Invention Grant
US08288141B2 Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
有权
用于从3-芳基-3-酮基丙胺生产3-芳基-3-羟基丙胺的酮还原酶多肽
- Patent Title: Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
- Patent Title (中): 用于从3-芳基-3-酮基丙胺生产3-芳基-3-羟基丙胺的酮还原酶多肽
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Application No.: US12549293Application Date: 2009-08-27
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Publication No.: US08288141B2Publication Date: 2012-10-16
- Inventor: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
- Applicant: Christopher Savile , John M. Gruber , Emily Mundorff , Gjalt Huisman , Steven James Collier
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N9/04 ; C12P17/12 ; C12P13/00 ; C07H21/04
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
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