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    TOOTH SCAFFOLDS
    5.
    发明申请
    TOOTH SCAFFOLDS 有权
    牙齿痉挛

    公开(公告)号：US20120282573A1

    公开(公告)日：2012-11-08

    申请号：US13378789

    申请日：2010-06-17

    申请人： Jeremy J. Mao

    发明人： Jeremy J. Mao

    IPC分类号： A61C13/08

    CPC分类号： A61L27/48 ,  A61C8/0036 ,  A61K35/12 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/45 ,  A61L2300/622 ,  A61L2430/12 ,  C12N5/0654 ,  C12N2501/155 ,  C12N2501/21 ,  C12N2533/18 ,  C12N2533/40 ,  C12N2533/54 ,  C08L67/04

    摘要： Provided is an acellular mammalian tooth-shaped scaffold comprising a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.

    摘要翻译： 提供了一种无细胞哺乳动物的牙齿支架，其包含具有趋化性，成骨，牙质发生，萌生或成骨的化合物。 还提供了一种替代牙齿不存在的口腔中的牙齿，并且在缺牙处的位置处存在牙槽的方法。 该方法包括将具有缺牙的形状的无细胞支架植入牙槽内。 另外，提供了制造牙齿支架的方法。 该方法包括合成哺乳动物牙齿形状的无细胞支架，并加入至少一种化学趋化性，成骨性，牙质发生，萌生或成骨的化合物。

    PROGENITOR CELL REPLICATION AND DIFFERENTIATION IN 3D
    6.
    发明申请
    PROGENITOR CELL REPLICATION AND DIFFERENTIATION IN 3D 审中-公开
    预处理细胞在3D中的复制和分化

    公开(公告)号：US20110020452A1

    公开(公告)日：2011-01-27

    申请号：US12438543

    申请日：2007-08-22

    申请人： Jeremy J. Mao

    发明人： Jeremy J. Mao

    IPC分类号： A61K9/00 ,  A61K35/12 ,  A61P43/00

    CPC分类号： A61K35/28 ,  A61K38/1841 ,  A61L27/3834 ,  C12N5/0655 ,  C12N5/0663 ,  C12N2501/15 ,  C12N2533/40 ,  C12N2533/72

    摘要： The present invention is directed to a new approach towards in situ differentiation of tissue progenitor cells, without the coventional requirements of weeks of cellular manipulation and treatment. Such approach circumvents the need for 2D culturing and differentiation of tissue progenitor cells before implanting in a 3D biocompatible matrix, thus providing convenience, cost savings, and time savings. One aspect of the invention provides an engineered tissue composition comprising substantially undifferentiated tissue progenitor cells in a biphasic matrix material, along with growth factors or encapsulated growth factors. Another aspect of the invention includes methods for making the compositions described herein. Another aspect of the invention includes methods of therapeutic treatment using the compositions described herein.

    摘要翻译： 本发明涉及一种用于组织祖细胞的原位分化的新方法，而不需要数周的细胞操纵和治疗的常规要求。 这种方法避免了在植入3D生物相容性矩阵之前对组织祖细胞的2D培养和分化的需要，从而提供方便，成本节省和时间节省。 本发明的一个方面提供了一种工程化组织组合物，其包含双相基质材料中的基本上未分化的组织祖细胞，以及生长因子或包封的生长因子。 本发明的另一方面包括制备本文所述组合物的方法。 本发明的另一方面包括使用本文所述的组合物进行治疗性治疗的方法。

    TREATMENT FOR BONE FORMATION DISORDERS BY GROWTH FACTOR DELIVERY
    9.
    发明申请
    TREATMENT FOR BONE FORMATION DISORDERS BY GROWTH FACTOR DELIVERY 审中-公开
    通过生长因子递送治疗骨形成疾病

    公开(公告)号：US20100034892A1

    公开(公告)日：2010-02-11

    申请号：US12439669

    申请日：2007-08-22

    申请人： Jeremy J. Mao

    发明人： Jeremy J. Mao

    IPC分类号： A61K9/16 ,  A61K35/12 ,  A61K38/16

    CPC分类号： A61K38/18 ,  A61K9/50 ,  A61K31/7088 ,  A61K35/00 ,  A61K35/33 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1866 ,  A61K38/1875 ,  A61K45/06

    摘要： It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (CTGF), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof.

    摘要翻译： 已经发现，某些生长因子可以通过促进成纤维细胞分化和/或成骨细胞分化的抑制来延缓诸如颅缝合的组织部位的骨化。 本文提供了通过将包含结缔组织生长因子（CTGF）和任选的其它生长因子或成纤维细胞或祖细胞的组合物施用于组织部位来治疗骨形成条件或病症例如解剖条件或异位矿化条件的方法 有需要的受试者。