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1.发明授权Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids 有权用于增强甲羟戊酸，异戊二烯和类异戊二烯生产的重组微生物公开(公告)号：US09121038B2
公开(公告)日：2015-09-01
申请号：US13459067
申请日：2012-04-27
申请人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
发明人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
IPC分类号： C12N1/20 , C12N1/00 , C12P5/02 , C07H21/04 , C12P5/00 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/18 , C12N9/88 , C12P7/02 , C12P7/04 , C12P7/42
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/0008 , C12N9/1025 , C12N9/1029 , C12N9/1217 , C12N9/18 , C12N9/88 , C12N15/70 , C12P5/002 , C12P5/026 , C12P7/02 , C12P7/04 , C12P7/42 , C12Y101/01027 , C12Y101/01034 , C12Y101/01037 , C12Y102/01051 , C12Y102/04001 , C12Y203/01008 , C12Y203/01016 , C12Y203/03001 , C12Y203/0301 , C12Y207/02001 , C12Y301/01031 , C12Y401/01031 , Y02E50/343
摘要： The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms by engineering a microorganism for increased carbon flux towards mevalonate production in the following enzymatic pathways: (a) citrate synthase, (b) phosphotransacetylase, (c) acetate kinase, (d) lactate dehydrogenase, (e) malic enzyme, and (f) pyruvate dehydrogenase such that one of more of the enzyme activity is modulated. In addition, production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids can be further enhanced by the heterologous expression of the mvaE and mvaS genes (such as, but not limited to, mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus).
摘要翻译： 本发明的特征在于通过在以下酶促途径中通过工程化微生物来增加碳通量以产生甲羟戊酸来生产甲羟戊酸，异戊二烯，类异戊二烯前体分子和/或类异戊二烯的组合物和方法：（a）柠檬酸合酶 ）磷酸转乙酰酶，（c）乙酸激酶，（d）乳酸脱氢酶，（e）苹果酸酶和（f）丙酮酸脱氢酶，使得其中一种酶活性被调节。 此外，通过mvaE和mvaS基因的异源表达（例如但不限于来自生物体李斯特氏菌DSM的mvaE和mvaS基因）可以进一步增强甲羟戊酸，异戊二烯，类异戊二烯前体分子和/或类异戊二烯的生产 20601，屎肠球菌，，肠球菌EG2，和黑麦草肠球菌）。
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公开(公告)号：US20120220008A1
公开(公告)日：2012-08-30
申请号：US12507530
申请日：2009-07-22
申请人： David H Sherman , Zachary Q. Beck , Yousong Ding
发明人： David H Sherman , Zachary Q. Beck , Yousong Ding
摘要： The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
摘要翻译： 本发明提供涉及cryptophycin生物合成的多肽和编码这些多肽的核酸分子。 本发明的核酸分子和多肽或其变体可用于本发明的方法中以产生隐球菌素。
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3.发明申请INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY 有权使用ARCHAEAL LOWER MEVALONATE PATHWAY增加的ISOPRENE生产公开(公告)号：US20100086978A1
公开(公告)日：2010-04-08
申请号：US12560390
申请日：2009-09-15
CPC分类号： C12P5/007 , C12N9/1205 , C12N9/88 , C12P9/00 , C12Y207/01036 , C12Y402/03027 , Y02P20/52
摘要： The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
摘要翻译： 本发明的特征在于使用反馈抗性甲羟戊酸激酶多肽（例如古细菌甲羟戊酸激酶多肽）从培养细胞产生异戊二烯的方法。 得到的异戊二烯组合物可以具有增加的异戊二烯的产率和/或纯度。
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4.发明授权公开(公告)号：US07229814B2
公开(公告)日：2007-06-12
申请号：US11122396
申请日：2005-05-05
CPC分类号： C12N9/0071 , C12N9/14 , C12N9/16 , C12N15/52 , C12P17/16
摘要： The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
摘要翻译： 本发明提供涉及cryptophycin生物合成的多肽和编码这些多肽的核酸分子。 本发明的核酸分子和多肽或其变体可用于本发明的方法中以产生隐球菌素。
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5.发明申请PRODUCTION OF ISOPRENE, ISOPRENOID PRECURSORS, AND ISOPRENOIDS USING ACETOACETYL-COA SYNTHASE 审中-公开使用乙酰乙酰辅酶A合成酶生产异丙苯，异丙肾上腺素和异吲哚公开(公告)号：US20130122562A1
公开(公告)日：2013-05-16
申请号：US13566916
申请日：2012-08-03
CPC分类号： C12N15/81 , C08F36/08 , C12N9/1029 , C12N9/1085 , C12N9/88 , C12N15/70 , C12P5/007 , C12Y203/01194 , C12Y402/03027 , Y02E50/343 , Y02P20/582
摘要： This invention relates to a recombinant microorganism capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, the acetoacetyl-CoA synthase gene encoding an enzyme capable of synthesizing acetoacetyl-CoA from malonyl-CoA and acetyl-CoA and one or more genes involved in isoprene biosynthesis that enables synthesis of isoprene from acetoacetyl-CoA are introduced into a host microorganism.
