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公开(公告)号：US08524748B2
公开(公告)日：2013-09-03
申请号：US13123196
申请日：2009-10-07
IPC分类号： A61K31/433 , A61K31/192 , A61K31/216 , C07D285/08
CPC分类号： C07D285/12 , A61K31/41 , A61K31/433 , A61K45/06 , C07C59/68 , C07C317/46 , C07C323/56 , A61K2300/00
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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公开(公告)号：US08273780B2
公开(公告)日：2012-09-25
申请号：US13246746
申请日：2011-09-27
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42
CPC分类号： A61K31/42 , C07D261/14
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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3.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 有权PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20120059055A1
公开(公告)日：2012-03-08
申请号：US13297160
申请日：2011-11-15
申请人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
发明人： John Howard HUTCHINSON , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
IPC分类号： A61K31/27 , C07C233/51 , C07C311/13 , C07C317/50 , C07C275/24 , C07C271/34 , C07C235/34 , C07C233/63 , A61K31/195 , A61P11/00 , A61P37/08 , A61P29/00 , A61P11/06 , A61P11/02 , C07C271/22
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20120022119A1
公开(公告)日：2012-01-26
申请号：US13129078
申请日：2009-11-16
申请人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
发明人： John Howard Hutchinson , Nicholas Simon Stock , Jeffrey Roger Roppe , Brian Andrew Stearns , Timothy Parr
IPC分类号： A61K31/4245 , C07D231/12 , C07D271/06 , A61K31/4155 , A61K31/415 , A61P11/06 , A61P17/06 , A61P9/12 , A61P11/14 , A61P9/00 , A61P35/00 , A61P19/02 , A61P29/00 , A61P9/10 , A61P11/08 , A61P11/12 , A61P11/02 , A61P37/08 , A61P11/00 , A61P1/00 , A61P7/10 , A61P43/00 , C07D403/06
CPC分类号： C07D403/06 , A61K31/4174 , A61K31/4178 , C07D231/12 , C07D271/06
摘要： Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的杂芳基化合物。 还描述了包括所述杂芳基化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110301142A1
公开(公告)日：2011-12-08
申请号：US13139271
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr , Lucy Zhao
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr , Lucy Zhao
IPC分类号： A61K31/444 , C07D261/14 , C07D413/12 , C07D413/04 , C07D417/10 , A61P35/00 , C07D413/14 , A61K31/422 , A61K31/42 , A61K31/4439 , A61K31/427 , C07D413/10 , C07D417/04
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US08048902B2
公开(公告)日：2011-11-01
申请号：US12638702
申请日：2009-12-15
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42 , C07D261/14
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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7.发明申请公开(公告)号：US20110245303A1
公开(公告)日：2011-10-06
申请号：US13123196
申请日：2009-10-07
IPC分类号： A61K31/433 , C07C53/23 , A61K31/192 , C07C69/712 , A61K31/216 , C07D285/08 , A61P11/06 , A61P11/00 , A61P9/00 , A61P17/06 , A61P1/00 , A61P35/00 , A61P17/02
CPC分类号： C07D285/12 , A61K31/41 , A61K31/433 , A61K45/06 , C07C59/68 , C07C317/46 , C07C323/56 , A61K2300/00
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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公开(公告)号：US20110196005A1
公开(公告)日：2011-08-11
申请号：US13092860
申请日：2011-04-22
申请人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
发明人： John Howard Hutchinson , Thomas Jon Seiders , Bowei Wang , Jeannie M. Arruda , Jeffrey Roger Roppe , Timothy Parr
IPC分类号： A61K31/42 , A61K31/422 , A61P35/00
CPC分类号： C07D261/14 , C07D413/10
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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公开(公告)号：US08399666B2
公开(公告)日：2013-03-19
申请号：US12089707
申请日：2006-10-30
申请人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
发明人： John H. Hutchinson , Petpiboon Peppi Prasit , Mark Moran , Jillian F. Evans , Brian Andrew Stearns , Jeffrey Roger Roppe , Yiwei Li , Jasmine Eleanor Zunic , Jeannie M. Arruda , Nicholas Simon Stock , Mustapha Haddach
IPC分类号： A61P9/00 , A61P11/00 , A61P29/00 , C07D401/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.
摘要翻译： 本文描述了含有调节5-脂氧合酶活化蛋白（FLAP）的活性的化合物的化合物和药物组合物。 本文还描述了使用这样的FLAP调节剂单独和与其它化合物组合用于治疗呼吸，心血管和其它白三烯依赖性或白细胞三烯介导的病症或疾病的方法。
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10.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08362044B2
公开(公告)日：2013-01-29
申请号：US13272180
申请日：2011-10-12
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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