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公开(公告)号：US20110245176A1
公开(公告)日：2011-10-06
申请号：US12945687
申请日：2010-11-12
申请人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Balu Palani , Genet Zemede
发明人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Balu Palani , Genet Zemede
CPC分类号： C07K14/001 , A61K38/00 , A61K47/60 , C07K14/505 , C07K2319/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译： 本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。 本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物。
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公开(公告)号：US20090048166A1
公开(公告)日：2009-02-19
申请号：US12171610
申请日：2008-07-11
申请人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Balu Palani , Genet Zemede
发明人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Balu Palani , Genet Zemede
CPC分类号： C07K14/001 , A61K38/00 , A61K47/60 , C07K14/505 , C07K2319/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译： 本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。 本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物。
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公开(公告)号：US07091311B2
公开(公告)日：2006-08-15
申请号：US10083768
申请日：2002-02-27
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06465430B1
公开(公告)日：2002-10-15
申请号：US09549090
申请日：2000-04-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K3800
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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5.发明授权Compositions and methods for detecting ligand-dependent nuclear receptor and coactivator interactions 失效用于检测配体依赖性核受体和共激活剂相互作用的组合物和方法公开(公告)号：US06410245B1
公开(公告)日：2002-06-25
申请号：US09053611
申请日：1998-04-01
IPC分类号： G01N3353
CPC分类号： G01N33/6872 , C07K7/06 , C07K7/08 , C12N15/1055 , G01N33/5008 , G01N33/5041 , G01N33/5047 , G01N33/5067 , G01N33/5073 , G01N33/581 , G01N33/6875
摘要： The invention provides methods for identifying agents that are ligands for nuclear receptors. The methods include conducting multiplexed assays utilizing positive hybrid systems, reverse hybrid systems, direct interaction assays and other assays to screen for ligands having activity with a receptor of interest. The methods can be performed in various multiplexing formats to produce a profile that can be used to categorize a test ligand relative to known agonists and antagonists.
摘要翻译： 本发明提供了鉴定作为核受体配体的试剂的方法。 所述方法包括利用阳性杂交系统进行多重测定，反向杂交系统，直接相互作用测定和其它测定以筛选具有感兴趣受体活性的配体。 这些方法可以以各种复用形式进行，以产生可用于相对于已知的激动剂和拮抗剂分类测试配体的分布。
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公开(公告)号：US6121238A
公开(公告)日：2000-09-19
申请号：US244298
申请日：1999-02-03
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
CPC分类号： C07K14/524 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US5338665A
公开(公告)日：1994-08-16
申请号：US963321
申请日：1992-10-15
CPC分类号： G01N33/68 , C12N15/1075
摘要： A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also contain a binding site for the DNA binding protein can be used to screen for novel ligands. The screening method results in the formation of a complex comprising the fusion protein bound to a receptor through the random peptide ligand and to the recombinant DNA vector through the DNA binding protein.
摘要翻译： 通过用编码由DNA结合蛋白和随机肽组成的融合蛋白的重组载体的集合转化宿主细胞构建的随机肽文库，并且还含有DNA结合蛋白的结合位点，可用于筛选新配体。 筛选方法导致通过DNA结合蛋白形成包含通过随机肽配体与受体结合的融合蛋白和重组DNA载体的复合物。
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公开(公告)号：US08729030B2
公开(公告)日：2014-05-20
申请号：US12945687
申请日：2010-11-12
申请人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Palani Balu , Genet Zemede
发明人： Christopher P. Holmes , Qun Yin , Guy Lalonde , Peter J. Schatz , David Tumelty , Palani Balu , Genet Zemede
IPC分类号： C07K7/08 , C07K14/505 , A61K38/10 , C07K17/08
CPC分类号： C07K14/001 , A61K38/00 , A61K47/60 , C07K14/505 , C07K2319/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译： 本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。 本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞产生相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物。
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公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US20090005292A1
公开(公告)日：2009-01-01
申请号：US11718998
申请日：2005-11-11
申请人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , David Tumelty , Guy Lalonde , Palani Balu , Peter J. Schatz , William J. Dower , Anjan Chakrabarti , Yaohua S. Dong , Brian T. Frederick , Nicholas C. Wrighton
发明人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , David Tumelty , Guy Lalonde , Palani Balu , Peter J. Schatz , William J. Dower , Anjan Chakrabarti , Yaohua S. Dong , Brian T. Frederick , Nicholas C. Wrighton
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译： 本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。 本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞生成相关的疾病的治疗方法。 还提供了包含本发明的肽化合物的药物组合物。
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