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6 条记录 (耗时 0.012 秒)

    Compositions of oral gene therapy and methods of using same
    1.
    发明申请
    Compositions of oral gene therapy and methods of using same 审中-公开
    口服基因治疗的组合及使用方法

    公开(公告)号：US20060051424A1

    公开(公告)日：2006-03-09

    申请号：US10491544

    申请日：2002-10-03

    申请人： Kam Leong ,  Grace Okoli ,  Gonzalo Hortelano

    发明人： Kam Leong ,  Grace Okoli ,  Gonzalo Hortelano

    IPC分类号： A61K48/00 ,  A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/5161 ,  A61K9/5036 ,  A61K38/4846 ,  A61K48/00 ,  A61K48/0041 ,  A61K48/0075

    摘要： The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy.

    摘要翻译： 本发明提供包含阳离子生物聚合物和至少一种生物活性物质的纳米颗粒组合物，包含这样的纳米颗粒的药物组合物和用于口服施用使用纳米颗粒在胃肠道中降解的生物活性分子的方法。 本发明还提供了口服基因治疗的组合物和方法。

    Oral administration of therapeutic agent coupled to transporting agent
    3.
    发明申请
    Oral administration of therapeutic agent coupled to transporting agent 审中-公开
    口服给药与治疗剂偶联运输剂

    公开(公告)号：US20050208032A1

    公开(公告)日：2005-09-22

    申请号：US11039679

    申请日：2005-01-18

    申请人： Gonzalo Hortelano ,  Gomez Vargas

    发明人： Gonzalo Hortelano ,  Gomez Vargas

    IPC分类号： A61K48/00 ,  C07K14/47 ,  C12N15/85

    CPC分类号： C07K14/4702 ,  A61K48/0075

    摘要： The present invention is directed toward a composition for widespread distribution, systemic expression and sustained delivery of a therapeutic or transdifferentiating agent and to a process for administration of said agent via a natural gastrointestinal pathway. More particularly, the invention discloses a composition for the administration of oral gene therapy and a process for its production and use.

    摘要翻译： 本发明涉及用于治疗性或转分化剂的广泛分布，全身表达和持续递送的组合物以及通过天然胃肠途径给药所述药物的方法。 更具体地，本发明公开了一种用于口服基因治疗的组合物及其生产和使用的方法。

    Oral administration of therapeutic agent coupled to transporting agent induces tolerance
    5.
    发明申请
    Oral administration of therapeutic agent coupled to transporting agent induces tolerance 审中-公开
    口服施用与转运剂偶联的治疗剂诱导耐受

    公开(公告)号：US20060178336A1

    公开(公告)日：2006-08-10

    申请号：US11399023

    申请日：2006-04-06

    申请人： Gonzalo Hortelano ,  Andrew Vargas

    发明人： Gonzalo Hortelano ,  Andrew Vargas

    IPC分类号： A61K48/00

    CPC分类号： B82Y5/00 ,  A61K9/0031 ,  A61K9/5015 ,  A61K9/5052 ,  A61K47/61 ,  A61K47/645 ,  A61K47/6927 ,  A61K47/6929 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/0075 ,  A61K2039/542

    摘要： The present invention is directed toward a method for the induction of tolerance to a foreign transgene or a self-antigen in an animal host by administration of a composition to an animal host via a natural gastrointestinal pathway. Additionally, the present method can eliminate a pre-existing immune response in an animal host. The composition administered when carrying out the method achieves widespread distribution, systemic expression and sustained delivery of a genetic material in an animal host. More particularly, the invention discloses a method useful for both eliciting tolerance and for abrogation of a pre-existing immune response by oral administration of a genetic material.

    摘要翻译： 本发明涉及通过经由天然胃肠途径向动物宿主施用组合物来诱导对动物宿主中外源转基因或自身抗原的耐受性的方法。 另外，本发明的方法可以消除动物宿主中预先存在的免疫应答。 在实施该方法时施用的组合物在动物宿主中实现遗传物质的广泛分布，系统表达和持续递送。 更具体地说，本发明公开了一种有利于通过口服施用遗传物质引起耐受性和消除预先存在的免疫应答的方法。