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公开(公告)号：US09273298B2
公开(公告)日：2016-03-01
申请号：US13283564
申请日：2011-10-27
IPC分类号： C12N9/88 , C12N1/20 , C12N15/00 , C12N1/14 , C07H21/04 , C12N15/79 , C12N15/74 , C12N15/63 , C12P5/00
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved specific productivity. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in host cells.
摘要翻译： 本发明提供包含至少一种具有提高的比生产率的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于增加宿主细胞中异戊二烯生产的变体植物异戊二烯合成酶。
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2.发明授权公开(公告)号：US08518686B2
公开(公告)日：2013-08-27
申请号：US12765825
申请日：2010-04-22
申请人： Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
发明人： Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
CPC分类号： C12P5/007 , C07K2299/00 , C12N9/88 , C12Y402/03027
摘要： The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
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公开(公告)号：US20120014885A1
公开(公告)日：2012-01-19
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/64 , A61Q17/04 , A61Q5/00 , A61Q1/02 , A61Q19/10 , A61Q1/10 , A61K38/08 , A61K38/16 , A61Q7/02 , C07K19/00 , A61Q15/00 , A61Q1/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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4.发明申请THREE-DIMENSIONAL STRUCTURE OF ISOPRENE SYNTHASE AND ITS USE THEREOF FOR GENERATING VARIANTS 有权异丙肾上腺素的三维结构及其用于产生变异体公开(公告)号：US20110076743A1
公开(公告)日：2011-03-31
申请号：US12765825
申请日：2010-04-22
申请人： Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
发明人： Zachary Quinn Beck , Richard R. Bott , Christopher Lee Rife , Derek H. Wells , Jeffrey V. Miller
CPC分类号： C12P5/007 , C07K2299/00 , C12N9/88 , C12Y402/03027
摘要： The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
摘要翻译： 本发明提供了三叶虫异戊二烯合酶和异戊二烯异戊二烯合酶的三维结构。 本发明还提供使用三维结构设计异戊二烯合酶的方法，所述异戊二烯合酶具有改进的微生物宿主细胞中异戊二烯生产增加的活性。 本发明的生物合成生产的异戊二烯可用于制造橡胶和弹性体。
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公开(公告)号：US5414962A
公开(公告)日：1995-05-16
申请号：US282775
申请日：1994-07-29
申请人： John T. Forbis , David Klimek , Jeffrey V. Miller
发明人： John T. Forbis , David Klimek , Jeffrey V. Miller
CPC分类号： B29C65/3612 , B29C66/1142 , B29C66/5241 , B29C66/52431 , B29C66/55 , B29C66/72523 , E05D13/1207 , E06B3/44 , B29C66/52231 , B29C66/71 , B29C66/727 , B29K2023/12 , B29K2025/00 , B29K2027/06 , B29K2055/02 , B29K2069/00 , B29K2101/12 , B29K2105/04 , B29K2105/203 , B29L2031/005 , E05Y2900/148 , E06B2003/4446 , E06B2003/4453 , E06B2003/4461 , E06B2003/4469 , E06B2003/4476 , E06B3/4407
摘要： A window assembly has a sash vertically movable within a window jamb and positioned in the jamb by elongated side guide tubes enclosing counter balance means and resiliently biased partially into engagement with side ploughs of said sash, with the guide tubes extending outwardly from channels provided in opposed side jamb members. The guide tubes prevent lateral displacement of the sash as the sash is positioned within and moves from a window open to a window closed position within the plane of the jamb. The guide tubes can be reciprocally and resiliently compressed into the channels to release the ploughs and sash whereby the sash can be removed from the window construction.
摘要翻译： 窗户组件具有可在窗口边框内垂直移动的窗框，并且通过细长的侧导向管包围反平衡装置并且部分地弹性偏压地与所述窗扇的侧犁接合而定位在边框中，引导管从设置在相对的 侧边的成员。 引导管防止窗扇位于侧板的平面内并从窗口打开到窗户关闭位置的位置移动，从而阻止窗扇的横向位移。 引导管可以往复并弹性地压缩到通道中以释放犁和窗扇，从而窗框可以从窗构造中移除。
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公开(公告)号：US20130045891A1
公开(公告)日：2013-02-21
申请号：US13283564
申请日：2011-10-27
摘要： The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved specific productivity. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in host cells.
摘要翻译： 本发明提供包含至少一种具有提高的比生产率的异戊二烯合酶的方法和组合物。 特别地，本发明提供用于增加宿主细胞中异戊二烯生产的变体植物异戊二烯合成酶。
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公开(公告)号：US4757012A
公开(公告)日：1988-07-12
申请号：US620651
申请日：1984-06-14
申请人： David A. Estell , Robert A. Lazarus , David R. Light , Jeffrey V. Miller , William H. Rastetter
发明人： David A. Estell , Robert A. Lazarus , David R. Light , Jeffrey V. Miller , William H. Rastetter
CPC分类号： C12Y101/01274 , C12N9/0006 , C12P7/60
摘要： Recombinant plasmids containing the gene encoding 2,5-diketogluconic acid reductase are prepared and used to transform microorganisms. 2,5,DKG reductase is expressed by the microorganisms.
摘要翻译： 制备含有编码2,5-二酮葡萄糖酸还原酶基因的重组质粒，用于转化微生物。 2,5，DKG还原酶由微生物表达。
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公开(公告)号：US09084734B2
公开(公告)日：2015-07-21
申请号：US11919717
申请日：2006-04-25
申请人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
发明人： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita van Kimmenade , Gudrun Vogtentanz
IPC分类号： A61K8/02 , A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
CPC分类号： A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
摘要： The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. IN alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
摘要翻译： 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或毛发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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