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公开(公告)号：US07817840B2
公开(公告)日：2010-10-19
申请号：US11375541
申请日：2006-03-13
申请人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
发明人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067 , G06K9/00147 , G06T7/12 , G06T7/41 , G06T2207/10056 , G06T2207/10064 , G06T2207/20152 , G06T2207/30024
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译： 基于细胞的测定用于评估刺激的肝毒性。 成像技术用于分析刺激对肝细胞的影响。 图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。
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公开(公告)号：US6083913A
公开(公告)日：2000-07-04
申请号：US973225
申请日：1997-12-04
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K38/00 , A61P7/00 , C07K20060101 , C07K7/02 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/52 , A61K39/00 , C07K5/00 , C07K7/00
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： PCT No.PCT / US96 / 09623 Sec。 371 1997年12月4日第 102（e）日期1997年12月4日PCT PCT 1996年6月7日PCT公布。 WO96 / 40750 PCT公开 日期1996年12月19日受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US07235353B2
公开(公告)日：2007-06-26
申请号：US10623486
申请日：2003-07-18
申请人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
发明人： Larry C. Mattheakis , Jay Kenneth Trautman , Gregg Peter Solar , Jinhong Fan , Eugeni Vaisberg , Cynthia Lynn Adams , Aibing Rao
CPC分类号： G06T7/0012 , G01N1/30 , G01N33/5067
摘要： Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the stimulus on the basis of whether it is hepatotoxic, and if so what type of pathology is exhibited; e.g., apoptosis, necrosis, cholestasis, and/or steatosis.
摘要翻译： 基于细胞的测定用于评估刺激的肝毒性。 成像技术用于分析刺激对肝细胞的影响。 图像分析可以基于是否具有肝毒性来表征刺激，如果是这样的病理学展示; 例如凋亡，坏死，胆汁郁积和/或脂肪变性。
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公开(公告)号：US07091311B2
公开(公告)日：2006-08-15
申请号：US10083768
申请日：2002-02-27
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06465430B1
公开(公告)日：2002-10-15
申请号：US09549090
申请日：2000-04-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K3800
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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6.发明授权Method for enhancing transport of semiconductor nanocrystals across biological membranes 有权增强生物膜上半导体纳米晶体传输的方法公开(公告)号：US08993349B2
公开(公告)日：2015-03-31
申请号：US12905950
申请日：2010-10-15
申请人： Marcel P. Bruchez , R. Hugh Daniels , Jennifer Dias , Larry C. Mattheakis , Hongjian Liu , Aquanette M. Burt , Berndt Christoffer Lagerholm , Danith H. Ly
发明人： Marcel P. Bruchez , R. Hugh Daniels , Jennifer Dias , Larry C. Mattheakis , Hongjian Liu , Aquanette M. Burt , Berndt Christoffer Lagerholm , Danith H. Ly
IPC分类号： G01N33/532 , G01N33/543 , G01N33/551 , G01N21/76 , G01N33/58 , B82Y15/00 , G01N33/50
CPC分类号： G01N33/588 , B82Y15/00 , C07K7/06 , G01N33/5008 , G01N33/5014 , G01N33/5076 , G01N33/566 , G01N2333/726 , G01N2500/10
摘要： Semiconductor nanoparticle complexes comprising semiconductor nanoparticles in association with cationic polymers are described. Also described are methods for enhancing the transport of semiconductor nanoparticles across biological membranes to provide encoded cells. The methods are particularly useful in multiplex settings where a plurality of encoded cells are to be assayed. Kits comprising reagents for performing such methods are also provided.
摘要翻译： 描述了包含与阳离子聚合物结合的半导体纳米颗粒的半导体纳米颗粒络合物。 还描述了用于增强半导体纳米颗粒在生物膜上的转运以提供编码细胞的方法。 该方法在多重设置中特别有用，其中要测定多个编码的细胞。 还提供了包含用于执行这些方法的试剂的试剂盒。
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公开(公告)号：US08227422B2
公开(公告)日：2012-07-24
申请号：US11610226
申请日：2006-12-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US5922545A
公开(公告)日：1999-07-13
申请号：US902623
申请日：1997-07-29
CPC分类号： C07K16/1285 , C07K16/00 , C07K2317/34
摘要： Improved methods and novel compositions for identifying peptides and single-chain antibodies that bind to predetermined receptors or epitopes. Such peptides and antibodies are identified by improved and novel methods for affinity screening of polysomes displaying nascent peptides.
摘要翻译： 用于鉴定结合预定受体或表位的肽和单链抗体的改进方法和新型组合物。 通过用于亲和筛选显示新生肽的多核糖体的改进和新颖的方法来鉴定这些肽和抗体。
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公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US06309842B1
公开(公告)日：2001-10-30
申请号：US08977378
申请日：1997-11-24
申请人： William J. Dower , Christian M. Gates , Gregory L. Heinkel , Guy Lalonde , Larry C. Mattheakis , Christopher J. Paddon , Peter J. Schatz
发明人： William J. Dower , Christian M. Gates , Gregory L. Heinkel , Guy Lalonde , Larry C. Mattheakis , Christopher J. Paddon , Peter J. Schatz
IPC分类号： G01N3353
CPC分类号： G01N33/566 , C40B40/00 , G01N33/532 , G01N33/54306 , G01N2500/00
摘要： The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
摘要翻译： 本发明提供了筛选具有所需性质，特别是激动，结合或拮抗细胞受体的能力的化合物的复合物文库的方法。 这些文库中的络合物包括被测化合物，记录化合物合成中至少一个步骤的标签，以及易受报道分子修饰的系链。 系链的修饰用于表示复合物含有具有所需性质的化合物。 可以对标签进行解码以显示合成这种化合物的至少一个步骤。
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