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32 条记录 (耗时 0.02 秒)

    Process and apparatus for continuous wet granulation of powder material
    2.
    发明授权
    Process and apparatus for continuous wet granulation of powder material 有权
    粉末材料连续湿法造粒的工艺和装置

    公开(公告)号：US08231375B2

    公开(公告)日：2012-07-31

    申请号：US13009309

    申请日：2011-01-19

    申请人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    发明人： Jean-Paul Remon ,  Chris Vervaet ,  Eseldin Keleb ,  An Vermeire

    IPC分类号： B29B7/42 ,  B29B7/46 ,  B29B9/08

    CPC分类号： B01J2/20 ,  A23P10/25 ,  A61K9/1623 ,  A61K9/1694 ,  A61K9/20 ,  B01J2/10

    摘要： An apparatus for wet granulating a powder material comprises:—a barrel having a granulation chamber and being provided with a first inlet (1) for receiving said powder material and for supplying it to said granulation chamber and with a second inlet (2) for receiving a granulating liquid and for supplying it to said granulation chamber, said granulation having an aperture (9) for discharge of granules from said barrel, and—a transporting means (S) for advancing said powder material toward the end of said granulation chamber while granulating it with the aid of said granulating liquid, said transporting means (S) comprising a first transport zone (4) at its rear end, an agglomeration zone (5) downstream from the first transport zone (4) and a second transport zone (8) at its front end, said first inlet (1) and said second inlet (2) being positioned above the first transport zone (4), wherein said aperture (9) has a shape tightly fitting the terminal portion of the transporting means (S) for directly discharging said granules from the granulation chamber. The apparatus is useful for continuously wet granulating biologically-active ingredient formulations, chemicals, detergents and foodstuffs.

    摘要翻译： 用于湿粉碎粉末材料的设备包括： - 具有造粒室的桶，并且设置有用于接收所述粉末材料并将其供应到所述造粒室的第一入口（1）和用于接收的第二入口（2） 造粒液体并将其供给到所述造粒室，所述造粒物具有用于从所述筒排出颗粒的孔（9），和用于将所述粉末材料朝着造粒室的端部推进的输送装置（S） 所述输送装置（S）在其后端包括第一输送区（4），第一输送区（4）下游的附聚区（5）和第二输送区（8） ）在其前端，所述第一入口（1）和所述第二入口（2）位于所述第一输送区（4）的上方，其中所述孔（9）具有紧密地配合所述输送装置 （S），用于从造粒室直接排出所述颗粒。 该设备可用于连续湿法制粒生物活性成分配方，化学品，洗涤剂和食品。

    High release solid preparation, preparation and use thereof
    5.
    发明授权
    High release solid preparation, preparation and use thereof 失效
    高释放固体制剂，其制备和用途

    公开(公告)号：US06368634B1

    公开(公告)日：2002-04-09

    申请号：US08537793

    申请日：1996-02-27

    申请人： Jean Paul Remon

    发明人： Jean Paul Remon

    IPC分类号： A61K950

    CPC分类号： A61K9/1652 ,  A61K9/1617

    摘要： A solid preparation for a substantially immediate release of an active agent with low or very low solubility, which contains the active agent dissolved in a solubilizer, said dissolved active agent being contained in solid particles which are agglomerated into a system of agglomerated particles which is not a matrix or gelling forming agent.

    摘要翻译： 用于基本上立即释放具有低或非常低的溶解度的活性剂的固体制剂，其含有溶解在增溶剂中的活性剂，所述溶解的活性剂包含在固体颗粒中，所述固体颗粒凝聚成不是聚集颗粒的体系 基质或胶凝形成剂。

    INTRAVAGINAL DELIVERY SYSTEM
    6.
    发明申请
    INTRAVAGINAL DELIVERY SYSTEM 有权
    INTRAVAGINAL交付系统

    公开(公告)号：US20140154293A1

    公开(公告)日：2014-06-05

    申请号：US14131495

    申请日：2012-07-07

    申请人： Jean Paul Remon ,  Chris Vervaet ,  Hans Verstraelen ,  Marleen Temmerman

    发明人： Jean Paul Remon ,  Chris Vervaet ,  Hans Verstraelen ,  Marleen Temmerman

    IPC分类号： A61K47/32 ,  A61K47/38 ,  A61K31/19

    CPC分类号： A61K47/32 ,  A61K9/0036 ,  A61K31/19 ,  A61K47/38

    摘要： The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.

