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1.发明授权Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors 有权用于制备丙型肝炎蛋白酶抑制剂的立体异构纯合并双环脯氨酸化合物公开(公告)号：US08859784B2
公开(公告)日：2014-10-14
申请号：US13294930
申请日：2011-11-11
Applicant: Jack Liang , James Lalonde , Jun Zhu , John M. Gruber , John D. Munger, Jr.
Inventor： Jack Liang , James Lalonde , Jun Zhu , John M. Gruber , John D. Munger, Jr.
IPC: C07D209/02 , C07D403/04 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/18
CPC classification number: C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
Abstract translation: 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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2.发明授权Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine 有权用于从3-芳基-3-酮基丙胺生产3-芳基-3-羟基丙胺的酮还原酶多肽公开(公告)号：US08288141B2
公开(公告)日：2012-10-16
申请号：US12549293
申请日：2009-08-27
Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
Inventor： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
CPC classification number: C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Abstract translation: 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。
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3.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
Applicant: Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
Inventor： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC classification number: C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
Abstract: The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
Abstract translation: 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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4.发明授权Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters 有权用于生产4-取代的3-羟基丁酸衍生物和连位氰基羟基取代的羧酸酯的酶法公开(公告)号：US07132267B2
公开(公告)日：2006-11-07
申请号：US10782258
申请日：2004-02-18
Applicant: S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
Inventor： S. Christopher Davis , John H. Grate , David R. Gray , John M. Gruber , Gjalt W. Huisman , Steven K. Ma , Lisa M. Newman , Roger Sheldon , Li A Wang
IPC: C12P13/00
CPC classification number: C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
Abstract translation: 本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。 本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物 酸酯。
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公开(公告)号：US08877475B2
公开(公告)日：2014-11-04
申请号：US13610166
申请日：2012-09-11
Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
Inventor： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
CPC classification number: C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Abstract translation: 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。
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Patent Agency Ranking
公开(公告)号：US20130005017A1
公开(公告)日：2013-01-03
申请号：US13610166
申请日：2012-09-11
Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
Inventor： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
CPC classification number: C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
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公开(公告)号：US07820421B2
公开(公告)日：2010-10-26
申请号：US12028780
申请日：2008-02-08
Applicant: Charlene Ching , John M. Gruber , Gjalt W. Huisman , Emily Mundorff , Lisa M. Newman
Inventor： Charlene Ching , John M. Gruber , Gjalt W. Huisman , Emily Mundorff , Lisa M. Newman
CPC classification number: C12N9/0006 , C12N15/00 , C12N15/70 , C12Y101/01184
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Abstract translation: 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。
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8.发明申请KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 有权用于制备3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的高聚糖多糖公开(公告)号：US20100173369A1
公开(公告)日：2010-07-08
申请号：US12549293
申请日：2009-08-27
Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
Inventor： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
CPC classification number: C12P17/00 , C12N9/0006 , C12P13/001 , C12Y101/01164 , C12Y101/01184
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Abstract translation: 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化工程化的酮还原酶多肽，用于催化N-甲基-3-酮-3-（2-噻吩基）-1-丙胺向（S）-N-甲基-3-羟基-3-（2-噻吩基） -1-丙胺。
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9.发明申请KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF A 3-ARYL-3-HYDROXYPROPANAMINE FROM A 3-ARYL-3-KETOPROPANAMINE 有权用于生产3-亚氨基-3-羟基丙酰胺的3-氨基-3-羟基丙酰胺的热解聚醚多糖公开(公告)号：US20100151534A1
公开(公告)日：2010-06-17
申请号：US12549154
申请日：2009-08-27
Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
Inventor： Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
CPC classification number: C12N9/0006 , C12P13/001 , C12P17/00 , C12P41/002
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
Abstract translation: 本公开提供与天然存在的野生型酮还原酶相比具有改进性质的工程化酮还原酶。 还提供了编码工程化酮还原酶的多核苷酸，能够表达工程化酮还原酶的宿主细胞，以及使用工程化酮还原酶合成各种手性化合物的方法。 优化了工程化酮还原酶多肽，用于催化N，N-二甲基-3-酮-3-（2-噻吩基）-1-酮基丙胺转化为（S）-N，N-二甲基-3-羟基-3-（ 2-噻吩基）-1-丙胺。
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10.发明申请公开(公告)号：US20100063300A1
公开(公告)日：2010-03-11
申请号：US12490190
申请日：2009-06-23
Applicant: Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
Inventor： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC: C07D209/52
CPC classification number: C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
Abstract translation: 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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