTNUTRI CO., LTD.

Inventor： Sang Jae PARK

IPC: A61K33/10 ,  A61K9/68 ,  A61K9/16 ,  A23L33/16 ,  A61K9/48 ,  A61K47/02 ,  A61K47/36 ,  A61K47/14 ,  A61K9/00 ,  A61K9/20

CPC classification number: A61K33/10 ,  A23L33/16 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K9/16 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/205 ,  A61K9/48 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K33/30 ,  A61K47/02 ,  A61K47/14 ,  A61K47/36 ,  A61K2300/00

Abstract: The present invention relates to a calcium carbonate composition for ameliorating, preventing and treating osteoporosis, and a manufacturing method therefor. More specifically, the present invention relates to a calcium carbonate composition for alleviating, preventing and treating osteoporosis, the composition comprising calcium, magnesium and zinc, and having calcium carbonate microparticles formed by the supply of carbon dioxide gas. The present invention provides a composition for maximizing the absorption of calcium, the composition being developed as a health food, food material or the like, and displaying the effects of relieving and alleviating illnesses and symptoms caused by a lack of calcium.