    摘要翻译： 本发明一般涉及阴道内递送系统及其用途及其制造和使用方法。 特别地，本发明涉及用于控制释放一种或多种有机酸如乳酸的阴道内递送系统; 所述阴道内递送系统的特征在于其包含乙烯乙酸乙烯酯（EVA）共聚物和羧酸聚合物的组合，例如甲基丙烯酸 - 甲基丙烯酸酯共聚物。

    Immediate release pharmaceutical granule compositions and a continuous process for making them
    8.
    发明授权
    Immediate release pharmaceutical granule compositions and a continuous process for making them 失效
    立即释放药物颗粒组合物和制备它们的连续方法

    公开(公告)号：US08349366B2

    公开(公告)日：2013-01-08

    申请号：US12815715

    申请日：2010-06-15

    申请人： Jean Paul Remon ,  Chris Vervaet

    发明人： Jean Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1694

    摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from above about 20% to 50% by weight of the composition, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 85% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharma-ceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.

    摘要翻译： 基本上由以下组成的混合物的药物或兽用颗粒组合物：（i）至少一种可分类为生物制药分类系统的II类或IV类的药物，其中所述药物（i）构成高于约20％至50 所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂代表所述组合物的40重量％至85重量％ 组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且占所述第二赋形剂的15重量％至40重量％ 所述组合物和任选的一种或多种选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂的药物可接受的填料，其中重量比 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例为1：1至5：1。

    Immediate release pharmaceutical granule compositions and a continuous process for making them
    9.
    发明授权
    Immediate release pharmaceutical granule compositions and a continuous process for making them 失效
    立即释放药物颗粒组合物和制备它们的连续方法

    公开(公告)号：US08337897B2

    公开(公告)日：2012-12-25

    申请号：US12815781

    申请日：2010-06-15

    申请人： Jean Paul Remon ,  Chris Vervaet

    发明人： Jean Paul Remon ,  Chris Vervaet

    IPC分类号： A61K9/14

    CPC分类号： A61K9/1652 ,  A61K9/1641 ,  A61K9/1694

    摘要： A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classification System, wherein said drug (i) constitutes from 0.5% to 20% by weight of the composition, and excipients, said pharmaceutical or veterinary granule composition providing a drug release of at least 70% within 10 minutes in water, (ii) a first excipient being a maltodextrin representing from 40% by weight to 80% by weight of said composition, (iii) a wetting amount of a second excipient being a polyethylene glycol having a weight number molecular weight between 300 and 5,000, said second excipient comprising a solid fraction and a liquid fraction, and representing from 15% to 40% by weight of said composition, and optionally one or more pharmaceutically acceptable fillers selected from the group consisting of hydrocolloids, glidants, lubricants, surfactants and diluents, wherein the weight ratio of said first excipient (ii) to said second excipient (iii) is in a range from 1:1 to 5:1.

    摘要翻译： 以混合物形式的药物或兽用颗粒组合物，其基本上由以下组成：（i）至少一种可分类为生物药物分类系统的II类或IV类的药物，其中所述药物（i）构成0.5％至20％ 所述组合物的重量和赋形剂，所述药物或兽用颗粒组合物在水中在10分钟内提供至少70％的药物释放，（ii）作为麦芽糖糊精的第一赋形剂，代表40重量％至80重量％ 所述组合物，（iii）第二赋形剂的润湿量，其为重量数分子量为300至5,000的聚乙二醇，所述第二赋形剂包含固体部分和液体部分，并且代表15重量％至40重量％ 的所述组合物，以及任选的一种或多种药学上可接受的填料，其选自水胶体，助流剂，润滑剂，表面活性剂和稀释剂，其中重量 所述第一赋形剂（ii）与所述第二赋形剂（iii）的比例在1:1至5:1的范围内。