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公开(公告)号：US08772010B2
公开(公告)日：2014-07-08
申请号：US13375189
申请日：2010-06-16
申请人： Xiyun Zhang , Jie Yang , Dipnath Baidyaroy , Sally Rhiannon Postlethwaite , Attila Andor , Louis Clark , Lisa M. Newman
发明人： Xiyun Zhang , Jie Yang , Dipnath Baidyaroy , Sally Rhiannon Postlethwaite , Attila Andor , Louis Clark , Lisa M. Newman
CPC分类号： C12N9/2445 , C12N9/2482 , C12Y302/01021 , Y02E50/17
摘要： The invention relates to recombinantly produced β-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
摘要翻译： 本发明涉及与天然存在的蛋白质相比具有增强的热活性的重组产生的和 - 葡萄糖苷酶变体。 本发明还提供用于通过鉴定靶标和葡糖苷酶多肽中的性能敏感位置并用热活性增强残基取代该位置处的残基来制备具有改进的热活性的变体和葡糖苷酶多肽的方法。
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2.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译： 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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公开(公告)号：US20120077216A1
公开(公告)日：2012-03-29
申请号：US13375189
申请日：2010-06-16
申请人： Xiyun Zhang , Jie Yang , Dipnath Baidyaroy , Sally Rhiannon Postlethwaite , Attila Andor , Louis Clark , Lisa M. Newman
发明人： Xiyun Zhang , Jie Yang , Dipnath Baidyaroy , Sally Rhiannon Postlethwaite , Attila Andor , Louis Clark , Lisa M. Newman
CPC分类号： C12N9/2445 , C12N9/2482 , C12Y302/01021 , Y02E50/17
摘要： The invention relates to recombinantly produced β-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant β-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target β-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
摘要翻译： 本发明涉及与天然存在的蛋白质相比具有增强的热活性的重组产生的和 - 葡萄糖苷酶变体。 本发明还提供用于通过鉴定靶标和葡糖苷酶多肽中的性能敏感位置并用热活性增强残基取代该位置处的残基来制备具有改进的热活性的变体和葡糖苷酶多肽的方法。
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4.发明申请RECOMBINANT THERMOASCUS AURANTIACUS BETA-GLUCOSIDASE VARIANTS FOR PRODUCTION OF FERMENTABLE SUGARS FROM CELLULOSIC BIOMASS 失效用于从细胞生物量生产可发酵糖的重组热稳定性乙酰胆碱酯酶变体公开(公告)号：US20110124058A1
公开(公告)日：2011-05-26
申请号：US12950150
申请日：2010-11-19
申请人： Dipnath Baidyaroy , Louis Clark , Lisa M. Newman
发明人： Dipnath Baidyaroy , Louis Clark , Lisa M. Newman
CPC分类号： C12N9/2445 , C12P19/14 , C12Y302/01021 , Y02E50/16 , Y02E50/17
摘要： The present invention provides compositions and methods for the expression of recombinant β-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
摘要翻译： 本发明提供用于表达重组和葡糖苷酶变体的组合物和方法，以及它们在从纤维素生物质生产可发酵糖中的用途。
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公开(公告)号：US20090298125A1
公开(公告)日：2009-12-03
申请号：US12505374
申请日：2009-07-17
申请人： S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa M. Newman
发明人： S. Christopher Davis , Richard J. Fox , Gjalt W. Huisman , Vesna Gavrilovic , Emily C. Mundorff , Lisa M. Newman
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译： 本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。 这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。 本发明还提供相关载体，宿主细胞和方法。
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6.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters 有权用于生产4-取代的3-羟基丁酸衍生物和连位氰基羟基取代的羧酸酯的酶法公开(公告)号：US07132267B2
公开(公告)日：2006-11-07
申请号：US10782258
申请日：2004-02-18
申请人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
发明人： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译： 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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公开(公告)号：US08652813B2
公开(公告)日：2014-02-18
申请号：US12950150
申请日：2010-11-19
申请人： Dipnath Baidyaroy , Louis Clark , Lisa M. Newman
发明人： Dipnath Baidyaroy , Louis Clark , Lisa M. Newman
IPC分类号： C12P19/02
CPC分类号： C12N9/2445 , C12P19/14 , C12Y302/01021 , Y02E50/16 , Y02E50/17
摘要： The present invention provides compositions and methods for the expression of recombinant β-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
摘要翻译： 本发明提供了用于表达重组β-葡糖苷酶变体的组合物和方法，以及它们在从纤维素生物质生产可发酵糖中的用途。
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公开(公告)号：US20120178142A1
公开(公告)日：2012-07-12
申请号：US13290773
申请日：2011-11-07
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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公开(公告)号：US08071347B2
公开(公告)日：2011-12-06
申请号：US12881734
申请日：2010-09-14
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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公开(公告)号：US07820421B2
公开(公告)日：2010-10-26
申请号：US12028780
申请日：2008-02-08
CPC分类号： C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
摘要： The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
摘要翻译： 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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