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公开(公告)号：US08592402B2
公开(公告)日：2013-11-26
申请号：US13388502
申请日：2010-08-03
IPC分类号： A61K31/56 , A61K31/42 , C07D261/14
CPC分类号： C07D261/14 , A61K31/42 , A61K31/4427 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07F9/653
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号：US08426449B2
公开(公告)日：2013-04-23
申请号：US12935253
申请日：2009-03-25
IPC分类号： A01N43/40 , C07D213/62 , C07D229/00
CPC分类号： C07C233/62 , C07C217/58 , C07C233/18 , C07C233/43 , C07C233/73 , C07C271/16 , C07C271/20 , C07C271/24 , C07C311/08 , C07C311/17 , C07C311/29 , C07C311/40 , C07C317/14 , C07C2601/02 , C07C2602/08
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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3.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08362044B2
公开(公告)日：2013-01-29
申请号：US13272180
申请日：2011-10-12
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20130005721A1
公开(公告)日：2013-01-03
申请号：US13497517
申请日：2010-09-23
申请人： Brian Andrew Stearns , Jeffrey Roger Roppe , Timothy Andrew Parr , Nicholas Simon Stock , Deborah Volkots , John Howard Hutchinson
发明人： Brian Andrew Stearns , Jeffrey Roger Roppe , Timothy Andrew Parr , Nicholas Simon Stock , Deborah Volkots , John Howard Hutchinson
IPC分类号： A61K31/437 , A61K31/5377 , A61K31/4709 , A61K31/444 , A61K31/506 , A61P29/00 , A61P11/00 , A61P9/00 , A61P11/06 , A61P9/10 , A61P9/12 , A61P25/00 , A61P11/02 , A61P19/02 , A61P35/00 , A61P3/00 , C07D471/04
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/0078 , A61K9/06 , A61K9/1652 , A61K9/4866 , A61K47/38
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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公开(公告)号：US08247602B2
公开(公告)日：2012-08-21
申请号：US13246688
申请日：2011-09-27
IPC分类号： C07C323/57 , C07C321/20 , C07C229/18 , A61K31/167 , A61K31/10
CPC分类号： C07C323/42 , A61K31/235 , C07C317/28 , C07C323/41 , C07C323/44 , C07C323/49 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110301211A1
公开(公告)日：2011-12-08
申请号：US13139260
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42 , C07D413/10 , A61K31/422 , A61P1/16 , A61P17/00 , A61P35/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P1/00 , A61P13/12 , A61P13/02 , A61P13/00 , A61P1/18 , A61P9/10 , A61P7/04 , A61P11/06 , A61P35/02 , A61P35/04 , A61P27/02 , C07D261/14
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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7.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08067445B2
公开(公告)日：2011-11-29
申请号：US12865342
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195 , C07D213/64 , C07C229/00
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110144160A1
公开(公告)日：2011-06-16
申请号：US12999617
申请日：2009-07-02
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Brian Andrew Stearns
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Brian Andrew Stearns
IPC分类号： A61K31/445 , A61K31/44 , A61K31/433 , A61K31/42 , A61K31/4166 , A61K31/195 , C07D211/06 , C07D211/72 , C07D285/12 , C07D263/00 , C07D233/70 , C07C321/16 , C07C317/06
CPC分类号： C07C323/42 , A61K31/235 , C07C317/28 , C07C323/41 , C07C323/44 , C07C323/49 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110112106A1
公开(公告)日：2011-05-12
申请号：US12987004
申请日：2011-01-07
申请人： John Howard HUTCHINSON , Thomas Jonathan SEIDERS , Brian Andrew STEARNS , Bowei WANG , Jill Melissa SCOTT , Yen Pham TRUONG
发明人： John Howard HUTCHINSON , Thomas Jonathan SEIDERS , Brian Andrew STEARNS , Bowei WANG , Jill Melissa SCOTT , Yen Pham TRUONG
IPC分类号： A61K31/4985 , C07D471/04 , A61K31/437 , A61P29/00 , A61P3/00 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.
摘要翻译： 本文描述了含有抑制5-脂氧合酶（5-LO）活性的这些化合物的化合物和药物组合物。 本文还描述了使用这种单独的和与其它化合物组合的这种5-LO抑制剂来治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症，疾病或病症的方法。
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10.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20110098352A1
公开(公告)日：2011-04-28
申请号：US12864859
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
IPC分类号： A61K31/195 , C07C229/34 , C07C271/10 , A61K31/27 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06
CPC分类号： C07C233/47 , C07C233/63 , C07C235/12 , C07C235/20 , C07C271/22 , C07C275/24 , C07C317/50 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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