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公开(公告)号：US20090214489A1
公开(公告)日：2009-08-27
申请号：US12103377
申请日：2008-04-15
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US06309889B1
公开(公告)日：2001-10-30
申请号：US09470689
申请日：1999-12-23
IPC分类号： C12Q102
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/00423 , B01J2219/005 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/0072 , B01J2219/0074 , B01J2219/00743 , B01L2300/0819 , B81B1/00 , C40B60/14 , G01N33/5005
摘要： The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface, and a plurality of holding locations that are adapted to hold at least one article, such as a solid support and/or a cell. When within the holding locations, the articles are preferably disposed below the top surface. A membrane is positioned above the top surface of the holding member, and a pressure system is provided to apply positive pressure to the membrane to force the membrane against the top surface of the holding member. In this way, a seal may be provided between the holding locations.
摘要翻译： 本发明提供了促进测定性能的示例性装置和方法。 在一个实施例中，一个这样的装置包括具有顶表面，底表面和多个保持位置的保持构件，所述保持位置适于容纳至少一个物品，例如固体支撑体和/或细胞。 当在保持位置内时，物品优选地设置在顶面下方。 膜位于保持构件的顶表面上方，并且提供压力系统以向膜施加正压力以迫使膜抵靠保持构件的顶表面。 以这种方式，可以在保持位置之间设置密封。
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公开(公告)号：US6083913A
公开(公告)日：2000-07-04
申请号：US973225
申请日：1997-12-04
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K38/00 , A61P7/00 , C07K20060101 , C07K7/02 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/52 , A61K39/00 , C07K5/00 , C07K7/00
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： PCT No.PCT / US96 / 09623 Sec。 371 1997年12月4日第 102（e）日期1997年12月4日PCT PCT 1996年6月7日PCT公布。 WO96 / 40750 PCT公开 日期1996年12月19日受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US07091311B2
公开(公告)日：2006-08-15
申请号：US10083768
申请日：2002-02-27
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06465430B1
公开(公告)日：2002-10-15
申请号：US09549090
申请日：2000-04-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： A61K3800
摘要： Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 受体是结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US6121238A
公开(公告)日：2000-09-19
申请号：US244298
申请日：1999-02-03
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
CPC分类号： C07K14/524 , A61K38/00
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
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公开(公告)号：US06506362B1
公开(公告)日：2003-01-14
申请号：US09832230
申请日：2001-04-10
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3819
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US08227422B2
公开(公告)日：2012-07-24
申请号：US11610226
申请日：2006-12-13
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , David J. Duffin , Christian M. Gates , Sherril S. Haselden , Larry C. Mattheakis , Peter J. Schatz , Christopher R. Wagstrom , Nicholas C. Wrighton
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00 , C07K7/64 , C07K14/521 , C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US06251864B1
公开(公告)日：2001-06-26
申请号：US09516704
申请日：2000-03-01
申请人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
发明人： William J. Dower , Ronald W. Barrett , Steven E. Cwirla , Christian M. Gates , Peter J. Schatz , Palaniappan Balasubramanian , Christopher R. Wagstrom , Richard Wayne Hendren , Randolph B. Deprince , Surekha Podduturi , Qun Yin
IPC分类号： A61K3800
CPC分类号： C07K14/524
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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公开(公告)号：US5932546A
公开(公告)日：1999-08-03
申请号：US726464
申请日：1996-10-04
申请人： Ronald W. Barrett , William J. Dower , Steven E. Cwirla , Sherril S. Johnson , Nicholas C. Wrighton , David J. Duffin , Christopher R. Wagstrom
发明人： Ronald W. Barrett , William J. Dower , Steven E. Cwirla , Sherril S. Johnson , Nicholas C. Wrighton , David J. Duffin , Christopher R. Wagstrom
摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。
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