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    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    1.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 失效
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US6166173A

    公开(公告)日：2000-12-26

    申请号：US53649

    申请日：1998-04-02

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61L27/00 ,  A61K9/00 ,  A61K9/16 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/14 ,  A61L27/18 ,  C08G63/692 ,  C08G63/91 ,  C08G69/42 ,  C08G79/04 ,  C08L67/00 ,  C08L77/00 ,  C08L85/02 ,  C08L101/16 ,  A61K31/80

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    3.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 失效
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06403675B1

    公开(公告)日：2002-06-11

    申请号：US09070204

    申请日：1998-04-30

    申请人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L是二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。 还描述了除了聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法。

    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
    6.
    发明授权
    Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same 有权
    可生物降解的对苯二甲酸酯聚酯 - 聚（亚磷酸酯）组合物，制品及其使用方法

    公开(公告)号：US06419709B1

    公开(公告)日：2002-07-16

    申请号：US09165373

    申请日：1998-10-02

    申请人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    发明人： Hai-quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  Wensin Dang ,  James P. English ,  David P. Nowotnik

    IPC分类号： C08G7902

    CPC分类号： C08G63/6926 ,  A61K9/0024 ,  A61K9/1647 ,  A61L17/105 ,  A61L24/046 ,  A61L31/06 ,  C08L67/00

    摘要： An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; x is ≧1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

    摘要翻译： 描述了一种基本上非骨传导性医疗装置，其包含可生物降解的对苯二甲酸酯共聚物，其包含式I所示的重复单体单元：其中R是二价有机部分;x≥1; andn为3-7,500，其中生物可降解聚合物足够纯以生物相容性，并且在生物降解时能够形成生物相容性残基。含有共聚物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及 还描述了使用共聚物可控地释放生物活性物质的方法。

    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
    7.
    发明授权
    Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same 有权
    通过磷酸盐，组合物，制品和制造和使用它们的方法延伸的可生物降解的聚合物

    公开(公告)号：US06376644B1

    公开(公告)日：2002-04-23

    申请号：US09654326

    申请日：2000-09-01

    申请人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Hai-Quan Mao ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： C08G7904

    CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61L17/12 ,  A61L26/0019 ,  A61L27/18 ,  C08G63/6922 ,  C08G63/912 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is —O— or —NR′—, where R′ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M1 and M2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is —O—, —S— or —NR′—, where R′ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

    摘要翻译： 描述包含式I或II所示的重复单体单元的生物可降解聚合物：其中X是-O-或-NR'-，其中R'是H或烷基; L是具有1-20个碳原子的支链或直链脂族基团; M1和M2各自独立地为（1）具有1-20个碳原子的支链或直链脂族基团; 或（2）具有1-20个碳原子的支链或直链，氧基，羧基或氨基 - 脂族基团; Y是-O - ， - S-或-NR'-，其中R'是H或烷基; R是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; x：y的摩尔比为约1; 摩尔比n：（x或y）在约200:1和1:200之间; 并且摩尔比q：r在约1:99和99:1之间; 其中所述可生物降解聚合物在生物降解之前和之后是生物相容的。 还描述了制备聚合物的方法，含有聚合物和生物活性物质的组合物，用于植入或注射到由组合物制造的身体中的制品，以及使用该聚合物可控地释放生物活性物质的方法。

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    8.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 有权
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06800672B2

    公开(公告)日：2004-10-05

    申请号：US10011570

    申请日：2001-12-04

    申请人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    发明人： Wenbin Dang ,  Irina Kadiyala ,  Zhong Zhao ,  James P. English ,  Hai-quan Mao ,  Kam W. Leong

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L为二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。除聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法也是 描述。

    Two-stage solution polymerization of high molecular weight poly(phosphoesters)
    10.
    发明授权
    Two-stage solution polymerization of high molecular weight poly(phosphoesters) 失效
    高分子量聚（磷酸酯）的两阶段溶液聚合

    公开(公告)号：US6008318A

    公开(公告)日：1999-12-28

    申请号：US98620

    申请日：1998-06-17

    申请人： Zhong Zhao ,  Hai-quan Mao ,  Kam W. Leong

    发明人： Zhong Zhao ,  Hai-quan Mao ,  Kam W. Leong

    IPC分类号： C08G79/04 ,  C08G79/02

    CPC分类号： C08G79/04

    摘要： A process for making a phosphoester polymer comprising the recurring monomeric units of formula I: ##STR1## wherein: X is --O-- or --NR"--, where R" is H or alkyl;L is a divalent organic moiety;R' is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic, or heterocycloxy; andn is between about 25 to 2,000,is described. The process comprises the steps of:(a) polymerizing in the presence of a solvent p moles of a di-XH compound having formula II:H--X--L--X--H II wherein X and L are as defined above, with q moles, where p.apprxeq.q, of a phosphorodihalo compound to form a polymer of formula I, wherein n is about 12 to 1000, having a first molecular weight Mw.sub.1, wherein the solvent is present in an amount greater than about 5 ml of solvent per gram of compound of formula II;(b) removing at least about 25% of the solvent to form a more concentrated reaction mixture; and(c) further polymerizing the concentrated reaction mixture for an additional time sufficient to produce a polymer of formula I wherein n is between about 25 and 2,000, the polymer having a second molecular weight Mw.sub.2, which is significantly higher than Mw.sub.1.

    摘要翻译： 制备含有式I的重复单体单元的磷酸酯聚合物的方法：其中：X是-O-或-NR“ - ，其中R”是H或烷基; L是二价有机部分; R'是H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; 并且n在约25至2,000之间。 该方法包括以下步骤：（a）在溶剂的存在下聚合，其中p摩尔的q摩尔具有式II的二-XH化合物：其中X和L如上所定义，其中X和L如上所定义，其中p APPROX q， 的二卤代化合物以形成式I的聚合物，其中n为约12至1000，具有第一分子量Mw1，其中溶剂的存在量为每克式II化合物大于约5ml溶剂; （b）除去至少约25％的溶剂以形成更浓缩的反应混合物; 并且（c）将浓缩的反应混合物进一步聚合另外的时间足以产生其中n在约25和2,000之间的式I的聚合物，该聚合物具有明显高于Mw1的第二分子量Mw2。