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1.发明授权Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds 有权用于制备基本上立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08178333B2
公开(公告)日：2012-05-15
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein.
摘要翻译： 本公开内容提供单胺氧化酶及其在生物催化方法中用于制备基本上对映异构体纯的以下结构式的杂双环化合物的方法，其中A，M，M'和R 5如本文所述。
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2.发明申请公开(公告)号：US20100063300A1
公开(公告)日：2010-03-11
申请号：US12490190
申请日：2009-06-23
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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公开(公告)号：US08383346B2
公开(公告)日：2013-02-26
申请号：US12562988
申请日：2009-09-18
申请人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
发明人： Jeffrey Colbeck , Benjamin Mijts , Lorraine Joan Giver , Richard J. Fox , Vesna Mitchell , Bumshik Robert Pak , Lynne Gilson
CPC分类号： C12N15/1086 , C12N15/102 , C12N15/1093 , C12Q1/6876 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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4.发明授权Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds 有权用于制备立体异构纯的稠合双环脯氨酸化合物的生物催化方法公开(公告)号：US08574876B2
公开(公告)日：2013-11-05
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, Jr. , Jagadeesh Mavinahalli , Roger Sheldon
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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公开(公告)号：US20090312196A1
公开(公告)日：2009-12-17
申请号：US12483089
申请日：2009-06-11
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及生成包含相对于参照多核苷酸的确定的核苷酸差异的多核苷酸变体文库的方法。
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6.发明申请Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds 有权用于制备立体异构纯双环脯氨酸化合物的生物催化方法公开(公告)号：US20120244581A1
公开(公告)日：2012-09-27
申请号：US13436506
申请日：2012-03-30
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C12P17/10
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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7.发明申请Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors 有权用于制备丙型肝炎蛋白酶抑制剂的独立纯纯双环脯氨酸化合物公开(公告)号：US20120130087A1
公开(公告)日：2012-05-24
申请号：US13294930
申请日：2011-11-11
申请人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
发明人： Benjamin Mijts , Sheela Muley , Jack Liang , Lisa M. Newman , Xiyun Zhang , James Lalonde , Michael D. Clay , Jun Zhu , John M. Gruber , Jeffrey Colbeck , John D. Munger, JR. , Jagadeesh Mavinahalli , Roger Sheldon
IPC分类号： C07D209/52 , C07D487/14
CPC分类号： C07D403/04 , C07D209/02 , C07D403/12 , C07D487/04 , C12P13/24 , C12P17/10 , C12P17/188 , C12Y104/03004
摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。
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公开(公告)号：US20100093560A1
公开(公告)日：2010-04-15
申请号：US12562988
申请日：2009-09-18
CPC分类号： C12N15/1086 , C12N15/102 , C12N15/1093 , C12Q1/6876 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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