摘要翻译： 本发明涉及能够以高效率利用这种重组微生物产生异戊二烯和异戊二烯生产的重组微生物。 在本发明中，将编码能够从丙二酰辅酶A和乙酰辅酶A合成乙酰乙酰辅酶A的酶的乙酰乙酰辅酶A合成酶基因和能够从乙酰乙酰辅酶A合成异戊二烯生物合成的一个或多个基因导入宿主 微生物。
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6.发明授权公开(公告)号：US08313936B2
公开(公告)日：2012-11-20
申请号：US12507530
申请日：2009-07-22
申请人： David H Sherman , Zachary Q Beck , Yousong Ding
发明人： David H Sherman , Zachary Q Beck , Yousong Ding
摘要： The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
摘要翻译： 本发明提供涉及cryptophycin生物合成的多肽和编码这些多肽的核酸分子。 本发明的核酸分子和多肽或其变体可用于本发明的方法中以产生隐球菌素。
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7.发明授权公开(公告)号：US07566558B2
公开(公告)日：2009-07-28
申请号：US11830656
申请日：2007-07-30
申请人： David H. Sherman , Zachary Q. Beck , Yousong Ding
发明人： David H. Sherman , Zachary Q. Beck , Yousong Ding
摘要： The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.
摘要翻译： 本发明提供涉及cryptophycin生物合成的多肽和编码这些多肽的核酸分子。 本发明的核酸分子和多肽或其变体可用于本发明的方法中以产生隐球菌素。
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8.发明授权公开(公告)号：US08455236B2
公开(公告)日：2013-06-04
申请号：US12978324
申请日：2010-12-23
CPC分类号： C12N15/52 , C12N15/635 , C12N15/70 , C12P5/007 , C12P7/42
摘要： Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.
摘要翻译： 本文提供用于增加异戊二烯生产的改进的组合物和方法。 本文还提供了用于增加能够生物活性的异源多肽的生产的改进的组合物和方法。
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9.发明申请公开(公告)号：US20130089906A1
公开(公告)日：2013-04-11
申请号：US13646562
申请日：2012-10-05
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N1/12 , C12N1/14 , C12N1/20 , C12N9/1085 , C12N9/88 , C12N15/70 , C12P7/42 , C12Y203/01008 , C12Y205/01 , C12Y401/02009 , C12Y402/03027 , C12Y503/03002 , Y02P20/52
摘要： The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
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10.发明申请PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS USING GENES ENCODING POLYPEPTIDES HAVING THIOLASE, HMG-COA SYNTHASE AND HMG-COA REDUCTASE ENZYMATIC ACTIVITIES 有权使用编码具有THIOLASE，HMG-COA合成酶和HMG-COA还原酶活性的多肽的基因生产甲酸，异丙肾上腺素和异维A公开(公告)号：US20120276603A1
公开(公告)日：2012-11-01
申请号：US13459033
申请日：2012-04-27
申请人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
发明人： Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1025 , C12N9/1029 , C12N15/70 , C12N15/81 , C12P5/002 , C12P7/02 , C12P7/04 , C12P7/42 , C12Y101/01034 , C12Y203/01016 , C12Y203/0301 , Y02E50/343
摘要： The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
摘要翻译： 本发明的特征在于通过来自生物李斯特氏菌DSM 20601，屎肠球菌，，肠球菌EG2的mvaE和mvaS基因的异源表达增加微生物中甲羟戊酸，异戊二烯，类异戊二烯前体分子和/或类异戊二烯生产的组合物和方法， 和肠球菌（Enterococcus casseliflavus）。
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