知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

57 条记录 (耗时 0.037 秒)

    Electroactive Scaffold
    4.
    发明申请
    Electroactive Scaffold 有权
    电动支架

    公开(公告)号：US20110142806A1

    公开(公告)日：2011-06-16

    申请号：US12969076

    申请日：2010-12-15

    申请人： Lisa A. Scott-Carnell ,  Emilie J. Siochi ,  Nancy M. Holloway ,  Kam W. Leong ,  Karina Kulangara

    发明人： Lisa A. Scott-Carnell ,  Emilie J. Siochi ,  Nancy M. Holloway ,  Kam W. Leong ,  Karina Kulangara

    IPC分类号： A61K35/12 ,  C12N5/071 ,  C12N13/00 ,  A61P25/00 ,  A61P37/00 ,  B29C47/00

    CPC分类号： C12N5/0068 ,  A61K35/12 ,  A61K35/28 ,  A61L27/16 ,  A61L27/3834 ,  C12N11/08 ,  C12N13/00 ,  C12N2529/00 ,  C12N2533/30 ,  C08L27/16

    摘要： A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound.

    摘要翻译： 公开了制造和/或使用用于干细胞培养和组织工程应用的支架的支架组件和相关方法，其通过使用电活性材料提供生物化学，地形学，机械和电学提示，至少部分地模拟天然生物环境。 该组件包括至少一层基本对准的电纺聚合物纤维，其具有用于单独电压施加的操作连接。 细胞组织工程和/或干细胞分化的方法利用悬浮在细胞培养基中的细胞样品接种组合物，孵育并施加电压至一层或多层，从而产生细胞和/或组织构建体。 另一方面，本发明提供一种制造组件的方法，其包括以下步骤：提供第一预电镀基底表面; 将第一基本上排列的聚合物纤维层静电纺丝到第一表面上; 提供第二预电镀衬底表面; 将第二基本上排列的聚合物纤维层静电纺丝到第二表面上; 并且用夹具和/或粘合剂化合物将层压表面保持在一起。

    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
    6.
    发明授权
    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same 有权
    可生物降解的对苯二甲酸酯聚酯 - 聚（亚磷酸酯）组合物，制品及其使用方法

    公开(公告)号：US06419709B1

    公开(公告)日：2002-07-16

    申请号：US09165373

    申请日：1998-10-02

    申请人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    发明人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    IPC分类号： C08G7902

    CPC分类号： C08G63/6926 ,  A61K9/0024 ,  A61K9/1647 ,  A61L17/105 ,  A61L24/046 ,  A61L31/06 ,  C08L67/00

    摘要： An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; x is ≧1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

    摘要翻译： 描述了一种基本上非骨传导性医疗装置，其包含可生物降解的对苯二甲酸酯共聚物，其包含式I所示的重复单体单元：其中R是二价有机部分;x≥1; andn为3-7,500，其中生物可降解聚合物足够纯以生物相容性，并且在生物降解时能够形成生物相容性残基。含有共聚物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及 还描述了使用共聚物可控地释放生物活性物质的方法。

    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    7.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 有权
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US06376644B1

    公开(公告)日：2002-04-23

    申请号：US09654326

    申请日：2000-09-01

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： C08G7904

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is —O— or —NR′—, where R′ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is —O—, —S— or —NR′—, where R′ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。